Gout, with a section on ocular disease in the gouty - Llewellyn J. Llewellyn

Carbon dioxide	6·9
Nitrogen	11·6

It had become somewhat aerated on drawing, but allowance has been made for that.

	Milligrams per million litres.
Radium in the water of the King’s Well	0·1387
Niton (radium emanation) in the water of King’s Well	1·73
” ” ” ” of Cross Bath	1·19
” ” ” ” of Hetling Bath	1·70
” ” ” in the gas from King’s Well	33·65

[65] Bickel in a series of experiments in which the acid contents as well as the total amount of gastric juice were considered obtained the following results: simple gaseous waters (Apollinaris, Giesshübl), muriated waters (Rakoczy spring of Kissingen, Wiesbaden, Kochbrunnen), and muriated alkaline waters (Ems, Selters), all of them, as compared to distilled water and ordinary tap water, rather increased than decreased the specific secretory activity of the gastric mucous membrane, whereas simple alkaline waters (Vichy) and sulphated alkaline waters (Karlsbad) had a slight tendency to diminish, and the sulphated “bitter” waters (Hunyadi Janos water) decidedly diminished, the gastric secretory activity, although “bitter” waters sometimes induced a watery flow from the gastric mucosa, which increased the fluid contents of the stomach.

[66] Bain, of Harrogate, from his observations on a man with permanent cutaneous biliary fistula, found that the old sulphur spring of Harrogate increased both the quantity of bile and the bile solids. This, he thinks, may “fairly be taken as an index of the degree to which it stimulates the liver, and is, in fact, the most reliable indication of the value of a cholagogue.”

INDEX

A-amino-acids, [61]
Aborigines, gout unknown among, [2]
Abscess formation in peri-tophal tissues, [234]
skin resembling, in acute gout, [212]
“Accessory food factors” in diet of gouty, [339]
Adenase, [100], [101]
Adenine, [73], [75], [77], [98]
Aetius’s views on gout, [6]
Age factor in gout, [40]
influence of, on diet, in acute stage of gout, [333]
Agotan in treatment of acute gout, [379]
Aix massage baths, [427]
Alanine, uric acid excretion augmented by, [89]
Albuminuria, diet in, [358]
Alcohol and gout, [48]
hypersensitiveness of gouty to, [365]
in febrile stage of sthenic gout, [333]
in gout, [361]
in subjects of gouty glycosuria, [237]
modus operandi of, in induction of gout, [49]
plus overeating, cause of gout, [49]
Alcoholism, chronic, purin metabolism in, [115]
Alexander of Tralles’s views on gout, [5]
Alimentary canal, condition of, and gout, [174]
disorders, effects of radio-active waters on, [439]
tract, functional derangements of, in diagnosis of articular gout, [249]
X-ray examination of, in treatment of gout, [336]
Alkalies in inter-paroxysmal periods of gout, [392]
in treatment of acute gout, [383]
in treatment of chronic gout, [399]
Alkaline waters, simple, spas for, [441]
Alkapton in urine, [59]
Alkaptonuria, [69]
Allantoin, [104]
Alternatives in treatment of chronic gout, [401]
Alveolus, senile atrophy of, [329]
Amberg and Jones’ scheme of formation of uric acid, [104]
America, United States of, gout in, [47]
Amino-acetic-acid, [64]
Amino-acids and dicarboxylic amino-acids, [89]
deaminisation of, [62], [63]
fate of, [62]
in portal blood, [62]
in relation to gout, [64]
Amino-purins, as source of uric acid, [84]
Amylaceous dyspepsia, diet in, [351], [352]
Anacritical stage of depression, [211]
Anæmia in cases of long-standing gout, treatment of, [406]
retention capacity of tissues for uric acid in, [158]
Anatomical alterations in articulations, [54]
Anglo-Saxon period, prevalence of gout in, [2]
Animal cells, nucleic acid derived from, [98]
Animals, various, uric acid blood content of, [135]
Ankylosis in chronic gout, [287]
Anodyne preparations in treatment of acute gout, [384], [385]
Anodynes in acute gout, [383]
Antiquity of gout, [1]
Anuria, hysteria in, [126]
Aponeuroses, gouty polyarthritis in, [214]
Appendicitis, septic foci of, [184]
Appendix-dyspepsia, [184]
Arab physicians’ views on gout, [6]
Aretæus the Cappadocian’s views on gout, [4], [5]
Arterio-sclerosis, associated with gout, [245]
blood-content in, [127]
spa treatment of, [451]
Arthralgia, fleeting, [193]
Arthritic attacks, tophi formation preceding, [164]
iritis, [315]
Arthritides, specific infective, and gout, analogies between, [194]
Arthritis deformans, cleavage into two types, [18]
differentiation of, from chronic gout, [16]
rheumatoid, and osteoarthritis, [20]
Arthritis, gonococcal, acute, differential diagnosis from acute gouty polyarthritis, [270]
from gout, [259]
of tarsus and metatarsus, differential diagnosis from gout, [263]
gouty, [39]
definition of, [20]
frequency of tophi in, [255]
relation to local foci of infection, [185]
Greek designation, [3]
hæmophilia, differential diagnosis from chronic gout, [285]
infective, of undifferentiated type, differential diagnosis from acute polyarticular gout, [272]
skiagraphy in differential diagnosis of, [290]
non-gouty, hyper-uricæmia in, [140]
rheumatoid, [17]
differential diagnosis from chronic gout, [284]
local character of joint swellings, [284]
or atrophic, acute, differential diagnosis from acute gouty polyarthritis, [272]
skiagraphy in differential diagnosis of, [291]
syphilitic, differential diagnosis from chronic articular gout, [277]
secondary, differential diagnosis from acute gouty polyarthritis, [271]
tophi in relation to, [254]
Arthropathies, nerve, differential diagnosis from chronic gout, [284]
Articular gout, chronic, medicinal and other modes of therapy, [397]
etiological diagnosis, [247]
Articular lesions in chronic gout, distribution of, [226]
Asphyxias, local, of hands, in gout, [45]
Atophan, effect of, on exogenous purins, [110]
on uric acid excretion, [119]
indicated when gout attack imminent, [395]
in treatment of acute gout, [379]
in treatment of chronic gout, [403]
Auricular tophi, [202]
Auto-intoxication theory of gout, [182]
Auto-toxæmia theory of gout, [182]
Avicenna’s views on gout, [6]
Bacillus coli communis as causative agent in gout, [175]
Bacterial flora, intestinal, modifications in, [182]
Bacteriological examination in diagnosis of articular gout, [251]
Baillon’s dissociation of rheumatism from gout, [15]
Banting method in reduction of obesity, [357]
Barclay’s theories of ætiology of gout, [23]
Bath as residence for gouty, [419]
Bath waters, Sir W. Ramsay’s analysis of, [435]
