1719
1726
The regiment was stationed in Ireland during the eight years from 1719 to 1726, and in the spring of the last-mentioned year, it proceeded to the island of Minorca, which had been captured by the English, in 1708, and was ceded to Great Britain by the treaty of Utrecht in 1713, together with the fortress of Gibraltar.
1727
In the beginning of 1727, the Spaniards besieged Gibraltar, and a detachment of the regiment, being sent to reinforce the garrison, had the honor to take part in the successful defence of that important fortress. When the Spaniards raised the siege, the detachment rejoined the regiment at Minorca.
1730
Colonel Handasyd commanded the regiment with reputation until 1730, when he was removed to the Sixteenth foot, and was succeeded by Brigadier-General William Barrell, from the Twenty-eighth regiment.
1734
Brigadier-General Barrell was removed to the Fourth foot in 1734, when King George II. conferred the colonelcy of the TWENTY-SECOND regiment on Colonel the Honorable James St. Clair, from Major in the First foot-guards.
1737
On the 27th of June, 1737, Colonel the Honorable James St. Clair was removed to the First, the Royal regiment of foot, and his Majesty nominated Major-General John Moyle, from the Thirty-sixth, to the colonelcy of the TWENTY-SECOND regiment.