In 1748 Pedro del Barrios Jacinto y Esprilla, an Alcolade of the Santo Hernando of all New Spain, was appointed the new Governor of Los Adais. The humdrum life of the frontier was too much for the new Governor so he gave up his position to Jacinto de Barrios y Gauregui in 1750. Barrios remained as governor until 1759, having had the fortitude to be Governor of Los Adais for a longer span of time than any of his predecessors. By now third generation Spaniards were being born on the Texas frontier from San Antonio De Bexar to Los Adais. These people were experiencing a new freedom not felt anywhere else in New Spain. They now regarded this land of Texas as their own. The seat of government was too far away to exercise a cloistered, ruling hand over them.
In 1759 Angle de Martos y Navarette replaced Jacinto Barrios as Governor of Los Adais. Navarette was a merchant and began to liven the frontier. Up to this time the French were supplying the area with all needed material, but when the new Governor came, fine Spanish lace, woolens and linen, finer than any which had previously been offered for sale on the frontier, and nails, which had always been scarce on the frontier, became plentiful.
In 1762 Louis XV gave Louisiana to his cousin Charles III of Spain.
In 1762 Caesar De Blanc was replaced at Natchitoches by Adrian Francois Le Doux as Post Commandante. He was in turn replaced by Angelus La Perrier in 1764. Perrier was the Commandante who received the first Catholic nuns to arrive in Natchitoches; thus 1765 marked the date of the beginning of formal scholastic training in the area.
Through his merchandising endeavors on this French-Spanish frontier Navarette had amassed for himself an estimated eighty thousand dollar fortune. In 1767 Don Hugo O’Connor was appointed Governor of the Adais and Texas country, and in November of that year, on the seventh day, Commandante La Perrier had the sad responsibility of turning over the Natchitoches Post to Don Antonio Ulloa representing the Spanish Government. In this same year O’Connor received a visitor, Padre Jose de Solice, who kept a diary of his visitation which was translated by Reverend Peter T. Forristal and was published as one of the preliminary studies of the Texas-Coahuila Historical Society.
Father Solice records the work of the priests of the Mission de Los Adais. There were 256 baptisms, 64 marriages and 116 burials. At the Natchitoches Post he found records of 20 baptisms, 13 marriages and 15 burials. (Natchitoches was quite often without the services of a priest and the padres of Los Adais supplied their spiritual needs).
Also, in 1767 Athanase De Mezieres, a Frenchman, was appointed Commandante of Post St. Jean Baptiste Des Natchitoches.
In 1770 Baron de Ripperda was appointed Governor of Los Adais and it befell his duty to see to the evacuation of Presidio Senors del Pilar de Los Adais. The Spanish authorities decided that now that the Louisiana Territory was entirely under Spanish jurisdiction, this presidio was no longer necessary.[9]
Ripperda issued orders that all settlers and army personnel were to be ready in three days to leave the area. Many of the farmers fled to the Natchitoches area with their families and worldly goods.
With Natchitoches now the seat of Government of the Texas area westward to San Antonio, El Camino Real was lengthened at least fifteen miles in extent from Natchitoches to Mexico City. De Mezieres had under his jurisdiction an area extending from Post Du Rapides (Alexandria) to the Ataquapois in Oklahoma southward to San Antonio.