Baths in treatment of gout, method of application, [427]
Beaumont, W. M., ocular disease in the gouty, [308]
Beauvais’s work on gout, [17]
Beer as beverage in gout, [362]
Benzoates in treatment of chronic gout, [401]
Berkart’s theory of ætiology of gout, [27]
views on gout, [56]
Beverages in gout, [359]
Bismuth carbonate in inter-paroxysmal periods of gout, [392]
Biurate of soda in gouty tophi, [151]
Blisters in treatment of acute gout, [386]
Blood, changes in, in acute gout, [210]
in chronic articular gout, [226]
in gouty polyarthritis, [216]
content in gout, [189]
count in acute gout, [211]
Blood, examination of, in diagnosis of articular gout, [251]
Blood, human, relationship between amounts of uric acid, urea and non-protein nitrogen in, [122]
in chronic interstitial nephritis, urates in, [120]
in disease, uric acid of, [137]
portal, amino-acids in, [62]
routine examination of, in diagnosis of articular gout, [249]
uric acid as normal constituent of, [135]
uric acid content of, and gout, relation between, [143]
effect of diet upon, [141]
effect of exogenous purins on, [137]
estimation of sources of fallacy, [145]
in gout, [133], [139]
uric acid in, [24], [34], [78]
discovery of, [21]
Folin and Denis’s method of determination, [133]
forms of, [145]
Gudzent and Schade’s theories, [79]
non-protein nitrogen and urea nitrogen in (table), [136]
variations in uric acid content independently of diet, [142]
Bodily conformation, and gout, [44]
Boils, gout following, [53], [178]
Bone, conditions of, revealed by skiagraphy, in diagnosis of gout, [286]
Bones, changes in, in gout, [53]
focal areas of rarefaction in, revealed by skiagraphy, [286], [287]
Brandy in gout, [371]
Bruce’s modes, [286]
Bunion, inflamed, differential diagnosis from gout, [261]
Burian and Schur’s researches on sources of uric acid, [83]
Bursæ, involved in gout, [195]
tophi in, [233]
Bursitis, olecranon, gouty, [215]
post-calcaneal, in referred pain in heel, [265]
Cælius Aurelianus’s views on gout, [5]
Caffeine, [85]
Calcium carbonate in inter-paroxysmal periods of gout, [392]
salts in gouty tophi, [151]
Calculus, urinary, [29]
Carbohydrates in diet of gouty, [347]
Carbuncles, gout following, [53], [178]
Cartilage, morbid changes in, [53]
uratic deposits in, [52], [153]
in nephritis, [128]
Cataphoresis in treatment of chronic articular gout, [407]
Cell protoplasm, chemistry of, [176]
Celsus’s views on gout, [4]
“Chalk-stones,” [150]
Chalybeate waters, spas for, [442]
Champagne in gout, [368]
Charcot’s discovery of nerve arthropathies, [18]
joint, differential diagnosis from chronic articular gout, [277]
Chemistry of uric acid and purin bodies, [75]
Chilblains confused with early stages of tophi formation, [164]
Chirargra, Greek designation, [3]
Cholecystitis, [184]
Cider as beverage in gout, [363]
Claret in gout, [369]
Climate and gout, [45]
and residence in treatment of gout, [418]
Climato-therapy in gout, [418]
Clothing, importance of, [421]
Cocoa as beverage in gout, [361]
Coffee as beverage in gout, [361]
Colchicine in treatment of acute gout, [378]
Colchicum in acute gout, [192], [374], [375], [378]
contra-indicated, alkalies as substitute, [383]
method of administration, [376]
preparations and dosage of, [376]
used by Aetius, [6]
Colitis, mucous, initial manifestations of gout, [175]
Colloids in gouty tophi, [152]
Collosol iodine in treatment of chronic gout, [402]
Colorimetric method of determining uric acid in blood, [133]
Colour reaction test in blood analysis, [133]
Condiments in diet of gouty, [350]
Constipation, effect in gout, [337]
in acute gout, treatment of, [373]
in chronic gout, treatment of, [400]
in inter-paroxysmal periods of gout, treatment of, [393]
Constitutional disturbance in gout, [188]
influences in formation of tophi, [161]
Corpora cavernosa of penis, tophi in, [235]
Cramps in acute gout, [210]
Cream, effect of, on uric acid output, [348]
Creatine, [63], [67]
in urine of children, [68]
Creatinine, [61], [63], [67], [68]
in blood in gout and nephritis (table), [121]
Crystalline deposits in synovial fluid, [54]
Crystalloids in gouty tophi, [152]
Cytosine, [98]
Cullen’s differentiation of varieties of rheumatism, [16]
theory of ætiology of gout, [21]
Cutaneous disorders in gout, [240]
gravel, [203]
Cuticule, desquamation of, typical of gout, [191]
Cystin in urine, [59]
Cystinuria, [69]
Cystoid degeneration in gout, [56]
Deaminisation of amino-acids, [62], [63]
Deficiency diseases and accessory food factors, [340]
Degeneration, theories of, [25], [27]
Desquamation in acute gout, [212]
Diabetes, glycosuria and, [60]
Dicarboxylic amino-acids, [89]
Diet, effect of, on blood content of uric acid, [141]
Diet on excretion of uric acid, [83]
Diet in acute paroxysms of gout, [332]
in albuminuria, [358]
in amylaceous dyspepsia, [351], [352]
in chronic gout, [334]
in glycosuria, [357]
in hyperchlorhydria, [353]
in hyperuricæmia, [354]
in hypochlorhydria, [354]
in inter-paroxysmal periods of gout, [391]
in reduction of obesity, [357]
in treatment of gout, [332]
“accessory food factors,” [339]
carbohydrates, [347]
collaboration of clinician and bio-chemist, need for, [337]
condiments, [350]
fats, [347]
fish, [346]
fruits, [349]
idiosyncrasies of, [343]
physical examination necessary before, [336]
proteins, [345]
regulations of, [342]
vegetables, [348]
variations of blood content of uric acid independently of, [142]
Dietaries, fixed, fallacy of, in treatment of gout, [335]
Digestion, disturbances of, prevention of, in treatment of gout, [335]
Digestive glands, rôle of, in uric acid excretion, [88]
Diocletian, edict by, re gout, [5]
Dislocations, signalising attack of gout, [53]
Douches, [428]
Dover’s powder, with aspirin and phenacetin, in treatment of acute gout, [383]
Drink and gout, [48]
“Drug dyspepsia,” [391]
Drugs influencing excretion of endogenous uric acid, [96]
Duckworth’s classification of arthritic type of gout, [36]
theory of ætiology of gout, [33]
Dyschezia and gout, [337]
Dysenteric arthritis, differential diagnosis from acute gouty polyarthritis, [272]
Dysentery, complicated by arthritis and myalgias, [194]
Dyspepsia, amylaceous, diet in, [351], [352]
atonic, muriated waters in treatment of, [444]
chronic, gout associated with, [178]
“drug,” [391]
gouty, no specific form of, [350]
intestinal, preceding gout, [182]
mineral waters in treatment of, [443]
spas in treatment of, [442]
Dyspeptic symptoms of acute localised gout, [201]
