[§ 7.] That the last of these three modes of investigation is applicable to the case, no one has ever seriously contended. No conclusions of value on a subject of such intricacy, ever were obtained in that way. The utmost that could result would be a vague general impression for or against the efficacy of mercury, of no avail for guidance unless confirmed by one of the other two methods. Not that the results, which this method strives to obtain, would not be of the utmost possible value if they could be obtained. If all the cases of recovery which presented themselves, in an examination extending to a great number of instances, were cases in which mercury had been administered, we might generalize with confidence from this experience, and should have obtained a conclusion of real value. But no such basis for generalization can we, in a case of this description, hope to obtain. The reason is that which we have spoken of as constituting the characteristic imperfection of the Method of Agreement; Plurality of Causes. Supposing even that mercury does tend to cure the disease, so many other causes, both natural and artificial, also tend to cure it, that there are sure to be abundant instances of recovery in which mercury has not been administered: unless, indeed, the practice be to administer it in all cases; on which supposition it will equally be found in the cases of failure.
When an effect results from the union of many causes, the share which each has in the determination of the effect cannot in general be great: and the effect is not likely, even in its presence or absence, still less in its variations, to follow, even approximately, any one of the causes. Recovery from a disease is an event to which, in every case, many influences must concur. Mercury may be one such influence; but from the very fact that there are many other such, it will necessarily happen that although mercury is administered, the patient, for want of other concurring influences, will often not recover, and that he often will recover when it is not administered, the other favourable influences being sufficiently powerful without it. Neither, therefore, will the instances of recovery agree in the administration of mercury, nor will the instances of failure agree in its non-administration. It is much if, by multiplied and accurate returns from hospitals and the like, we can collect that there are rather more recoveries and rather fewer failures when mercury is administered than when it is not; a result of very secondary value even as a guide to practice, and almost worthless as a contribution to the theory of the subject.
[§ 8.] The inapplicability of the method of simple observation to ascertain the conditions of effects dependent on many concurring causes, being thus recognised; we shall next inquire whether any greater benefit can be expected from the other branch of the à posteriori method, that which proceeds by directly trying different combinations of causes, either artificially produced or found in nature, and taking notice what is their effect: as, for example, by actually trying the effect of mercury, in as many different circumstances as possible. This method differs from the one which we have just examined, in turning our attention directly to the causes or agents, instead of turning it to the effect, recovery from the disease. And since, as a general rule, the effects of causes are far more accessible to our study than the causes of effects, it is natural to think that this method has a much better chance of proving successful than the former.
The method now under consideration is called the Empirical Method; and in order to estimate it fairly, we must suppose it to be completely, not incompletely, empirical. We must exclude from it everything which partakes of the nature not of an experimental but of a deductive operation. If for instance we try experiments with mercury upon a person in health, in order to ascertain the general laws of its action upon the human body, and then reason from these laws to determine how it will act upon persons affected with a particular disease, this may be a really effectual method, but this is deduction. The experimental method does not derive the law of a complex case from the simpler laws which conspire to produce it, but makes its experiments directly upon the complex case. We must make entire abstraction of all knowledge of the simpler tendencies, the modi operandi of mercury in detail. Our experimentation must aim at obtaining a direct answer to the specific question, Does or does not mercury tend to cure the particular disease?
Let us see, therefore, how far the case admits of the observance of those rules of experimentation, which it is found necessary to observe in other cases. When we devise an experiment to ascertain the effect of a given agent, there are certain precautions which we never, if we can help it, omit. In the first place, we introduce the agent into the midst of a set of circumstances which we have exactly ascertained. It needs hardly be remarked how far this condition is from being realized in any case connected with the phenomena of life; how far we are from knowing what are all the circumstances which pre-exist in any instance in which mercury is administered to a living being. This difficulty, however, though insuperable in most cases, may not be so in all; there are sometimes concurrences of many causes, in which we yet know accurately what the causes are. Moreover, the difficulty may be attenuated by sufficient multiplication of experiments, in circumstances rendering it improbable that any of the unknown causes should exist in them all. But when we have got clear of this obstacle, we encounter another still more serious. In other cases, when we intend to try an experiment, we do not reckon it enough that there be no circumstance in the case the presence of which is unknown to us. We require also that none of the circumstances which we do know, shall have effects susceptible of being confounded with those of the agent whose properties we wish to study. We take the utmost pains to exclude all causes capable of composition with the given cause; or if forced to let in any such causes, we take care to make them such that we can compute and allow for their influence, so that the effect of the given cause may, after the subduction of those other effects, be apparent as a residual phenomenon.
