It will be observed that the pulse is not mentioned in the above case, until its absence is alluded to, when the patient was already cold, and the breathing is not alluded to throughout the account; indeed, it is not known when the patient died. She was alive after the application of the nitric acid, as she was observed to move her legs, but further than this there is no clear evidence.
It is perhaps an open question whether this patient died at once from the direct effects of the chloroform, or whether she died after partially recovering and going on favourably for a time. The account would, at first view, seem to favour the latter opinion, but it is not corroborated by any other case. Patients have been partially recovered from the effects of an overdose, without being entirely restored, and others have sunk after great operations, attended with hæmorrhage, when the effects of the chloroform had more or less subsided, but there is no instance of a patient going on favourably, and partially recovering from the influence of the vapour, and then dying suddenly without any other known cause. Patients have occasionally become faint whilst recovering from chloroform, more especially if they remain in the sitting posture, but in those cases the right side of the heart is probably insufficiently supplied with blood; whilst, in the case under consideration, the patient was lying, and the right cavities of the heart were found full after death, the serum in the pericardium showing that they had probably been distended when death took place. If Mr. Heath had made any observation which enabled him to say that the patient was really alive, when he went up to the foot of the bed, before leaving the ward, it would decide the question, and show that death did not take place at once from the direct effects of the chloroform, but he only makes the negative remark that he did not notice anything unusual about the patient.
I had an opportunity of examining the particular inhaler employed, and found that it was so arranged that the vapour might be breathed from it in much greater proportion than would be safe, if precautions were not taken to leave the expiratory valve a considerable way open, especially when the high temperature of the weather at the time is taken into account.
The foregoing cases comprise all the instances I have seen recorded in which death appears to have been occasioned by the administration of chloroform, and not by other causes in operation about the same time. A few additional cases have indeed been referred to by different authors where death was probably caused by chloroform, but as I do not find that the details have been published, I cannot make them available in an inquiry respecting the cause and prevention of these accidents.
In June 1852, Dr. Simpson alluded in the following terms to an accident from chloroform which had occurred near Glasgow:—“In this instance, chloroform was given by the practitioner for tooth extraction; but, I am sorry to add, none of the parties present were at the time in a condition to give any satisfactory evidence.”[[125]]
A person, named Breton, a dealer in porcelain, died in Paris, in the early part of 1853, immediately after a few inspirations of chloroform, which was administered with the intention of removing a tumour of the cheek. An action was brought against Dr. Triquet and M. Masson for causing death by imprudence in this case; and at the trial which ensued, various interesting opinions were given, and the accused practitioners were ultimately exonerated.[[126]] I have not, however, met with any record of the symptoms which occurred in the case.
In relating the case of death from chloroform, which occurred in his practice, to the Medical and Chirurgical Society of Edinburgh, Dr. Roberts referred to another death from chloroform in tooth-drawing which took place in the neighbourhood from which his own patient came, just previously to October 1855; but I have not met with any account of the case so alluded to. Dr. Mackenzie of Kelso also alluded in the same Society, in the following year, to a death from chloroform which had occurred at Coldstream, and I do not know whether this was the case to which Dr. Roberts had alluded, or a fresh one.
One of the surgeons to the hospital at St. Louis, who was lately visiting the medical institutions of London, informed me that there had been three deaths from chloroform at his hospital out of between six and seven hundred operations in which it had been administered. I did not learn the particulars of those fatal cases.
There have been several cases in which persons have been found dead after inhaling chloroform when no one else was present, either for toothache or some other affection, but I have not included such cases in the above list, as they throw no light on the way in which death is occasioned. The simple way to avoid such accidents as those just alluded to, is for persons to abstain from inhaling chloroform, when no one is by to watch its effects.