Ear, pricking or tenderness in, [203]
tophus in, [202]
Ears, tophi in, antedating articular outbreaks, [203]
Ebstein and Sprague’s analysis of tophi, [150]
Ebstein’s theory of ætiology of gout, [25]
Ecchymoses, local, in acute gout, [212]
Eczema, gouty, spa treatment of, [451]
treatment of, [416]
in gout, [241]
Egypt, osteoarthritis in, in ancient times, [1]
Endemic areas of gout, [46]
Endogenous purins, [87]
origin of, [83]
source of, [88]
uric acid excretion, [91]
factors influencing, [93]
increased by purin-free proteid food, [89]
pathological states influencing, [94]
periodic variations of, [94]
physiological conditions, [93]
Environment in gout, [40]
Enzymes, distribution of, [99]
in intestinal juices and wall, [100]
Epistaxis, gout following, [178]
Epithelial cells, nucleus in gouty tophi, [151]
Erysipelas, gouty arthritis simulating, [215]
Erythromelalgia, differential diagnosis from gout, [266]
Etiological diagnosis of articular gout, [247]
Exercise in gout, importance of, [421]
relation of, to gout, [337]
Exogenous origin of purins, [83]
purins as source of uric acid, [84]
uric acid excretion, [85]
Exudative diathesis, [116]
Eye, deposition of urates in, [309]
gout in, evidence of, [309]
gouty diathesis in regard to, [310]
Eyelids, uratic deposits in, [235]
Fæces, examination of, in diagnosis of articular gout, [250]
in treatment of gout, [337]
Fasciæ, involved in gout, [195]
“Fat soluble A,” [340]
Fats in diet of gouty, [347]
Feet, incidence of tophi in, [162]
plantar surface of, tophi in, [235]
Fibrosis, interstitial, chronic, [186]
of visceral organs in gout, tendency to, [186]
Fibrositis associated with acute articular gout, [195]
associated with gout, treatment of, [411]
gouty, acute brachial, treatment of, [412]
incidence of gouty stigmata in types of, [221], [222]
muscular, in gouty, massage in, [423]
spa treatment of, [450]
Fingers, deformed, in chronic gout, [230]
pulps of, tophi in, [235]
Fischer’s researches on protein molecule, [61]
Fish in diet of gouty, [346]
Flatfoot, pains in, differential diagnosis from gout, [263]
“Flying gout,” [193]
Foci of infection in gouty, [53]
local, in gout, [177]
Foci, relation to gouty synovitis and arthritis, [185]
Folin and Denis’s method of determination of uric acid in blood, [133]
researches into urea formation, [63]
Food, cooking of, in diet of gouty, [344]
influence on gout, [48]
Foods, various, exogenous urinary purin in, amount of, [85]
Foot deformities, static, differential diagnosis from gout, [261]
“Fot-adl,” Anglo-Saxon name for gout, [3]
Fractures, signalising attack of gout, [53]
Fruits in diet of gouty, [349]
Function, gout a disorder of, [200]
Functional disturbances in gout, [201]
Galen’s views on gout, [2], [4]
Gall-stones, gout associated with, [184]
Gall-bladder dyspepsia, [184]
Garrod’s discovery of uric acid in blood of gouty persons, [21]
pathogeny of gout, growing scepticism as to, [32]
theory of ætiology of gout, [22]
views on gout in the eye, [320]
Gastralgias in gouty, [351]
Gastric catarrh, chronic, gout associated with, [351]
chronic, mineral waters suitable for, [445]
glands, diseased conditions of, and gout, [173]
insufficiency, muriated waters in treatment of, [444]
Gastro-intestinal asepsis, importance of, in gout, [332]
derangements in acute paroxysms of gout, [333]
disorders and gout, [180]
attributed to gout, [299-302]
chronic, spas in treatment of, [442]
mineral waters in treatment of, [443]
tract, derangement of, cause of gout, [170]
Genito-urinary passages, infection of, examination for, in diagnosis of articular gout, [249]
tract, examination of, in treatment of gout, [331]
Geographical distribution of gout, [45-48]
Gin in gout, [371]
Glandular affections in gouty subjects, [179]
Glaucoma, gout and, [324]
Glycocine and urea, interaction between, [84]
Glycocoll, rôle of, [64]
theory of gout, [65]
uric acid excretion augmented by, [89]
Glycosuria and diabetes, [60]
associated with gout, treatment of, [414]
diet in, [357]
examination for, in treatment of gout, [337]
gout and, co-existence of, [185]
gout in relation to, [236]
“gouty,” [182]
spa treatment of, [449]
Glyoxylic acid in gouty urine, [65]
Gonococcal arthritis of tarsus and metatarsus, differential diagnosis from gout, [263]
infection, articular involvement, with muscular and nervous lesions, [194]
differential diagnosis from gout, [259]
exclusion of, in diagnosis of articular gout, [248]
Gore, Ringrose, theory of pathology of gout, [173]
Gout, acute, colchicum in, [375]
definitely paroxysmal, [191]
general phenomena of, [210]
ionisation in treatment of, [387]
local phenomena, [211]
localised, clinical account, [200]
dyspeptic symptoms of, [201]
premonitory articular pains, [204]
prodromal symptoms, [200]
locality of, [208]
medicinal treatment of, [372]
onset of, [207]
pain in, [208]
paroxysm of, analysis of, [188]
diet in, [332]
symptoms of, [205]
uric acid variations in, [117]
surgical methods considered, [388]
treatment of, alternative remedies in, [381]
local measures, [384]
uric acid excretion in, [117], [211]
uric acid variations in, [108], [117]
ætiology of, histogenous theories of, [23]
nervous theories, [31]
summary of, [44]
theory of antecedent structural changes, [25]
age factor in, [40]
alcohol in, [361]
amino-acids in relation to, [64]
and fibrositis, incidence of, [221]
and granular kidney, clinical associations of, [130]
and immunity, early fallacies regarding, [10]
and nephritis, [242]
and other diseases, affinities between, [236]
and rheumatoid arthritis, resemblance between, [113]
and specific infective arthritides, analogies between, [194]
antiquity of, [1]
arterio-sclerosis associated with, [245]
articular, acute, differential diagnosis, [259]
localised, clinical diagnosis, [258]
chronic, [225]
alkalies in treatment of, [399]
blood changes in, [226]
clinical diagnosis of, [275]
distribution of, [226]
local measures in, [407]
medicinal and other modes of therapy, [397]
progress of disease, [228]
surgical treatment, [409]
classification of, author’s division, [38]
clinical diagnosis of, [252]
etiological diagnosis, [247]
manifestations of, [195]
as an infection, [177]
auto-intoxication theory, summary, [182]
beverages in, [359]
blood content in, [127]
uric acid and, relation between, [143]
choice of spa in treatment of, [440]
chronic, ankylosis in, [287]
confusion with chronic villous synovitis, [279]
