SEX IN TERMS OF INTERNAL SECRETIONS
Continuity of germplasm; The sex chromosome; The internal secretions and the sex complex; The male and the female type of body; How removal of sex glands affects body type; Sex determination; Share of egg and sperm in heredity; Nature of sex—sexual selection of little importance; The four main types of secretory systems; Sex and sex-instincts of rats modified by surgery; Dual basis for sex; Opposite-sex basis in every individual; The Free-Martin cattle; Partial reversal of sex in man.
In Chapter I, the "immortality" of the protoplasm in the germ cells of higher animals, as well as in simpler forms without distinct bodies, was mentioned. In these higher animals this protoplasm is known as germplasm, that in body cells as somatoplasm.
All that is really meant by "immortality" in a germplasm is continuity. That is, while an individual may consist of a colony of millions of cells, all of these spring from one cell and it a germ cell—the fertilized ovum. This first divides to form a new group of germ cells, which are within the embryo or new body when it begins to develop, and so on through indefinite generations. Thus the germ cells in an individual living to-day are the lineal descendants, by simple division, of the germ cells in his ancestors as many generations, or thousands of generations, ago as we care to imagine. All the complicated body specializations and sex phenomena may be regarded as super-imposed upon or grouped around this succession of germ cells, continuous by simple division.
The type of body in each generation depends upon this germplasm, but the germplasm is not supposed to be in any way modified by the body (except, of course, that severe enough accidents might damage it). Thus we resemble our parents only because the germplasm which directs our development is a split-off portion of the same continuous line of germ cells which directed their development, that of their fathers, and so on back. This now universally accepted theory is called the "continuity of the germplasm."
It will be seen at once that this seems to preclude any possibility of a child's inheriting from its parents anything which these did not themselves inherit. The bodies of each generation are, so to speak, mere "buds" from the continuous lines of germplasm. If we develop our muscles or our musical talent, this development is of the body and dies with it, though the physical basis or capacity we ourselves inherited is still in the germplasm and is therefore passed along to our children. We may also furnish our children an environment which will stimulate their desire and lend opportunity for similar or greater advancement than our own. This is social inheritance, or the product of environment—easy to confuse with that of heredity and very difficult to separate, especially in the case of mental traits.
It will likewise become clear as we proceed that there is no mechanism or relationship known to biology which could account for what is popularly termed "pre-natal influence." A developing embryo has its own circulation, so insulated from that of the mother that only a few of the most virulent and insidious disease germs can ever pass the barrier. The general health of the mother is of utmost importance to the vitality, chances of life, constitution and immunity from disease of the unborn child. Especially must she be free from diseases which may be communicated to the child either before or at the time of birth. This applies particularly to gonorrhoea, one of the most widely prevalent as well as most ancient of maladies, and syphilis, another disastrous and very common plague which is directly communicable. As to "birthmarks" and the like being directly caused by things the mother has seen or thought about, such beliefs seem to be founded on a few remarkable pure coincidences and a great deal of folk-lore.
Reproduction in its simplest form is, then, simply the division of one cell into two parts, each of which develops into a replica of the original. Division is also the first stage in reproduction in the most complicated animal bodies. To get an idea of what takes place in such a division we must remember that a cell consists of three distinct parts: (a) the protoplasm or cytoplasm, (b) the nucleus, and (c) a small body known as the centrosome which need not be discussed here.
When a cell division takes place, the nucleus breaks up into a number of thread-like portions which are known as chromosomes. There are supposed to be 24 pairs, or 48, in the human cell. All the evidence indicates that these chromosomes carry the "factors" in inheritance which produces the characters or characteristics of the individual body.
In mitosis or ordinary cell division, these chromosomes split lengthwise, so that the new cells always have the same number as the original one. When the germ-cells of the male and female make the division which marks the first step in reproduction, however, the process is different. Half the chromatin material passes into each of the two cells formed. This is called maturation, or the maturation division, and the new cells have only half the original number of chromosomes. Each of these divides again by mitosis (the chromosomes splitting lengthwise), the half or haploid number remaining. The result is the gametes (literally "marrying cells"—from the Greek gamé, signifying marriage). Those from the male are called sperms or spermatozoa and those from the female eggs or ova. (The divisions to form ova present certain complications which need not be taken up in detail here.) Of the 24 chromosomes in each sperm or egg we are here concerned with only one, known as the sex chromosome because, in addition to transmitting other characteristics, it determines the sex of the new individual.