Tuberculosis may affect the ovaries and cause permanent sterility. In inflammation of the lining membrane of the womb and vagina, the secretions are abnormal and may collect in the womb and the passages leading to it. These secretions destroy the vitality of the spermatozoa, and this condition may be considered a common cause of sterility in the larger animals. Many vigorous young males are made impotent by excessive copulation. The excessive use of the male at any time may result in failure to impregnate a large percentage of the females that he serves.

Barren females do not become pregnant after frequent intercourse with the male. Young sterile females may not come in heat. Sometimes unnatural periods of heat are manifested, the animal coming in heat frequently or remaining in heat for a longer period than usual. This sometimes occurs in tuberculosis of the ovaries. In chronic inflammation of the maternal passage there is more or less discharge from the vulva. Both sexes may be overly fat or weakened and debilitated by disease. Deformity of the generative organs and growths may be found on making an examination. Absence of, or lack of vitality of the spermatozoa may be determined by microscopic examination of the seminal fluid.

The treatment is largely preventive. It is very important that breeding animals be kept in proper physical condition by avoiding the feeding of too heavy or too light a ration, and allowing them sufficient exercise. The male is more often affected by the latter cause than the female. This is because the average stockman does not consider exercise given under the right conditions an important factor in maintaining the vigor of the male. Young males should not be given excessive intercourse with the female. Such practice is certain to seriously affect the potency of the animal. The excessive use of the stallion can be avoided by practising artificial impregnation of a part of the mares that he is called to serve. Sterility caused by growths and closure of the os may be corrected by an operation.

Chronic inflammation of the maternal passages should be treated by irrigating the parts with a one per cent warm water solution of lysol, or liquor cresolis compound. The parts should be irrigated daily for as long a period as necessary. Fat animals should be subjected to a rigid diet and given plenty of exercise. Following this treatment a stimulating ration may be fed for the purpose of encouraging the sexual desire. In weak and debilitated animals, the cause should first be removed and a proper ration fed. Cantharides and strychnine are the drugs most highly recommended for increasing the sexual desire.

SIGNS OF PREGNANCY.—The signs which characterize pregnancy are numerous and varied. For convenience we may classify the many signs of pregnancy under two heads, probable and positive. Under the head of probable signs, we may group the following symptoms of pregnancy: cessation of heat; changes in the animal's disposition; increase in the volume of the abdomen and tendency to put on fat. The positive signs are the change in the volume of the udder; the secretion of milk; the movement of the foetus and presence of the foetus in the womb, as determined by rectal examination or by the feel of the abdomen.

The probable signs are not reliable, and should be considered only in connection with some positive sign. Persons who base their opinion of the condition of an animal that is supposed to be pregnant on probable signs, are frequently mistaken. It has frequently happened that animals whose condition was not at all certain have given birth to young, without giving rise to what may be termed characteristic probable signs.

The earliest probable symptom is the cessation of heat. In the large pregnant animals, irregular heat periods may occur, but in the majority of cases we may safely consider the animal impregnated if several heat periods are passed over.

It has been generally observed that the disposition of the pregnant animal is changed. They become more quiet and less nervous and irritable. The tendency of pregnant animals to put on fat is frequently taken advantage of by the stockman, who may allow the boar to run with the herd during the latter period of fattening.

The increase in the volume of the abdomen may be considered a positive sign of pregnancy in the small animals, but in the mare and cow it can not be depended on. Animals that are pregnant for the first time, do not show as great an increase in the volume of the abdomen as do animals that have gone through successive pregnant periods. The volume of the abdomen may vary greatly in the different individuals, and can not be depended on as a positive indication of pregnancy during the first two-thirds of the period of pregnancy in the larger domestic animals.

Comparatively early in pregnancy, the presence of a foetus can be determined by feeling the uterus through the wall of the rectum. In the small domestic animals the feeling of the abdomen gives the best results. In the cow this method of diagnosis is practised during the latter periods of pregnancy. The examiner stands with his back toward the animal's head, and on the right side of the cow and the left side of the mare. The palm of the hand is applied against the abdominal wall, about eight or ten inches in front of the stifle and just below the flank. Moderate pressure is used, and if a hard, voluminous mass is felt, or if the foetus moves, it is a sure sign that the animal is pregnant. It is not uncommon for the foetus to show some movement in the morning, or after the animal drinks freely of cold water. The increase in the volume of the udder occurs at a comparatively early period in animals that are pregnant for the first time. The secretion of milk and the dropping of the muscles of the quarters indicate that parturition is near. The Abderhalden test for determining whether or not an animal is pregnant is now practised.