(2) The amount of destruction of tissue nucleo-proteins.
(3) The amount of purin bases formed in the muscle tissue.
(4) The amount of conversion of purin bases into the uric acid.
(5) The amount of destruction of uric acid, if any, occurring in the body.
(6) Possibly upon the capacity of the tissues to synthesize uric acid; and in case such power to synthesize uric acid exists upon the presence of the precursors of uric acid in the body.
(7) The retention of uric acid in the blood and tissues.
(8) The power of the kidney to excrete uric acid.
(9) The solubility of uric acid in urine—dependent upon the amount of neutral phosphates present, the temperature, reaction and concentration thereof.
Effect of Atophan on Exogenous Purins. (McLester, in “Archives of Internal Medicine.”)