This became obvious at the first interview of Wolsey with the imperial envoys, foremost amongst whom was Gattinara. They were commissioned to treat about the marriage of Charles with the Princess Mary, and about a secret undertaking for war against France; but their instructions contained nothing tending to peace. The French envoys were more pacific, as war was not popular in France.

On 7th August the conference was opened under Wolsey's presidency; but Gattinara did nothing save dwell upon the grievances of his master against France; he maintained that France had been the aggressor in breaking the existing treaty; he had no powers to negotiate peace or even a truce, but demanded England's help, which had been promised to the party first aggrieved. The French retorted in the same strain, but it was clear that they were not averse to peace, and were willing to trust to Wolsey's mediation. Wolsey saw that he could make little out of Gattinara. He intended to visit the Emperor, who had come to Bruges for the purpose, as soon as he had settled with the imperial envoys the preliminaries of an alliance; now he saw that the only hope of continuing the conference lay in winning from Charles better terms than the stubborn Gattinara would concede. So he begged the French envoys to remain in Calais while he visited the Emperor and arranged with him personally for a truce. As the French were desirous of peace, they consented.

On 16th August Wolsey entered Bruges in royal state, with a retinue of 1000 horsemen. Charles came to the city gate to meet him, and received him almost as an equal. Wolsey did not dismount from his horse, but received Charles's embrace seated. He was given rooms in Charles's palace, and the next day at church Charles sat by Wolsey's side and shared the same kneeling stool with him. Their private conferences dealt solely with the accord between England and the Emperor. Wolsey saw that it was useless to urge directly the cause of peace, and trusted to use for this purpose the advantages which his alliance would give. He succeeded, however, in considerably modifying the terms which had been first proposed. He diminished the amount of dowry which Mary was to receive on her marriage, and put off her voyage to the Emperor till she should reach the age of twelve, instead of seven, which was first demanded. Similarly he put off the period when England should declare war against France till the spring of 1523, though he agreed that if war was being waged between Francis and Charles in November, England should send some help to Charles. Thus he still preserved England's freedom of action, and deferred a rupture with France. Every one thought that many things might happen in the next few months, and that England was pledged to little. Further, Wolsey guarded the pecuniary interests of Henry by insisting that if France ceased to pay its instalments for the purchase of Tournai, the Emperor should make good the loss. He also stipulated that the treaty should be kept a profound secret, so that the proceedings of the conference should still go on.

Wolsey was impressed by Charles, and gave a true description of his character to Henry: "For his age he is very wise and understanding his affairs, right cold and temperate in speech, with assured manner, couching his words right well and to good purpose when he doth speak." We do not know what was Charles's private opinion of Wolsey. He can scarcely have relished Wolsey's lofty manner, for Wolsey bore himself with all the dignity of a representative of his king. Thus, the King of Denmark, Charles's brother-in-law, was in Bruges, and sought an interview with Wolsey, who answered that it was unbecoming for him to receive in his chamber any king to whom he was not commissioned; if the King of Denmark wished to speak with him, let him meet him, as though by accident, in the garden of the palace.

When the provisions of the treaty had been drafted, Wolsey set out for Calais on 26th August, and was honourably escorted out of Bruges by the Emperor himself. On his return the business of the conference began, and was dragged on through three weary months. The imperial envoys naturally saw nothing to be gained by the conference except keeping open the quarrel with France till November, when Henry was bound to send help to the Emperor if peace were not made. Wolsey remained true to his two principles: care for English interests, and a desire for peace. He secured protection for the fishery of the Channel in case of war, and he cautiously strove to lead up both parties to see their advantage in making a truce if they could not agree upon a peace. It was inevitable that these endeavours should bring on Wolsey the suspicions of both. The French guessed something of the secret treaty from the warlike appearance which England began to assume, and cried out that they were being deceived. The imperial envoys could not understand how one who had just signed a treaty with their master, could throw obstacles in their way and pursue a mediating policy of his own. Really both sides were only engaged in gaining time, and their attention was more fixed upon events in the field than on any serious project of agreement.

