9. It does not especially belong to or affect any particular sex, race, or class of persons.
10. It is not confined to any location or section of the earth, but has been observed in all countries and climates.
11. No single cause of cancer has yet been demonstrated, nor is it likely that this will ever be the case, as the experimental and other investigations have covered almost every possible line of research, with only negative results.
12. The exclusion of almost every other possible cause of cancer, as well as its pathological history, leads to deranged metabolism as the only remaining possible etiological element; this acts by inducing changes in nutrition, which latter depends on diet and the proper action of the secretory and excretory organs, which, still further, may be affected by nervous influences.
13. While the bio-chemistry of cancer throws little light on its true nature, enough is known to show that the morbid changes in the cells are largely associated with deranged metabolism.
14. The blood, in advancing cancer, manifests changes which indicate vital alteration in the action of the organs which form blood and control the nutrition of the body and its cells.
15. Clinical and experimental evidence demonstrate that the secretions and excretions of the body exhibit departures from normal, which, while not pathognomonic of cancer, indicate metabolic disturbances involving the nutrition of the cellular elements, which disturbances are of importance.
16. The evidence seems certain that the cancer mass itself, when fully developed, secretes a poison which tends to augment its own growth and hastens the lethal progress of the disease.
17. Cancer mortality is undoubtedly on the increase in every portion on the globe.
18. This increase seems to vary inversely with the decline of tuberculosis, in many localities.