In 1507 Louis made war on Venice; and in the following year the famous Treaty of Cambrai was signed by Georges d'Amboise and Margaret of Austria. It was an agreement for a partition of the Venetian territories,—one of the most shameless public deeds in history. The Pope, the King of Aragon, Maximilian, Louis XII., were each to have a share. The war was pushed on with great vigour: the battle of Agnadello (14th May, 1509) cleared the King's way towards Venice; Louis was received with open arms by the North Italian towns, and pushed forward to within eight of Venice. The other Princes came up on every side; the proud "Queen of the Adriatic" was compelled to shrink within her walls, and wait till time dissolved the league. This was not long. The Pope, Julius II., had no wish to hand Northern Italy over to France; he had joined in the shameless league of Cambrai because he wanted to wrest the Romagna cities from Venice, and because he hoped to entirely destroy the ancient friendship between Venice and France. Successful in both aims, he now withdrew from the league, made peace with the Venetians, and stood forward as the head of a new Italian combination, with the Swiss for his fighting men. The strife was close and hot between Pope and King; Louis XII. lost his chief adviser and friend, Georges d'Amboise, the splendid churchman of the age, the French Wolsey; he thought no weapon better than the dangerous one of a council, with claims opposed to those of the papacy; first a National Council at Tours, then an attempted General Council at Pisa, were called on to resist the papal claims. In reply Julius II. created the Holy League of 1511, with Ferdinand of Aragon, Henry VIII. of England, and the Venetians as its chief members, against the French. Louis XII. showed vigour; he sent his nephew Gaston de Foix to subdue the Romagna and threaten the Venetian territories. At the battle of Ravenna, in 1512, Gaston won a brilliant victory and lost his life. From that moment disaster dogged the footsteps of the French in Italy, and before winter they had been driven completely out of the peninsula; the succession of the Medicean Pope, Leo X., to Julius II., seemed to promise the continuance of a policy hostile to France in Italy. Another attempt on Northern Italy proved but another failure, although now Louis XII., taught by his mishaps, had secured the alliance of Venice; the disastrous defeat of La Tremoille, near Novara (1513), compelled the French once more to withdraw beyond the Alps. In this same year an army under the Duc de Longueville, endeavouring to relieve Therouenne, besieged by the English and Maximilian, the Emperor-elect, was caught and crushed at Guinegate. A diversion in favour of Louis XII., made by James IV. of Scotland, failed completely; the Scottish King was defeated and slain at Flodden Field. While his northern frontier was thus exposed, Louis found equal danger threatening him on the east; on this aide, however, he managed to buy off the Swiss, who had attacked the duchy of Burgundy. He was also reconciled with the papacy and the House of Austria. Early in 1514 the death of Anne of Brittany, his spouse, a lady of high ambitions, strong artistic tastes, and humane feelings towards her Bretons, but a bad Queen for France, cleared the way for changes. Claude, the King's eldest daughter, was now definitely married to Francois d'Angouleme, and invested with the duchy of Brittany; and the King himself, still hoping for a male heir to succeed him, married again, wedding Mary Tudor, the lovely young sister of Henry VIII. This marriage was probably the chief cause of his death, which followed on New Year's day, 1515. His was, in foreign policy, an inglorious and disastrous reign; at home, a time of comfort and material prosperity. Agriculture flourished, the arts of Italy came in, though (save in architecture) France could claim little artistic glory of her own; the organisation of justice and administration was carried out; in letters and learning France still lagged behind her neighbours.

The heir to the crown was Francois d'Angouleme, great-grandson of that Louis d'Orleans who had been assassinated in the bad days of the strife between Burgundians and Armagnacs, in 1407, and great-great-grandson of Charles V. of France. He was still very young, very eager to be king, very full of far-reaching schemes. Few things in history are more striking than the sudden change, at this moment, from the rule of middle-aged men or (as men of fifty were then often called) old men, to the rule of youths,—from sagacious, worldly-prudent monarchs—to impulsive boys,—from Henry VII. to Henry VIII., from Louis XII. to Frangois I, from Ferdinand to Charles.

On the whole, Frangois I. was the least worthy of the three. He was brilliant, "the king of culture," apt scholar in Renaissance art and immorality; brave, also, and chivalrous, so long as the chivalry involved no self-denial, for he was also thoroughly selfish, and his personal aims and ideas were mean. His reign was to be a reaction from that of Louis XII.