diet in, [334]
differentiation of, from arthritis deformans, [16]
joint deformities of, [229]
of oligo-articular distribution, [278]
polyarticular, clinical features, [282]
polyarticular, differential diagnosis, [282]
tardy dissociation of, from chronic rheumatism, [15]
uric acid variations in, [109]
classification of, [35], [36]
climate and residence in treatment of, [418]
climato-therapy in, [418]
clinical account of, [200]
clothing and, [421]
collateral phenomena of, [219]
constipation and, [337]
cutaneous disorders in, [240]
definition of, [35]
author’s, [36]
derangement of gastro-intestinal tract as cause of, [171]
elimination of infective arthritides from domain of, [19]
endemic areas in, [46]
etiology of, [39]
evolution and life history of, [193]
excretion in, anomalies of, [112]
exercise in, importance of, [421]
false, ocular symptoms, [322]
glycocoll theory of, [65]
Greek physicians’ views of pathology of, [3]
growing infrequency and attenuation of, [12]
guanine, in swine, [100]
heredity and, [41]
hydrotherapy, general, in treatment of, [424]
local, in treatment of, methods of, [428]
hyperpyræmia in ætiology of, [30]
in big toe, differential diagnosis, [259]
infantile, [116], [305]
infective theory of, rise of, [171]
summary, [182], [183]
inflammatory phenomena in, cause of, [165]
initial attacks usually monarticular, [207]
initial outbreaks of, anomalous sites for, [267]
sites of, [37]
in relation to glycosuria, [236]
in relation to phlebitis, [239]
in the heel, [264]
in the instep, [262]
in the sole, [265]
inter-paroxysmal period, treatment in, prophylactic measures, [389]
introduction of word, [6]
irregular, [293]
conclusions regarding, [304]
isolation of acute articular rheumatism from, [15]
lead workers predisposed to, [50]
leanness in, [337]
leucocytosis in, [172], [189]
life history of, [193]
local foci of infection, [177]
treatment of, radical, [327]
local syncopes and asphyxias of hands in, [45]
long-continued, favouring onset of pre-senilism, [398]
lumbago associated with, [221]
massage, general, in treatment, [423]
metabolic phenomena correlated with postulated infective element, [195]
mineral springs in treatment of, [431]
monarticular, chronic, differential diagnosis of, [276], [277]
morbid anatomy of, [39], [53]
morbid conditions associated with, treatment of, [411]
obesity in, reduction of, [356]
ocular disease in, [308]
frequency a factor in diagnosis, [316]
onset of, symptoms, [188]
organic predisposition to, [43]
other conditions classified as, in early times, [12]
pathogenesis of, earlier theories of, [21]
pedigree of, [14]
periodicity of, [191]
phenomena of, detailed account of, [207]
predisposing causes of, summary of, [52]
prevalence of, in Anglo-Saxon period, [2]
prognosis in, [244]
renal theory of, [117]
restriction of, by elimination of other disorders, [19]
retarded purin elimination in, [118]
retention capacity of tissues for uric acid in, [158]
retrocedent, [39], [296]
irregular manifestations of, [299]
sex incidence of, [41]
skiagraphy in diagnosis of, [286]
specific organism suggested, [175]
sthenic, febrile stage of, alcohol and, [333]
structural changes, [54]
sub-infection theory, summary, [182], [183]
subjective phenomena of, in relation to blood content and excretion of uric acid, radium emanations and, [438]
“the honour of,” [8]
theory of hepatic inadequacy, [28]
tophaceous, [39]
treatment of, [327]
diet in, [332], [342]
fallacy of fixed dietaries, [335]
gastro-intestinal asepsis in, [332]
hyperæmia, [429]
physical examination necessary before dieting, [336]
prevention of digestive disturbances, [335]
uratic deposits in, [54]
differentiation from nephritis, [129]
localisation of, [153]
uratosis in relation to, [149]
urea excretion in, [66]
uric acid content of blood in, [139]
uric acid excretion in, [108]
anomalies in, [117]
uric acid in relation to, [107]
uric acid theory of, [21]
uric acid, urea and creatine in blood in (table), [211]
uricæmia in, [125], [133]
not cause, but result, of, [148]
variations in excretion in, diagnosis of, [60]
Gouty arthritis, definition of, [20]
phlebitis, [240]
polyarthritis, acute, [214]
stigmata in types of fibrositis, [222]
“Gravel, cutaneous,” [203]
immunity from, [29]
Greek physicians, terms used for forms of gout, [3]
views of pathology of gout, [3]
Guaiacum in treatment of chronic gout, [403]
resin, effects on urine, [405]
Guanase, [100], [101]
Guanine, [73], [75], [77], [98]
gout in swine, [100]
Gudzent and Schade’s theories of uric acid in blood, [79]
Gummata, peri-bursal, [281]
peri-synovial, [281]
Gums, recession of, early, [45]
Hæmatemesis, gout following, [178]
Hæmo-analysis, [147]
Hæmophilic arthritis, differential diagnosis from chronic gout, [285]
Hæmorrhage, retinal, and gout, [322]
Hair, premature whitening of, [45]
Hallux rigidus, differential diagnosis from gout, [262]
valgus with inflamed bunion, differential diagnosis from gout, [261]
Haly Abbas’s views on gout, [6]
Hand, gouty polyarthritis in, [214]
Hands, deformed, in chronic gout, [230]
incidence of tophi in, [162]
local syncopes and asphyxias in gout, [45]
palms of, tophi in, [235]
Hare’s theory of ætiology of gout, [30]
Heart affections in gouty subjects, [302]
Heberden’s differentiation of rheumatoid arthritis from gout, [17]
nodes, [41], [283]
Heel, gout in, [264]
referred pain in, differential diagnosis in, [264]
local sources of fallacy, [265]
Hepatic derangement in acute paroxysms of gout, [333]
inadequacy theory of ætiology of gout, [28]
Heredity in gout, [8], [28], [40], [41], [214]
Herpes in acute gout, [241]
Hexose group in vegetable nucleic acids, [98]
Hippocrates, aphorisms of, on gout, [4]
Histogenous theories of ætiology of gout, [23]
Historical survey, [1]
Horbaczewski’s experiments on uric acid, [73]
Hot-air baths, [429]
contra-indications to use of, [429]
Hutchinson on gout and rheumatism, [15]
Hydrarthrosis, bilateral, [281]
in chronic articular gout, [278]
Hydrochloric acid, secretion of, and gout, [173]
strong or fuming, in inter-paroxysmal periods of gout, [393]
variations in, and gout, [181]
Hydro-therapy, general, in treatment of gout, [424]
in acute gout, [385]
in treatment of gout, contra-indications and untoward complications, [425]
methods of application, [427]
prophylactic measures, [424]
local, in treatment of gout, [428]
Hyperacidity due to organic acids, [351]
in inter-paroxysmal periods of gout, [393]
