| Proteolysis by trypsin, | [93] |
| Comparison of pepsin and trypsin, | [94] |
| Trypsin especially a peptone-forming ferment, | [95] |
| The primary products of trypsin-proteolysis, | [95] |
| Scheme of trypsin-digestion, showing the relationship of the products formed, | [96] |
| The fate of hemi-groups in trypsin-proteolysis, | [97] |
| The primary products of trypsin-digestion mainly antibodies, | [98] |
| Character and composition of antipeptones, | [99] |
| Antialbumid as a product of pancreatic digestion, | [100] |
| The peculiar action of trypsin in the formation of amido-acids, etc., | [101] |
| Formation of lysin and lysatin in pancreatic digestion, | [103] |
| The relationship of lysatin to urea, | [105] |
| Formation of tryptophan or proteinochromogen by trypsin, | [105] |
| Appearance of ammonia in trypsin-proteolysis, | [107] |
| Relationship between artificial pancreatic digestion and proteolysis in the living intestine, | [109] |
| Leucin and tyrosin products of the natural pancreatic digestion in the intestine, | [112] |
| The physiological significance of leucin and tyrosin, | [113] |
| Absorption of the main products of proteolysis, | [116] |
| Absorption of acid-albumin, alkali-albuminate, etc. | [117] |
| Absorption limited mainly to the intestine, very little absorption from the stomach, | [119] |
| The change which the primary products of proteolysis undergo in the process of absorption, | [120] |
| Peptones not present in the circulating blood, | [121] |
| The change which peptones and proteoses undergo by contact with the living mucous membrane of the small intestine, | [122] |
| Retrogression of peptones by contact with other living cells, etc., | [125] |
| Functional activity of leucocytes in absorption, | [128] |
| Digestive leucocytosis incited by nuclein, | [131] |
| Shore’s experiments on the ability of lymph-cells to assimilate either proteoses or peptones, | [133] |
| Lymph a true secretion from the blood-vessels, | [134] |
| Direct excitatory effect of peptones when present in the blood on the endothelial cells, | [136] |
| Selective activity of endothelial cells, | [137] |
DIGESTIVE PROTEOLYSIS
LECTURE I.
THE GENERAL NATURE OF PROTEOLYTIC ENZYMES AND OF PROTEIDS.
INTRODUCTORY.
In digestive proteolysis we have a branch of physiological study which of late years has made much progress. Chemistry has come to the aid of physiology and by the combined efforts of the two our knowledge of the digestive processes of the alimentary tract has been gradually broadened and deepened. That which at one time appeared simple has become complex, but increasing knowledge has brought not only recognition of existing complexity, but has enabled us, in part at least, to unravel it.
By digestive proteolysis is to be understood the transformation of the proteid food-stuffs into more or less soluble and diffusible products through the agency of the digestive juices, or more especially through the activity of the so-called proteolytic ferments or enzymes contained therein; changes which plainly have for their object a readier and more complete utilization of the proteid foods by the system.