From the beginning, Francois chose his chief officers unwisely. In Antoine du Prat, his new chancellor, he had a violent and lawless adviser; in Charles de Bourbon, his new constable, an untrustworthy commander. Forthwith he plunged into Italian politics, being determined to make good his claim both to Naples and to Milan; he made most friendly arrangements with the Archduke Charles, his future rival, promising to help him in securing, when the time came, the vast inheritances of his two grandfathers, Maximilian, the Emperor-elect, and Ferdinand of Aragon; never was a less wise agreement entered upon. This done, the Italian war began; Francois descended into Italy, and won the brilliant battle of Marignano, in which the French chivalry crushed the Swiss burghers and peasant mercenaries. The French then overran the north of Italy, and, in conjunction with the Venetians, carried all before them. But the triumphs of the sword were speedily wrested from him by the adroitness of the politician; in an interview with Leo X. at Bologna, Francois bartered the liberties of the Gallican Church for shadowy advantages in Italy. The 'Pragmatic Sanction of Bourgea', which now for nearly a century had secured to the Church of France independence in the choice of her chief officers, was replaced by a concordat, whereby the King allowed the papacy once more to drain the wealth of the Church of France, while the Pope allowed the King almost autocratic power over it. He was to appoint to all benefices, with exception of a few privileged offices; the Pope was no longer to be threatened with general councils, while he should receive again the annates of the Church.

The years which followed this brilliantly disastrous opening brought little good to France. In 1516 the death of Ferdinand the Catholic placed Charles on the throne of Spain; in 1519 the death of Maximilian threw open to the young Princes the most dazzling prize of human ambition,—the headship of the Holy Roman Empire. Francois I., Charles, and Henry VIII. were all candidates for the votes of the seven electors, though the last never seriously entered the lists. The struggle lay between Francois, the brilliant young Prince, who seemed to represent the new opinions in literature and art, and Charles of Austria and Spain, who was as yet unknown and despised, and, from his education under the virtuous and scholastic Adrian of Utrecht, was thought likely to represent the older and reactionary opinions of the clergy. After a long and sharp competition, the great prize fell to Charles, henceforth known to history as that great monarch and emperor, Charles V.

The rivalry between the Princes could not cease there. Charles, as representative of the House of Burgundy, claimed all that had been lost when Charles the Bold fell; and in 1521 the war broke out between him and Francois, the first of a series of struggles between the two rivals. While the King wasted the resources of his country on these wars, his proud and unwise mother, Louise of Savoy, guided by Antoine du Prat, ruled, to the sorrow of all, at home. The war brought no glory with it: on the Flemish frontier a place or two was taken; in Biscay Fontarabia fell before the arms of France; in Italy Francois had to meet a new league of Pope and Emperor, and his troops were swept completely out of the Milanese. In the midst of all came the defection of that great prince, the Constable de Bourbon, head of the younger branch of the Bourbon House, the most powerful feudal lord in France. Louise of Savoy had enraged and offended him, or he her; the King slighted him, and in 1523 the Constable made a secret treaty with Charles V. and Henry VIII., and, taking flight into Italy, joined the Spaniards under Lannoy. The French, who had again invaded the Milanese, were again driven out in 1524; on the other hand, the incursions of the imperialists into Picardy, Provence, and the southeast were all complete failures. Encouraged by the repulse of Bourbon from Marseilles, Francois I. once more crossed the Alps, and overran a great part of the valley of the Po; at the siege of Pavia he was attacked by Pescara and Bourbon, utterly defeated and taken prisoner (24th February, 1525); the broken remnants of the French were swept out of Italy at once, and Francois I. was carried into Spain, a captive at Madrid. His mother, best in adversity, behaved with high pride and spirit; she overawed disaffection, made preparations for resistance, looked out for friends on every side. Had Francois been in truth a hero, he might, even as a prisoner, have held his own; but he was unable to bear the monotony of confinement, and longed for the pleasures of France. On this mean nature Charles V. easily worked, and made the captive monarch sign the Treaty of Madrid (January 14, 1526), a compact which Francois meant to break as soon as he could, for he knew neither heroism nor good faith. The treaty stipulated that Francois should give up the duchy of Burgundy to Charles, and marry Eleanor of Portugal, Charles's sister; that Francois should also abandon his claims on Flanders, Milan, and Naples, and should place two sons in the Emperor's hands as hostages. Following the precedent of Louis XI. in the case of Normandy, he summoned an assembly of nobles and the Parliament of Paris to Cognac, where they declared the cession of Burgundy to be impossible. He refused to return to Spain, and made alliances wherever he could, with the Pope, with Venice, Milan, and England. The next year saw the ruin of this league in the discomfiture of Clement VII., and the sack of Rome by the German mercenaries under Bourbon, who was killed in the assault. The war went on till 1529, when Francois, having lost two armies in it, and gained nothing but loss and harm, was willing for peace; Charles V., alarmed at the progress of the Turks, was not less willing; and in August, 1529, the famous Treaty, of Cambrai, "the Ladies' Peace," was agreed to by Margaret of Austria and Louise of Savoy. Though Charles V. gave up all claim on the duchy of Burgundy, he had secured to himself Flanders and Artois, and had entirely cleared French influences out of Italy, which now became firmly fixed under the imperial hand, as a connecting link between his Spanish and German possessions. Francois lost ground and credit by these successive treaties, conceived in bad faith, and not honestly carried out.