Hyperæmia, treatment of gout by, [429]
Hyperchlorhydria, [181], [351]
associated with gout, treatment of, [415]
complicating gout, salt in diet contra-indicated, [350]
diet in, [353]
mineral waters suitable in treatment of, [446]
Hyperpyræmia in ætiology of gout, [30]
Hyperuricæmia, diet in, [354]
in gout, [140]
in non-gouty arthritis, [140]
ocular symptoms in, [321]
Hypochlorhydria, [351]
diet in, [354]
Hypoxanthine, [73], [75], [77]
Indigestion, intestinal, in gouty subjects, [181]
Infantile gout, [116], [305]
Infection in gout, local foci of, [177]
examination for in diagnosis of articular gout, [248]
theory of gout, [182], [183]
Infections, differential diagnosis from acute localised articular gout, [259]
specific, arthritic muscular and nerve lesions associated with, [195]
diagnosis of, [19]
Infective element in gout, correlated with metabolic phenomena, [195]
Inflammation and tophi formation, [164]
gouty, pus formation and, [191]
Inflammatory phenomena in gout, cause of, [165]
Influenzal arthritis, differential diagnosis from acute gouty polyarthritis, [272]
Immunity conferred by gout, early fallacies regarding, [10]
Inosinic acid, [93]
Instep, gout in the, [262]
Intestinal canal, source of microbe or toxin in gout, [181]
derangements, mineral waters suitable in treatment of, [448]
dyspepsia preceding gout, [182]
indigestion in gouty subjects, [181]
irrigation with radio-active waters, [439]
juices and wall, enzymes in, [100]
Iodides in treatment of chronic gout, [401]
value of, in renal and vascular changes, [403]
Iodine-albumen compounds in treatment of chronic gout, [402]
Iodo-glidine in treatment of chronic gout, [402]
Iodo-protein in treatment of chronic gout, [402]
Ionisation in treatment of acute gout, [387]
in treatment of chronic articular gout, [407]
Iritis, “arthritic,” [315]
diseases commonly associated with, [313]
gouty, “not” a clinical entity, [316]
in gout, [308]
relative incidence of, [313]
Irregular gout, [293]
Isomeric forms of uric acid, [81]
Isomers of purins, [81]
of pyrimidins, [81]
Jaw, formation of, [45]
Jaws, radiographs of, in treatment of gout, [328]
Joint cartilage, murexide reaction in, [153]
deformities of, chronic gout, [229]
Joints, diaphyses of, cystic changes in, [56]
rheumatism of, [14]
stiffness of, after acute attacks of gout, [212]
swellings, local character of, in osteo-arthritis, [283]
local character of, in rheumatoid arthritis, [284]
tophi in, [233]
Juices, gastric and intestinal, gout and, [173]
Kidney and kidneys, capacity of for eliminating uric acid, [125]
condition of, effect in blood content of uric acid, [138]
disease of, granular, and gout, clinical, association, [130]
joint examination in, results of, [129]
disease of, and gout, [242]
functionally deficient in late stage of gout, [119]
functional disorders of, [27], [28]
functional efficiency of, tests for, [338]
gouty, histological changes in, [127]
guanase in, [100]
uric acid elimination in, [119]
Knee, gouty polyarthritis in, [214]
site of primary attack of gout, [267]
Kossel’s discovery of purin bases, [73]
Labile protein, [59]
Latham’s theory of hepatic origin of gout, [29]
“Lead gout,” [50]
Lead, elimination by iodides, [403]
poisoning, blood content in, [122], [123], [127]
ocular symptoms in, [321]
purin metabolism in, [115]
workers, predisposed to gout, [50]
Leanness in gout, [337]
Lehmann’s analysis of tophi, [150]
Leucocytosis, [24], [27]
during acute attacks of gout, [172]
in gout, [189]
in gouty polyarthritis, [216]
relation to uric acid excretion, [95]
Leucopenia, [96]
in gout, [189]
Leukæmia, blood content in, [122], [123]
ocular symptoms in, [321]
uric acid in urine in, [95]
Levy’s (Magnus) researches on gout, [107]
Limbs, integument of tophi in, [235]
Lime salts, focal absorption of, in bones, [288]
Liniments in treatment of acute gout, [386]
Literature of various periods, references to gout in, [3]
Lithæmia, [294]
tendency to, [28], [33]
Lithiasis, [29]
Lithium salts in treatment of chronic gout, [400]
Lithuria, [29]
Liveing’s theory of ætiology of gout, [31]
Liver, diseases of, amino-acids in, [59]
disorders of, functional, mineral waters suitable in treatment of, [447]
enzymes in, [99]
functional efficiency of, tests for, [338]
glycogenic distension of, [31]
guanase in, [100]
main centre of production of urea, [63]
Living, style of, effect on incidence of gout, [2]
Locality, factor in gout, [45]
incidence of, in acute gout, [208]
Lucian of Saramosta’s views on gout, [4]
Lumbago, associated with gout, [221]
treatment of, [411]
Lung, guanase in, [100]
Lymph spaces, purins in, [146]
stream, sodium ions in, [146]
Lymphangitis, co-existent with gout, [58]
in gout, [190]
Lymphatic gland, enlargement of, in gout, [190]
Lymphatics, purins in, [146]
Malt liquors in gout, [362]
Marchand’s analysis of tophi, [150]
Massage, general, in treatment of gout, [423]
in after-treatment of acute gout, [385], [387]
McCarrison’s views on effect of absence of vitamines on functional efficiency, [340]
McClure and McCarty’s researches on bone conditions as revealed by skiagraphy, [288], [289]
Meat, over-eating of, functional damage resulting from, [65]
Meningococcal arthritis, differential diagnosis from acute gouty polyarthritis, [272]
Menstruation, effect of, on incidence of gout, [41]
Mental over-exertion and gout, [51]
Metabolic phenomena of gout correlated with postulated infective element, [195]
Metabolism, alterations in, [30]
inborn errors of, [69]
nuclein, [71]
protein, [59], [61]
Metastasis in relation to ocular gout, [314]
gouty, [297]
Metatarsalgia, differential diagnosis from gout, [262]
Methyl-purins as source of uric acid, [85]
Microbic theory of gout, [175]
Miescher’s researches on spermatozoa, [72]
on the nucleus, [71]
Milk diet in acute paroxysms of gout, [332]
Mineral springs, [431]
waters as beverage in gout, [360]
Monarticular gout, differential diagnosis of, [276], [277]
Morphia, hypodermic injections of, in acute gout, [383]
Mouth, examination of, in diagnosis of articular gout, [248]
in treatment of gout, [328]
local foci of infection, results of, [184]
Murchison’s theory of ætiology of gout, [28]
Murexide reaction in joint cartilage, [153]
Muriated chloride waters, spas for, [441]
sulphated waters, spas for, [442]
Muscles, affections of, in gout, [195]
voluntary, relation of creatinine to, [68]
Muscular exercise, uric acid excretion increased by, [93]