These precautions are inapplicable to such cases as we are now considering. The mercury of our experiment being tried with an unknown multitude (or even let it be a known multitude) of other influencing circumstances, the mere fact of their being influencing circumstances implies that they disguise the effect of the mercury, and preclude us from knowing whether it has any effect or not. Unless we already knew what and how much is owing to every other circumstance, (that is, unless we suppose the very problem solved which we are considering the means of solving,) we cannot tell that those other circumstances may not have produced the whole of the effect, independently or even in spite of the mercury. The Method of Difference, in the ordinary mode of its use, namely by comparing the state of things following the experiment with the state which preceded it, is thus, in the case of intermixture of effects, entirely unavailing; because other causes than that whose effect we are seeking to determine, have been operating during the transition. As for the other mode of employing the Method of Difference, namely by comparing, not the same case at two different periods, but different cases, this in the present instance is quite chimerical. In phenomena so complicated it is questionable if two cases, similar in all respects but one, ever occurred; and were they to occur, we could not possibly know that they were so exactly similar.
Anything like a scientific use of the method of experiment, in these complicated cases, is therefore out of the question. We can in the most favourable cases only discover, by a succession of trials, that a certain cause is very often followed by a certain effect. For, in one of these conjunct effects, the portion which is determined by any one of the influencing agents, is generally, as we before remarked, but small; and it must be a more potent cause than most, if even the tendency which it really exerts is not thwarted by other tendencies in nearly as many cases as it is fulfilled.
If so little can be done by the experimental method to determine the conditions of an effect of many combined causes, in the case of medical science; still less is this method applicable to a class of phenomena more complicated than even those of physiology, the phenomena of politics and history. There, Plurality of Causes exists in almost boundless excess, and effects are, for the most part, inextricably interwoven with one another. To add to the embarrassment, most of the inquiries in political science relate to the production of effects of a most comprehensive description, such as the public wealth, public security, public morality, and the like: results liable to be affected directly or indirectly either in plus or in minus by nearly every fact which exists, or event which occurs, in human society. The vulgar notion, that the safe methods on political subjects are those of Baconian induction—that the true guide is not general reasoning, but specific experience—will one day be quoted as among the most unequivocal marks of a low state of the speculative faculties in any age in which it is accredited. Nothing can be more ludicrous than the sort of parodies on experimental reasoning which one is accustomed to meet with, not in popular discussion only, but in grave treatises, when the affairs of nations are the theme. "How," it is asked, "can an institution be bad, when the country has prospered under it?" "How can such or such causes have contributed to the prosperity of one country, when another has prospered without them?" Whoever makes use of an argument of this kind, not intending to deceive, should be sent back to learn the elements of some one of the more easy physical sciences. Such reasoners ignore the fact of Plurality of Causes in the very case which affords the most signal example of it. So little could be concluded, in such a case, from any possible collation of individual instances, that even the impossibility, in social phenomena, of making artificial experiments, a circumstance otherwise so prejudicial to directly inductive inquiry, hardly affords, in this case, additional reason of regret. For even if we could try experiments upon a nation or upon the human race, with as little scruple as M. Magendie tried them on dogs and rabbits, we should never succeed in making two instances identical in every respect except the presence or absence of some one definite circumstance. The nearest approach to an experiment in the philosophical sense, which takes place in politics, is the introduction of a new operative element into national affairs by some special and assignable measure of government, such as the enactment or repeal of a particular law. But where there are so many influences at work, it requires some time for the influence of any new cause upon national phenomena to become apparent; and as the causes operating in so extensive a sphere are not only infinitely numerous, but in a state of perpetual alteration, it is always certain that before the effect of the new cause becomes conspicuous enough to be a subject of induction, so many of the other influencing circumstances will have changed as to vitiate the experiment.
Two, therefore, of the three possible methods for the study of phenomena resulting from the composition of many causes, being, from the very nature of the case, inefficient and illusory, there remains only the third,—that which considers the causes separately, and infers the effect from the balance of the different tendencies which produce it: in short, the deductive, or à priori method. The more particular consideration of this intellectual process requires a chapter to itself.