1. I find, that if a piece of zinc be applied to the tongue, and be in contact with a piece of silver, which touches any part of the lining of the mouth, nostrils, ear, urethra, or anus, the sensation resembling taste is felt on the tongue. If the experiment be inverted, by applying the silver to the tongue, the irritation produced by the zinc is not sensible, except in the mouth and the urethra, and is very slight. I find the irritation by the zinc strongest when the contact is very slight, and confined to a narrow space, and when the contact of the silver is very extensive, as when the tongue is applied to the cavity of a silver spoon. When the zinc touches in an extensive surface, the irritation produced by a narrow contact of the silver is very distinct, especially on the upper side of the tongue, and along its margin. This irritation seems to be mere pungency, without any resemblance to taste, and it leaves a lasting impression, like that made by caustic alcali.

2. If the zinc (finely polished) be applied to the ball of the eye, the brightness of the flash seems to correspond with the surface of contact, of the silver with the tongue, palate, fauces or cheek. The same thing happens when the silver is applied to the eye.

3. When a rod of zinc, and one of silver are applied to the roof of the mouth, as far back as possible, the irritations produced, by bringing their outer ends into contact, are very strong, and that by the zinc resembles taste, in the same manner as when applied to the tongue.

4. I had been paring my toe nails with scizzars, and had cut off a considerable portion of the thick skin, so that the blood began to ooze through, in the middle of the wound. I applied the zinc there, and an extensive surface of silver to the tongue. Every time I brought the metals into contact, I felt a very smart irritation by the zinc at the wound.

5. I made a piece of zinc having a sharp point, projecting laterally from its end. I applied this point to a hole in a tooth, which has sometimes ached a little, and applied the silver in an extensive surface to the inside of the cheek. When the metals were brought into contact, I felt a very smart and painful twitch in the tooth, perfectly resembling a twitch of the toothack. I thought this twitch double, and that one of them happened before the metals came into absolute contact. I am now almost convinced, that this is the case, for when I make the silver rest on a dry tooth, without touching the tongue or fauces, I have no twitch on bringing the outer ends of the metals together: showing that there is not a proper communication through a dry tooth. If, while the outer ends remain in contact, I touch the silver with the tip of the tongue, still no twitch is felt in the tooth. If I now separate the outer ends of the metals, keeping the tongue applied to the silver, a slight twitch is felt in the moment of separation, and a strong double twitch when they are again brought into contact. N. B. This twitch is prevented, by allowing the tongue or lip to touch any part of the zinc.

6. I had a number of pieces of zinc made of the size of a shilling, and made them up into a rouleau, with as many shillings. I find that this alternation, in some circumstances, increases considerably the irritation, and expect, on some such principle, to produce a still greater increase. If the side of the rouleau be applied to the tongue, so that all the pieces are touched by it, the irritation is very strong and disagreeable. This explains what I have often observed, the strong taste of soldered seams of metal. I can now perceive seams in brass and copper vessels by the tongue, which the eye cannot discover, and can distinguish the base mixtures which abound in gold and silver trinkets.

If any of the above facts can add to the stock of knowledge you have acquired on this subject, it will give me great satisfaction, and I shall not fail to communicate any thing which may afterwards occur. My indisposition hinders me from taking an active part in the researches, to which this wonderful and important discovery incites; but it is both my duty and my earnest wish, to contribute my feeble assistance to every gentleman engaged in this interesting pursuit.

I find that common silver thread makes a very good conductor, and this to any distance.

Since writing the above, I have found a very easy way of producing very sensible convulsions, (I think muscular) and corroborating my opinion, that the communication (of this part of the whole effect) takes place before contact.

Put a plate of zinc into one cheek, and a plate of silver, (a crown piece) into the other, at a little distance from each. Apply the cheeks to them as extensively as possible. Thrust in a rod of zinc between the zinc and the cheek, and a rod of silver between the silver and the other cheek. Bring their outer ends slowly into contact, and a smart convulsive twitch will be felt in the parts of the gums situated between them, accompanied by bright flashes in the eyes. And these will be distinctly perceived before contact, and a second time on separating the ends of the rods, or when they have again attained what may be called the striking distance. If the rods be alternated, no effect whatever is produced.