No sooner had the Treaty of Cambrai been effectual in bringing his sons back to France, than Francois began to look out for new pretexts and means for war. Affairs were not unpromising. His mother's death in 1531 left him in possession of a huge fortune, which she had wrung from defenceless France; the powers which were jealous of Austria, the Turk, the English King, the members of the Smalkald league, all looked to Francois as their leader; Clement VII., though his misfortunes had thrown him into the Emperor's hands, was not unwilling to treat with France; and in 1533 by the compact of Marseilles the Pope broke up the friendship between Francois and Henry VIII., while he married his niece Catherine de' Medici to Henri, the second son of Francois. This compact was a real disaster to France; the promised dowry of Catherine—certain Italian cities—was never paid, and the death of Clement VII. in 1534 made the political alliance with the papacy a failure. The influence of Catherine affected and corrupted French history for half a century. Preparations for war went on; Francois made a new scheme for a national army, though in practice he preferred the tyrant's arm, the foreign mercenary. From his day till the Revolution the French army was largely composed of bodies of men tempted out of other countries, chiefly from Switzerland or Germany.

While the Emperor strove to appease the Protestant Princes of Germany by the Peace of Kadan (1534), Francois strengthened himself with a definite alliance with Soliman; and when, on the death of Francesco Sforza, Duke of Milan, who left no heirs, Charles seized the duchy as its overlord, Francois, after some bootless negotiation, declared war on his great rival (1536). His usual fortunes prevailed so long as he was the attacking party: his forces were soon swept out of Piedmont, and the Emperor carried the war over the frontier into Provence. That also failed, and Charles was fain to withdraw after great losses into Italy. The defence of Provence—a defence which took the form of a ruthless destruction of all its resources—had been entrusted to Anne de Montmorency, who henceforward became Constable of France, and exerted great influence over Francois I. Though these two campaigns, the French in Italy and the imperialist in Provence, had equally failed in 1536, peace did not follow till 1538, when, after the terrible defeat of Ferdinand of Austria by the Turks, Charles was anxious to have free hand in Germany. Under the mediation of Paul III. the agreement of Nice was come to, which included a ten years' truce and the abandonment by Francois of all his foreign allies and aims. He seemed a while to have fallen completely under the influence of the sagacious Emperor. He gave way entirely to the Church party of the time, a party headed by gloomy Henri, now Dauphin, who never lost the impress of his Spanish captivity, and by the Constable Anne de Montmorency; for a time the artistic or Renaissance party, represented by Anne, Duchesse d'Etampes, and Catherine de' Medici, fell into disfavour. The Emperor even ventured to pass through France, on his way from Spain to the Netherlands. All this friendship, however, fell to dust, when it was found that Charles refused to invest the Duc d'Orleans, the second son of Francois, with the duchy of Milan, and when the Emperor's second expedition against the sea-power of the Turks had proved a complete failure, and Charles had returned to Spain with loss of all his fleet and army. Then Francois hesitated no longer, and declared war against him (1541). The shock the Emperor had suffered inspirited all his foes; the Sultan and the Protestant German Princes were all eager for war; the influence of Anne de Montmorency had to give way before that of the House of Guise, that frontier family, half French, half German, which was destined to play a large part in the troubled history of the coming half-century. Claude, Duc de Guise, a veteran of the earliest days of Francois, was vehemently opposed to Charles and the Austro-Spanish power, and ruled in the King's councils. This last war was as mischievous as its predecessors no great battles were fought; in the frontier affairs the combatants were about equally fortunate; the battle of Cerisolles, won by the French under Enghien (1544), was the only considerable success they had, and even that was almost barren of results, for the danger to Northern France was imminent; there a combined invasion had been planned and partly executed by Charles and Henry VIII., and the country, almost undefended, was at their mercy. The two monarchs, however, distrusted one another; and Charles V., anxious about Germany, sent to Francois proposals for peace from Crespy Couvrant, near Laon, where he had halted his army; Francois, almost in despair, gladly made terms with him. The King gave up his claims on Flanders and Artois, the Emperor his on the duchy of Burgundy; the King abandoned his old Neapolitan ambition, and Charles promised one of the Princesses of the House of Austria, with Milan as her dower, to the Duc d'Orleans, second son of Francois. The Duke dying next year, this portion of the agreement was not carried out. The Peace of Crespy, which ended the wars between the two great rivals, was signed in autumn, 1544, and, like the wars which led to it, was indecisive and lame.

Charles learnt that with all his great power he could not strike a fatal blow at France; France ought to have learnt that she was very weak for foreign conquest, and that her true business was to consolidate and develop her power at home. Henry VIII. deemed himself wronged by this independent action on the part of Charles, who also had his grievances with the English monarch; he stood out till 1546, and then made peace with Francois, with the aim of forming a fresh combination against Charles. In the midst of new projects and much activity, the marrer of man's plots came on the scene, and carried off in the same year, 1547, the English King and Francois I., leaving Charles V. undisputed arbiter of the affairs of Europe. In this same year he also crushed the Protestant Princes at the battle of Muhlberg.

In the reign of Francois I. the Court looked not unkindly on the
Reformers, more particularly in the earlier years.