The discomfort from blisters over the heart during the acute stage of endocarditis is greater than any good which they can do. In adults a few small blisters may be used intermittently around the borders of the heart, after the acute symptoms are over, to act reflexly on the heart and possibly aid absorption of inflammatory products. Sometimes improvement seems to follow such treatment; it certainly can do no harm.
During convalescence, the skin over the heart may be painted with iodin, repeated often enough to cause stimulation without injuring the skin; it seems at times to be of value. Various iodin or iodid ointments have been used, but they probably have no more value than the administration of small doses of iodid.
Systemic Treatment.—As this complication most frequently occurs during acute rheumatism, the question arises as to the value or harmfulness of salicylates and alkaline drugs. With our recent better understanding of the action on the heart of pure salicylates (either natural or synthetic saliclic acid, which have been shown to act identically, if equally pure), we must believe that in any ordinary dosage they will injure the heart but rarely. While salicylic acid will not prevent endocarditis, it should he continued, if it is of benefit with regard to the arthritis. The indication for its use depends on its effect on the joints. As it acts at times almost as a specific in rheumatism, it would seem that it should be of value in the endocarditis caused by rheumatism. On the other hand, the endocarditis occurs during the second or third week of acute rheumatism, after the blood has been thoroughly saturated with salicylic acid. Therefore it certainly does not tend to prevent rheumatic endocarditis; hence for this complication alone salicylic acid is not indicated.
ALKALIES
Anything which tends to increase the acidity of the tissues and to diminish the alkalinity of the blood, whether from starvation or outer causes, seems to pro-duce endocardial and myocardial irritation, if not actual inflammation. Therefore in a disease like rheumatism, which seems to be made worse by anything which increases the acidity, alkalies are obviously indicated, and it is probable that an increased alkalinity of the blood tends to prevent endocardial irritation, and may soothe an inflammation already present. Until we have some positive knowledge to the contrary, alkalies should be freely administered during endocarditis, especially during rheumatic endocarditis. Potassium citrate in 2 gm. (30 grain) closes, in wintergreen water, should be given every three to six hours, depending on how readily the urine is made alkaline. This may be given with the salicylic acid treatment, and also when the salicylic acid has been stopped. It may be well, if sodium salicylate is being used, to give also sodium bicarbonate, the sodium bicarbonate often preventing irritation of the stomach from the sodium salicylate, the dose being equal parts of the sodium salicylate and the sodium bicarbonate administered in plenty of water. If some other form of salicylic acid is preferred, novaspirin, which is methylene-citryl-salicylic acid and contains 62 percent of salicylic acid, is perhaps the least irritant to the stomach of the salicylic preparations. This drug is decomposed in the intestine into its component parts, salicylic acid and methylene-citric acid. If this drug is combined with sodium bicarbonate, the disintegration into its component parts would be likely to occur in the stomach.
IRON
It is essential for the welfare of the patient, especially after a long illness before the complication of endocarditis could occur, and in rheumatic fever, in which all meat and meat extractives have been kept from the diet, that small doses of iron should be administered daily. Not only the fever process, but also the salicylic acid tends to prevent the healthy normal growth of red corpuscles. and such patients suffering from rheumatism are often seriously anemic after the aente inflammation has ceased. The iron administered may be 5 drops of the tincture of the chlorid, in lemonade or orangeade, twice in twenty-four hours (and it should be remembered that lemon and orange burn to alkalies in the system and do not act as acids); or 0.1 gm. (1 1/2 grains) of reduced iron in capsule twice in twenty-four hours, or a 3 grain tablet of saccharated ferric oxid (Eisenzucker) twice in twenty-four hours.
OPIUM
As so many times repeated, real pain must be stopped, and morphin, either by the mouth or hypodermically, should be used to the point of stopping such pain. If the patient is a young child, codein sulphate or the deodorized tincture of opium may be used in the dose found sufficient, and either one will act satisfactorily. The dose given should be small but repeated sufficiently often to stop the pain. The dose necessary for the given individual will soon be learned, and that dose may be repeated at such intervals as the condition may require. Sometimes the hypnotic selected, if one is needed, will be sufficient to quiet the cardiac aches or pains.