When in the middle of September the French arms won some successes, Gattinara showed himself inclined to negotiate for a truce. The conference, which hitherto had been merely illusory, suddenly became real, and Wolsey's wisdom in bargaining that England should not declare war against France till the spring of 1523 became apparent. He could urge on Gattinara that it would be wise to agree to a truce till that period was reached; then all would be straightforward. So Wolsey adjourned the public sittings of the conference, and negotiated privately with the two parties. The French saw in a year's truce only a means of allowing the Emperor to prepare for war, and demanded a substantial truce for ten years. Wolsey used all his skill to bring about an agreement, and induced Gattinara to accept a truce for eighteen months, and the French to reduce their demands to four years. But Charles raised a new difficulty, and claimed that all conquests made in the war should be given up. The only conquest was Fontarabia, on the border of Navarre, which was still occupied by the French. Francis not unnaturally declined to part with it solely to obtain a brief truce, as Charles had no equivalent to restore. Wolsey used every argument to induce the Emperor to withdraw his claim; but he was obstinate, and the conference came to an end. It is true that Wolsey tried to keep up appearances by concluding a truce for a month, that the Emperor might go to Spain and consult his subjects about the surrender of Fontarabia.

So Wolsey departed from Calais on 25th November, disappointed and worn out. As he wrote himself, "I have been so sore tempested in mind by the untowardness of the chancellors and orators on every side, putting so many difficulties and obstacles to condescend to any reasonable conditions of truce and abstinence of war, that night nor day I could have no quietness nor rest." There is no doubt that Wolsey wrote what he felt. He had laboured hard for peace, and had failed. If he hoped that the labours of the conference might still be continued by his diplomacy in England, that hope was destroyed before he reached London. On 1st December the imperial troops captured Tournai, which they had been for some time besieging, and news came from Italy that Milan also had fallen before the forces of the Emperor and the Pope. Charles had seemed to Wolsey unreasonable in his obstinacy. He had refused a truce which he had every motive of prudence for welcoming; and now events proved that he was justified. Not only had Francis been foiled in his attempts to embarrass his rival, but success had followed the first steps which Charles had taken to retaliate. The time for diplomacy was past, and the quarrel must be decided by the sword.

So Wolsey saw his great designs overthrown. He was a peace minister because he knew that England had nothing to gain from war. He had striven to keep the peace of Europe by means of England's mediation, and his efforts had been so far successful as to give England the first place in the counsels of Europe. But Wolsey hoped more from diplomacy than diplomacy could do. Advice and influence can do something to check the outbreak of war when war is not very seriously designed; but in proportion as great interests are concerned, attempts at mediation are useless unless they are backed by force. England was not prepared for war, and had no troops by whom she could pretend to enforce her counsels. When the two rival powers began to be in earnest, they admitted England's mediation only as a means of involving her in their quarrel. Wolsey was only the first of a long series of English ministers who have met with the same disappointment from the same reason. England in Wolsey's days had the same sort of interest in the affairs of the Continent as she has had ever since. Wolsey first taught her to develop that interest by pacific counsels, and so long as that has been possible, England has been powerful. But when a crisis comes England has ever been slow to recognise its inevitableness; and her habit of hoping against hope for peace has placed her in an undignified attitude for a time, has drawn upon her reproaches for duplicity, and has involved her in war against her will.

This was now the net result of Wolsey's endeavours, a result which he clearly perceived. His efforts of mediation at Calais had been entirely his own, and he could confide to no one his regret and his disappointment. Henry was resolved on war when Wolsey first set forth, and if Wolsey had succeeded in making a truce, the credit would have been entirely his own. He allowed Henry to think that the conference at Calais was merely a pretext to gain time for military preparations; if a truce had been made he would have put it down to the force of circumstances; as his efforts for a truce had failed, he could take credit that he had done all in his power to establish the king's reputation throughout Christendom, and had fixed the blame on those who would not follow his advice. It is a mark of Wolsey's conspicuous skill that he never forgot his actual position, and never was so entirely absorbed in his own plans as not to leave himself a ready means for retreat. His schemes had failed; but he could still take credit for having furthered other ends which were contrary to his own. Henry was well contented with the results of Wolsey's mission, and showed his satisfaction in the customary way of increasing Wolsey's revenues at the expense of the Church. The death was announced of the Abbot of St. Alban's, and the king, in answer to Wolsey's request, ordered the monks to take Wolsey for their abbot, saying, "My lord cardinal has sustained many charges in this his voyage, and hath expended £10,000." So kings were served, and so they recompensed their servants.