The marriage contract shows that by this time Vannozza had removed her residence to Piazza Branchis. In addition to this she had by this time acquired a villa with its beautiful gardens and vine­yards in the Suburra near S. Pietro in Vincoli. She is also known to have been the proprietor of an inn—the Albergo del Leone—in Via del Orso, opposite the Torre di Nona, for she figures with della Croce in a contract regarding a lease of it in 1483.

With her entrance into second nuptials, her relations with Cardinal Roderigo came to an end, and his two children by her, then in Rome—Lucrezia and Giuffredo—went to take up their residence with Adriana Orsini (née de Mila) at the Orsini Palace on Monte Giordano. She was a cousin of Roderigo’s, and the widow of Lodovico Orsini, by whom she had a son, Orso Orsini, who from early youth had been betrothed to Giulia Farnese, the daughter of a patrician family, still comparatively obscure, but destined through this very girl to rise to conspicuous eminence.

For her surpassing beauty this Giulia Farnese has been surnamed La Bella—and as Giulia La Bella was she known in her day—and she has been immortalized by Pinturicchio and Guglielmo della Porta. She sat to the former as a model for his Madonna in the Borgia Tower of the Vatican, and to the latter for the statue of Truth which adorns the tomb of her brother Alessandro Farnese, who became Pope Paul III.

Here in Adriana Orsini’s house, where his daughter Lucrezia was being educated, Cardinal Roderigo, now at the mature age of some six-and-fifty years, made the acquaintance and became enamoured of this beautiful golden-headed Giulia, some forty years his junior. To the fact that she presently became his mistress—somewhere about the same time that she became Orso Orsini’s wife—is due the sudden rise of the House of Farnese. This began with her handsome, dissolute brother Alessandro’s elevation to the purple by her lover, and grew to vast proportions during his subsequent and eminently scandalous occupation of the Papal Throne as Paul III.

In the year 1490 Lucrezia was the only one of Roderigo’s children by Vannozza who remained in Rome.

Giovanni Borgia was in Spain, whither he had gone on the death of his brother Pedro Luis, to take posession of the Duchy of Gandia, which the power of his father’s wealth and vast influence at the Valencian Court had obtained for that same Pedro Luis. To this Giovanni now succeeded.

Cesare Borgia—now aged fifteen—had for some two years been studying his humanities in an atmosphere of Latinity at the Sapienza of Perugia. There, if we are to believe the praises of him uttered by Pompilio, he was already revealing his unusual talents and a precocious wit. In the preface of the Syllabica on the art of Prosody dedicated to him by Pompilio, the latter hails him as the hope and ornament of the Hous of Borgia—“Borgiae familiae spes et decus.”

From Perugia he was moved in 1491 to the famous University of Pisa, a college frequented by the best of Italy. For preceptor he had Giovanni Vera of Arcilla, a Spanish gentleman who was later created a cardinal by Cesare’s father. There in Pisa Cesare maintained an establishment of a magnificence in keeping with his father’s rank and with the example set him by that same father.

It was Cardinal Roderigo’s wish that Cesare should follow an ecclesiastical career; and the studies of canon law which he pursued under Filippo Decis, the most rated lecturer on canon law of his day, were such as peculiarly to fit him for that end and for the highest honours the Church might have to bestow upon him later. At the age of seventeen, while still at Pisa, he was appointed prothonotary of the Church and preconized Bishop of Pampeluna.

Sixtus IV died, as we have seen, in August 1482. The death of a Pope was almost invariably the signal for disturbances in Rome, and they certainly were not wanting on this occasion. The Riario palaces were stormed and looted, and Girolamo Riario—the Pope’s “nepot”—threw himself into the castle of Sant’ Angelo with his forces.