In London Gainsborough came into personal contact with Sir Joshua Reynolds, probably for the first time, although from a note of Walpole in his catalogue of the Royal Academy of 1773 it would appear that they had been in touch with one another some years previously, Walpole's words being: "Gainsborough and Dance, having disagreed with Sir Joshua Reynolds, did not send any pictures to this exhibition." When the Academy was founded in 1768 Gainsborough was one of the original members, and to the first four exhibitions he sent from Bath seventeen portraits and fifteen landscapes. Then for four years, no doubt on account of the disagreement mentioned by Walpole, he exhibited nothing until 1777, when his name reappears in the catalogue with portraits of the Duke and Duchess of Cumberland.

The vogue of Gainsborough was now at its height, and a long series of portraits of royal personages began to occupy his easel. It was one of these which, a few years later, led to his final quarrel with the Royal Academy. To the exhibition of 1783 he had sent eight portraits and portrait groups, including one of the three "Eldest Princesses." He sent the frames only in the first instance, but kept back that of the princesses, the king and queen having expressed a wish to view the picture before it was sent to the Academy. There was then a rule of the exhibition, one which is still in force, that full-length portraits could not be hung on the line, and by some misapprehension, it must have been thought by the hanging committee that this was a full-length group. Gainsborough must have heard of the place which had been assigned to it, and he sent the following curt note to Somerset House, where the Royal Academy exhibitions were then held:—

"Mr. Gainsborough presents his Compliments to the Gentlemen appointed to hang the pictures at the Royal Academy, and begs leave to hint to them that if the Royal Family, which he has sent for this Exhibition (being smaller than three-quarters), are hung above the line along with full-lengths, he never more, whilst he breathes, will send another Picture to the Exhibition.

This he swears by God.

Saturday morn."

This letter did not have the desired effect, so Gainsborough withdrew his pictures and never exhibited again. It would appear that such a quarrel, obviously the result of a misunderstanding, could easily have been adjusted by the President, had he felt inclined to interfere; but Sir Joshua evidently preferred to let matters take their course, and so the break became permanent.

There never was any great sympathy between the two men, although their mutual admiration for each other's work was considerable. Their characters were essentially different, and although they frequently shared the same sitters, and had some friends in common, they lived in a social atmosphere entirely distinct. On the other hand they never were enemies, nor had any serious personal quarrel; at one time it even seemed as though they might be drawn into friendship, and Gainsborough started painting the President's portrait; this, however, shared the fate of Thicknesse's years before and got no further than the first sitting. Their relations were such, however, that Gainsborough was able to call Reynolds to his death-bed, although they had probably had no intercourse for years. The pathetic story of Gainsborough's last illness is best told in the words of Allan Cunningham: "Though Gainsborough was not partial to the society of literary men, he seems to have been acquainted with Johnson and with Burke, and he lived on terms of great affection with Richard Brinsley Sheridan. He was also a welcome visitor at the table of Sir George Beaumont, a gentleman of graceful manners, who lived in old English dignity, and was, besides, a lover of literature and a painter of landscape. The latter loved to relate a curious anecdote of Gainsborough, which marks the unequal spirit of the man, and shows that he was the slave of wayward impulses which he could neither repress nor command. Sir George Beaumont, Sheridan, and Gainsborough had dined together, and the latter was more than usually pleasant and witty. The meeting was so much to their mutual satisfaction that they agreed to have another day's happiness, and accordingly an early day was named when they should dine again together. They met, but a cloud had descended upon the spirit of Gainsborough, and he sat silent with a look of fixed melancholy, which no wit could dissipate. At length he took Sheridan by the hand, led him out of the room, and said, "Now, don't laugh, but listen. I shall die soon—I know it—I feel it. I have less time to live than my looks infer; but for this I care not. What oppresses my mind is this: I have many acquaintances and few friends; and as I wish to have one worthy man to accompany me to the grave, I am desirous of bespeaking you. Will you come; aye or no?" Sheridan could scarcely repress a smile as he made the required promise; the looks of Gainsborough cleared up like the sunshine of one of his own landscapes; throughout the rest of the evening his wit flowed and his humour ran over, and the minutes, like those of the poet, winged their way with pleasure.

About a year after the promise obtained from Sheridan to attend his funeral he went to hear the impeachment of Warren Hastings, and, sitting with his back to an open window, suddenly felt something inconceivably cold touch his neck above the shirt collar. It was accompanied with stiffness and pain. On returning home he mentioned what he felt to his wife and his niece, and on looking they saw a mark about the size of a shilling, which was harder to the touch than the surrounding skin, and which he said still felt cold. The application of flannel did not remove it, and the artist becoming alarmed, consulted one after the other the most eminent surgeons of London—John Hunter himself the last. They all declared there was no danger; but there was that presentiment upon Gainsborough from which none perhaps escape. He laid his hand repeatedly on his neck and said to his sister, who had hastened to London to see him, "If this be a cancer, I am a dead man." And a cancer it proved to be. When this cruel disease fairly discovered itself, it was found to be inextricably interwoven with the threads of life, and he prepared himself for death with cheerfulness and perfect composure. He desired to be buried near his friend Kirby in Kew churchyard, and that his name only should be cut on his grave-stone. He sent for Reynolds, and peace was made between them. Gainsborough exclaimed to Sir Joshua: "We are all going to heaven, and Van Dyck is of the company," and immediately expired—August 2nd, 1788, in the sixty-first year of his age. Sheridan and the president attended him to the grave.