Myeloma, waste of albumoses in, [59]
Nails, striated, fluted and brittle, [45]
Nasal affections, radium emanations for, [438]
disorders, gout and, [178]
Naso-pharynx, examination of, in treatment of gout, [328]
foci of infection, [53]
Necrosis, local, in uratic deposition, [152]
relationship to gout, [25]
Nephritis, acute and chronic, blood content in, [127]
chronic, spa treatment of, [452]
complicating gouty polyarthritis, [219]
early, blood content of uric acid, urea and creatine, similarity to gout, [120]
gout and, [242]
gouty, treatment of, [416]
uratic deposits in, [128]
differentiation from gout, [129]
uric acid, urea and creatine in blood in (table), [121]
uricæmia in, [120]
uricæmia not peculiar to, [124]
Nerve arthropathies, differential diagnosis from chronic gout, [284]
Charcot’s discovery of, [18]
Nervous phenomena of gout, [188], [304]
system, effect of gout on, [219]
theories of ætiology of gout, [31]
Neuralgia, plantar, differential diagnosis from gout, [266]
Neuritis, alcoholic peripheral, [238]
glycosuric peripheral, [238]
Neuro-lymphatismus, [116]
Neuro-retinitis in the gouty, [324]
Neurosis, gouty, [31]
Neuroses, paroxysmal, of gout, [188]
Nose, alæ of, tophi in, [235]
Nuclease, [100]
Nucleic acid, [72], [77]
characteristic constituents of, [78]
disruption of, [100]
in body, [74]
formation of uric acid from, [98]
isolation of, [71]
metabolism of, in gout, [69]
molecules, [101]
of animal origin, structural formula of, [99]
physiological derivation of uric acid from, [73]
uric acid a derivative of, [73]
Nucleic-acidase, [100]
Nuclein, discovery of, [72]
metabolism, [71]
chemistry of, [60]
Nucleins, [77]
phosphoric acid group in, [112]
Nucleo-proteins, [77]
Nucleosidases, [101]
Nucleosides, [87], [100]
Nucleotidase, [100]
Nucleotides, [100]
Numbness after acute attacks of gout, [212]
Obesity and gout, [245]
Ebstein’s views of affinity, [280]
in gout, [337]
reduction of, [356]
Occupation and gout, [48]
Occupations predisposing to gout, [50]
Ocular disease in gout, [308]
Œdema in acute gout, [212]
in gouty conditions, [191]
Olecranon bursa, involved in gout, [215]
tophi in, [233], [235]
Oligo-articular distribution of chronic gout, [278]
Oral sepsis in gouty subjects, [179]
radium emanations and, [438]
treatment of, in gout, [330]
Ord’s theory of ætiology of gout, [25]
Osler’s views on gout, [36]
Osteoarthritis, acute, differential diagnosis from gout, [261]
and chronic articular gout, [275], [276]
co-existing with gout, [19]
differential diagnosis from chronic articular gout, [278]
differential diagnosis from chronic gout, [283]
in ancient civilisations, [1]
local characters of joint swellings, [283]
of hip, with auricular tophi, [226]
skiagraphy in differential diagnosis of, [291]
Overeating and gout, [48]
plus alcohol, cause of gout, [49]
Oxaluria associated with gout, treatment of, [413]
examination for, in treatment of gout, [337]
spa treatment of, [449]
Oxidation of purin, products of, [77]
Oxy-purins as source of uric acid, [84]
formation of, [102]
Pain and tophi formation, [164]
in acute gout, [208]
in auricular tophi, [233]
referred, in heel, differential diagnosis of, [264]
Pains, premonitory articular, in acute localised gout, [204]
Painters, predisposed to gout, [50]
Pancreas, enzymes in, [99]
Pancreatic inefficiency, evidence of, in diagnosis of articular gout, [250]
Pancretin, [392]
Papain, [392]
Parke’s theories of ætiology of gout, [23]
Parotitis, acute, gout following, [53]
in gout, [179]
Patella, tophi in, [235]
Pathological states influencing endogenous uric acid excretions, [94]
Paulus Ægineta’s views on gout, [6]
Pedigree of gout, [14]
Pentosuria, [69]
Peri-bursal gummata, [281]
Perineum, uratic deposits in, [235]
Periodic variations in excretion of endogenous uric acid, [94]
Periodontitis, chronic, [329]
Peri-synovial gummata, [281]
Pes planus, differential diagnosis from gout, [263]
Pharyngeal affections, radium emanations for, [438]
Pharyngitis, acute and chronic, in gouty subjects, [179]
acute, gout following, [53]
Pharynx, examination of, in diagnosis of articular gout, [249]
Phlebitis, gout in relation to, [239]
gouty, treatment of, [415]
in limb in articular gout, [190]
spa treatment of, [450]
treatment of gout and, [328]
Phospho-nuclease, [102]
Physical examination, necessity for, before dieting, in treatment of gout, [336]
over-exertion and gout, [51]
Physiognomy of the goutily disposed, [44]
Pinna, small red swellings on, [204]
Planchon’s views on gout, [6]
Plantar neuralgia, differential diagnosis from gout, [266]
Pleurodynia associated with gout, treatment of, [412]
Plumbers, predisposed to gout, [50]
Plumbism and gout, [60]
purin metabolism in, [115]
Pneumococcal arthritis, differential diagnosis from acute gouty polyarthritis, [272]
Podagra, [12]
Greek designation, [3]
Polyarthritis, articular, acute, differential diagnosis of, [269], [270]
gouty, acute, [214]
clinical diagnosis of, [268]
diet in, [334]
blood changes in, [216]
distribution of, [214]
effect on nervous system, [219]
simulating erysipelas, [215]
non-gouty, uric acid blood content in, [141]
Polyarticular distribution of gout, [214]
Poly-nucleotides, [100]
Port wine in gout, [364], [368]
Portal blood, amino-acids in, [62]
Post-critical stage of depression, [211]
Potash compounds in treatment of chronic gout, [400]
Potassium in gouty tophi, [151]
Prescriptions for use in acute gout, [375], [377], [378], [379], [380], [386], [391]
for use in chronic gout, [401], [405], [406]
for use in inter-paroxysmal periods of gout, [391], [392], [393], [394]
Pre-senilism, long-continued gout favouring, [398]
Protamine, [72]
Protein, amino-acids in, number of, [64]
chemistry of, [60]
labile, [59]
metabolism, [59], [61]
urine content of urea, etc., in, [59]
tissue, [59]
Proteins and their derivatives, [88]
in diet of gouty, [345]
Pulse quickened in gout, [189]
Purgatives in treatment of acute gout, [374]
Purin bases, toxicity of, discussed, [168]
bodies, [34], [48], [63]
chemistry of, [75]
diet, uric acid excretion in, [86]
“free” diet, [355]
uric acid blood content in, [137]
uric acid excretion in, [86]
elimination, retarded, in gout, [118]
metabolism, chemistry of, [60]
in chronic alcoholism, [115]
in other disorders, [113]
in plumbism, [115]
nuclease, [102]
nucleus, arrangement of atoms, [76]
oxidation of, products of, [77]
scheme illustrating probable stages in passage through body, [101]
synthesis in mammals, [97]
