More difficult and terrifying are the Symptoms from the Bite of a Mad Dog, whose Venom has this also surprising in it, that the bad Effects do not appear oftentimes till the Cause of ’em is forgot; for the Wound is as easily cured as a common Bite is; but nevertheless a considerable time after, a melancholy Tragedy succeeds, sometimes sooner, sometimes later; for there are Instances of its being deferred to Two, [(70)] Six Months, nay, a Year, and longer, tho’ the attack is generally within Forty Days after the Wound; about that time, the Patient complains of Running Pains all over his Body, especially near the Part wounded, like unto those in a Rheumatism, grows pensive and sad, prone to Anger upon little or no Occasion, with an intermitting Pulse, Tremblings and Contractions of the Nerves, with a great inward Heat and Thirst; and yet in a few Days (when the Disease is come to its height) a Dread and Fear of Water, and any Liquor whatsoever; so that at the very sight of it he falls into dismal Convulsions and Agonies, and cannot drink the least drop; and this Hydrophobia, or Aquæ Timor, has been always accounted the surest Sign and Mark of this Poison, as distinguishing it from all others.

The Ancients have at large described these Symptoms, as Galen, Dioscorides, Aetius, Ægineta, but most particularly of all, Cælius Aurelianus [(71)]; and later Writers have given us several Instances of the Hydrophobia; Two Histories of it published, the one by Dr. Lister [(72)], the other by Dr. Howman [(73)], I shall more especially take Notice of, and refer to, as containing the most exact and large Account of any I have met with; he that desires more, may consult the several Authors cited by that diligent Observer, Stalpart van der Wiel [(74)].

That this Disease is accompany’d with a Delirium, is almost the common Opinion both of Ancients and Moderns; Damocrates called it the barking Phrensie [(75)]; but Dr. Lister agrees in this Point with Petrus Salius Diversus [(76)], and will not allow a Delirium to be the necessary consequent of this Venom; and yet at the same time he tells us, that his Patient barked like a Dog, and bit at the By-standers; that he threw into his Mouth what was given him more hastily and suddenly than it is Natural or Customary for Men to do.

From such Actions as these, together with those mentioned before in relating the Symptoms, it is obvious enough to conclude, that Persons thus affected are in a proper Sence Delirous. Tho’ at the same time I do think that the Hydrophobia it self (whatever is commonly believed) does not at all proceed from this Delirium, as will by and by appear.

I know indeed that the main and plausible Objection against a Delirium is this, that the Patient himself does Reason against his Timorousness, tho’ he cannot overcome it, forewarns the Standers-by of his Outrageous Fits, desires them to take care of themselves, and the like. Which from what I have already said concerning a Delirium, appears to be very consistent with it, nay, convinces that there is the greatest Degree of it in this Case; in as much as that it is not a Distemper of the Mind but of the Body. And to this purpose I remember to have seen my self an Instance of one in a Fever, who foretold some time before any signs of a Delirium were discovered, how raving and unruly He should be, and made good his Prognostick to that degree, that it was very hard Work to tame and master him; tho’, as he told me afterwards, he reason’d as much as he could against that groundless Jealousie of his Friends designing to Murder him, which put him upon his Mad Actions, but was not able to Conquer the prevailing Species of Fear and Anger.

This Delirium therefore, as Cælius Aurelianus [(77)] says, Proceeds intirely from an indisposition of the Body, which is without all doubt owing to the alteration made in the Blood by the Saliva of the Mad Dog, instill’d into the Wound inflicted by the Bite.

That we may rightly understand this, we must take Notice, that the Rabies or Madness in a Dog is the effect of a Violent Fever; and therefore it is most common in excessive Hot Weather, tho’ sometimes intense Cold maybe the Cause of it; That no Dog in this Case ever sweats; from whence it follows, that when his Blood is in a Ferment, it cannot, as in other Creatures, discharge it self upon the surface of the Body, and therefore must of necessity throw out a great many Saline and Active Particles upon those Parts, where there is the most constant and easie Secretion; and such, next to the Miliary in the Skin in Us, are the Salival Glands; for this reason much more Spittle is separated in a Dog when Mad, than at any other time, and that very frothy, or impregnated with Hot, Subtil Parts.

Now as we every Day observe, that what is thrown out from Liquors in a Ferment, is capable of inducing the like Motion in another Liquor of the same kind, when duly mixed with it; so we may very well suppose in the present Case, that the Saliva, which is it self one of the most Fermentative Juices in Nature, being turgid with Fiery, Saline Particles thrown into it out of the boiling Blood, when it comes by means of a Wound to be Incorporated with the Arterial Fluid of any One, does by Degrees raise a preternatural Effervescence in it; the Effects of which will necessarily be most felt in those Parts which being tender, are the least able to refill the distension of the Blood Vessels; such are the Stomach, and especially the Brain; and hereupon Deliria, with Maniacal, and such like Symptoms, will easily insue.

A Person thus affected may be said in a Degree to have put on the Canine Nature, tho’ his Reason be all this time untouch’d and intire, may Bite, Howl, &c. because the like violent Agitation of the Blood in Him as was in the Dog will present like Species, and consequently (so far as their different Natures will allow) produce like Actions; just as it has been observed, that Sheep bitten by a Mad Dog, have run at the Shepherd like so many Dogs to Bite him; so much can an Alteration of the Blood and Spirits do. And as a Timorous Creature may be imboldened, so we oftentimes see Persons Courageous enough by a change made in the Blood by Evacuations, that is, by want of Force and Motion in that Fluid, made sheepish Cowards, in despight of their Reason, so long as that Defect is continued.

But the main difficulties in this matter are, the Mischief discovering it self so long after the Bite, and the Hydrophobia.