unexcreted, fate of, [87]
Purins, discovery of, [72]
endogenous, [83], [87]
source of, [88]
exogenous, [83]
as source of uric acid, [84]
effect of atophan on, [110]
effect on uric acid blood content, [137]
isomers of, [81]
of vegetable origin, [77]
Pus formation, non-existence of, in gouty inflammation, [186], [191]
Pyæmia, differential diagnosis from gout, [259]
Pyæmic conditions confounded with gout, [191]
Pyorrhœa alveolaris, and gout, [178]
and treatment of gout, [329]
exclusion of, in diagnosis of articular gout, [248]
Pyrexia in acute gout, [210]
in gout, [189]
Pyrimidine bases, [77]
Pyrimidins, isomers of, [81]
Quadriurate in blood, [78], [79]
Quinic acid in treatment of acute gout, [383]
Quinine in treatment of acute gout, [383]
Race incidence of gout, [45-48]
Radio-active properties of thermal waters, [427]
waters, physical properties of, [434]
Radium emanation, increased excretion of uric acid through, [437]
influence on uric acid metabolism, [436]
physiological action of, [435]
subjective phenomena of gout in relation to blood content and excretion of uric acid and, [438]
therapeutic action and application, [438]
Regular gout, [13]
Renal changes in gout, [54]
defect, uricæmia not necessarily due to, [123]
depression, functional, [119]
disease, abnormal protein loss in, [59]
theory of gout, [117]
uric acid infarcts, [151]
Residence, choice of, [420]
Respiratory disorders, spa treatment of, [450]
organs, affections of, in gout, [303]
Retinitis, nephritic, [324]
Retrocedent gout, [39], [296]
Rhazes’s views on gout, [6]
Rheumatism, acute articular, differential diagnosis from acute gouty polyarthritis, [269], [270]
isolation from gout, [15]
muscular and nervous lesions associated with, [194]
confused with gout, [215]
chronic, tardy dissociation of, from chronic gout, [15]
differential diagnosis from gout, [259]
early use of term, [14]
muscular, identification of, [16]
Rheumatoid arthritis, [17]
and gout, resemblance between, [113]
differential diagnosis from chronic gout, [284]
disturbance of purin metabolism in, [112]
or atrophic arthritis, differential diagnosis from acute polyarticular gout, [272]
Roberts’, Sir William, views on gout, [36]
Salicylate group as alternative remedy in treatment of acute gout, [381]
of colchicine in treatment of acute gout, [379]
Salicylates in treatment of acute gout, contra-indicated, alkalies as substitute, [383]
in treatment of chronic gout, [401]
Salisbury diet in hyperchlorhydria, [353]
method in reduction of obesity, [357]
Salt in diet of gouty, [350]
Scapular region, uratic deposits in, [235]
Scheele’s discovery of uric acid, [8]
Schnee four-cell bath in ionisation, [408]
Sciatica associated with gout, treatment of, [411], [412]
Scudamore’s definition of gout, [35]
Seneca’s views on gout, [5]
Septic conditions confounded with gout, [191]
Serapion’s views on gout, [6]
Serous membranes, uratic deposits in, in nephritis, [128]
Sex incidence in gout, [41]
Shivering at onset of acute paroxysm of gout, [188]
Sidonal in treatment of acute gout, [383]
Silk as underwear, [421]
Sinusitis, latent, cause of systemic infections, [331]
Skiagraphy in diagnosis of gout, [286]
in diagnosis of villous synovitis, [281]
in differential diagnosis of hypertrophic or osteo-arthritis, [291]
in differential diagnosis of infective arthritis, [290]
in differential diagnosis of rheumatoid or atrophic gout, [291]
Skin, action of, consideration of, in treatment of gout, [337]
appearances of, and gout, [45]
defective elimination by, in chronic gout, treatment of, [400]
Sodium biurate crystals in synovia, [52]
ions in lymph stream, [146]
mono-urate compound, [81]
salicylates of, in treatment of acute gout, [382]
Sole, gout in, [265]
Solubilities of uric acid and urates in gouty blood, [82]
Sool-Bader baths, [427]
Spa, choice of, in treatment of gout, [440]
treatment, duration of course of, [453]
in acute gout, [385]
of gout, principles of, [434]
remarks on, [452]
Spas from a national aspect, [454]
Spermatozoa, Miescher’s researches in, [72]
Spirits in gout, [370]
Spleen, enlargement of, in gout, [190]
enzymes in, [99]
functional efficiency of, tests for, [338]
Starchy foods in diet of gouty, [347]
Static foot deformities, differential diagnosis from gout, [261]
Stone in Norfolk, [29]
Streptococci in tonsils, [183]
Sub-infection theory of gout, [182], [183]
Sub-thermal baths, [428]
Succus entericus, action on nucleic acid, [100]
Sugar in diet of gouty, [347]
Sulphated alkaline waters, spas for, [442]
waters, [441], [442]
Sweetbreads in diet of gouty, effect of, [345], [346]
Swine, guanine gout in, [100]
Sydenham’s differentiation of rheumatism from gout, [15]
views on gout, [7]
Syncopes, local, of hand, in gout, [45]
Synovia, appearance in, in acute gout, [52]
Synovial fluid, reaction of, [52]
Synovitis, gouty, relation to local foci of infection, [185]
gummatous, differential diagnosis from chronic articular gout, [277]
of knees, differential diagnosis from gout, [264]
of tendo Achilles in referred pain in heel, [265]
perforative, [57]
villous, chronic, confusion with chronic gout, [279]
clinical symptoms of, [280]
static and non-gouty in origin, [280]
Synthetic formation as source of uric acid, [84]
of uric acid, [96]
Syphilis, articular, muscular and nerve lesions associated with, [194]
Syphilitic arthritis, secondary, differential diagnosis from acute gouty polyarthritis, [271]
disease of tarsal joints, differential diagnosis from gout, [263]
Taka-diastase, [392]
Tarsal joints, gonococcal arthritis of, differential diagnosis from gout, [263]
involved in gouty polyarthritis, [214]
tuberculous and syphilitic disease of, differential diagnosis from gout, [263]
Tartareous nature of tophi, views on, [8]
Tea as beverage in gout, [361]
Teeth, characteristic, in gout, [45]
conditions in gout, [178]
devitalised, examination of, in treatment of gout, [328]
foci of infection, [53]
Temperament, and gout, [44]
Temperature curve of gout, [188]
Tendo Achilles, involved in gout, [215]
Tendon sheaths, involved in gout, [195]
Tendons, gouty polyarthritis in, [214]
uratic deposits in, [153]
Test meals for HCL variations, [336]
Tests, modern, for uric acid determination, disabilities of, [147]
Theobromine, [85]
Theophyllin, [85]
Throat, gouty, [45]
Thymine, [98]
Thyminic acid, [80]
in treatment of acute gout, [383]
Thymus, enzymes in, [99]
gland, nucleic acid derived from, [98]
in diet of gouty patients, effect of, [345], [346]
Tibia, tophi in skin over, [235]
Tissue affinities for uric acid, [157]
protein, [59]
Tissues, human, concentrations of uric acid in, [159]
retention capacity of, for uric acid, [158]
effect on blood content, [138]
Toe, big, gout in, differential diagnosis of, [259]
initial outbreak of gout in, [37], [188]
Tonsil, site of infection in gout, [180]
Tonsillar sepsis, gout and, [178]
Tonsillitis, acute, gout following, [53]
in gouty subjects, [179]
treatment of, in gout, [330]
Tonsils, examination of, in diagnosis of articular gout, [249]
foci of infection, [53]
streptococci in, [183]
Tophaceous deposits in chronic articular gout, [227]
gout, [39]
Tophi, analysis of, [150]
antedating articular attacks, [202]
auricular, [202]
pain in, [233]
clinical evolution of, [162]
constitution of, [149]
constitutional influences in, [161]
diagnostic status of, [252]
difficulty in detecting, [256]
early stages of, confused with chilblains, [164]
early views as to nature of, [7]
evolution and distribution of, [231]
formation preceding arthritic attacks, [164]
frequency of, in gouty arthritis, [255]
gouty, causation of, [154]
formation of, [151]
localisation of, [153]
radiating, concentric and laminated structure of, [152]
urate of soda, [150]
importance of, in diagnosis of acute gouty polyarthritis, [269]
in diagnosis of gout, [38]
in eyes, significance of, [311]
inflammatory nature of swellings in, [163]
in relation to arthritis, [254]
in relation to uricæmia, [155]
sites of, [233]
stage of small red swellings, [163]
treatment of, in chronic articular gout, [407]
Tophus formation in acute gout, [212]
premonitory symptoms of, [203]
in ear, sign of gout, [202]
Trauma, local, effect on gout, [53]
Traumatic lesions, differential diagnosis from gout, [260]
Trousseau’s views on gout, [36]
Tuberculous disease of tarsal joints, differential diagnosis from gout, [263]
joint disease, differential diagnosis from chronic articular gout, [277]
Toxæmia, alimentary, hydrochloric acid, [394]
chronic, [182]
Toxicity, low, of chemical products, in gout, [69]
non-, of uric acid, [166]
Ulna, tophi in skin over, [235]
Uracil, [98]
Urate of soda in gouty tophi, [150]
Urates, deposition of, in eye, [309]
Uratic depositions as criterion of gout, [37]
deposits in gout, [54]
in gout and nephritis, differentiation of, [129]
in gout, localisation of, [153]
in nephritis, [128]
Uratosis in gout, [149]
Urea and glycocine, interaction between, [84]
end-product of protein metabolism, [63]
excretion in gout, [66]
excretion of ammonia as, [63]
formation of, [62]
Folin and Denis’s deductions, [64]
seat of, [63]
in blood in gout and nephritis (table), [121]
Ureters, ligature of, [26]
Uric acid, [75], [77]
a normal constituent in blood, [135]
an end-product, [70]
as a derivative of nucleic acid, [73]
blood content of, in various animals, [135]
variations independently of diet, [142]
chemical constitution of, [75]
concentrations in human tissues, [159]
content of blood and attacks of gout, relation between, [143]
in gout, [139]
deposition of, [22], [34]
destruction of, [98], [104]
determination of, disabilities of modern tests, [147]
diathesis, [294], [295]
discovery of, by Scheele, [8]
estimation of, sources of fallacy, [145]
excretions of, amount of, [75]
exogenous, [85]
in acute gout, [211]
in gout, [108]
anomalies in, [117]
increased by radium emanation, [437]
relation of leucocytosis to, [95]
exogenous purins as source of, [84]
formation of, Amberg and Jones’s scheme of, [103], [104]
from nucleic acid, [98]
gravel, spa treatment of, [451]
in the blood, [78]
forms of, [145]
in gout and nephritis (table), [121]
of gouty patients, discovery of, [21]
organic combinations of, [79]
infarcts, renal, [151]
in relation to gout, [107]
isomeric forms of, [81]
kidney capacity for eliminating, [125]
metabolism, influence of radium emanations on, [436]
non-toxicity of, [166]
of blood in disease (table), [137]
output, endogenous, lowered, [111]
exogenous, retarded, [109]
physical properties of, [78]
retention, capacity of tissues for, [158]
solubilities of, [154]
sources of, [83]
synthetic formation of, [84], [96]
theory of gout, [21]
tissue affinities for, [157]
variations in acute gout, [108]
variations in chronic gout, [109]
Wollaston’s researches on, [8]
Uric-acidæmia, [295]
Uricæmia and gout, [125]
in gout, [133]
in nephritis, [120]
not cause, but result, of gout, [148]
not necessarily due to renal defect, [123]
not peculiar to nephritis, [124]
significance of, [145]
tophi in relation to, [155]
Uricase, [87], [104]
absence of, in man, [104]
Uricolysis, [104]
Uricolytic enzyme, [105]
ferment, absence or diminution of, [106]
Urine, alkapton in, [59]
analysis of, in metabolism of gout, [113]
in treatment of gout, [337]
children’s, creatine in, [68]
cystin in, [59]
effects of guaiacum resin on, [405]
examination of, in diagnosis of articular gout, [250]
gouty, glyoxylic acid in, [65]
human, daily excretion of uric acid, amount of, [83]
scanty, before paroxysm of gout, [205]
Urosin in treatment of acute gout, [383]
Vaccine therapy in treatment of gout, [331]
Vapour baths, [428]
Vegetable cells, nucleic acid derived from, [98]
Vegetables in diet of gouty, [348]
Veins, engorged, before paroxysm of gout, [205]
Venesection, [4]
gout following, [178]
Vichy bath, [428]
Vidal’s atrophic form of arthritis deformans, [18]
Vinegar in diet of gouty, [350]
Viscera, functional capacity of, tests of, [338]
Visceral organs, tendency to fibrosis in gout, [186]
Vitamines, [340]
Volumetric method of determination of uric acid in blood (Curtman and Lehrman), [134]
Vomiting in acute paroxysms of gout, [333]
Wade’s theory of nervous origin of gout, [32]
Water, hot, advantages of, [360]
value of, as beverage in gout, [359]
“Water-soluble B,” [340]
“Water-soluble C,” [340]
Watson’s (Chalmers) researches on gout, [107], [172]
Weir-Mitchell method in reduction of obesity, [357]
Whisky in gout, [364], [370]
Wines as beverages in gout, [364]
general rules, [367]
individual and, [365]
importance of quality of, [366]
Wollaston’s researches on uric acid, [8]
Wrist, site of primary attack of gout, [267]
Xanthine, [75], [77]
Xanthine-oxidase, [99]
Xanthosine-hydrolase, [102]
X-ray examination of alimentary tract in treatment of gout, [336]
Yeast, nucleic acid derived from, [98]

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