Treatment.—The means of preventing inflammatory action from running high and ending in death of bone have been already alluded to—abstraction of blood, rest, purgatives, and antimonials. When necrosis has occurred, no interference with the bone is allowable, unless the sequestrum is quite loose, or unless the patient’s health is suffering severely under the discharge and irritation. When the sequestrum can be readily moved about, or when, projecting through the external opening, it can be laid hold of by the fingers or forceps, attempts must be made to remove it. The surgeon ought not, however, to allow it to approach the surface, and project externally, for the natural discharge of the sequestrum is a much more tedious process than the removal of it by art, and by the irritation produced during its spontaneous ejection the inflammatory action is continued, and may prove alarming. Long before it has appeared externally, it must have been completely separated from the living parts, so as to admit of ready extraction by the proper means. When it has been ascertained that the sequestrum is separated, it ought to be laid hold of by forceps, and moved freely upward and downward, so that any slight attachments by which it is connected to the neighbouring parts may be destroyed, whether these be minute filaments which still in some degree retain their vitality, or small portions of newly deposited bone, which are so situated as to prevent the free movement of the sequestrum. In general, no impediment of this nature exists, and the dead bone is easily removed. Before extraction can be accomplished, it is generally necessary to enlarge freely the external opening, in all cases where the dead portion of bone is of considerable size. If, on thus exposing the parts, the sequestrum be found detached, but still firmly bound down by the substitute bone, deposited over it either in one continuous sheet, or in irregular columns, this must be divided by a trephine, a small saw, or cutting pliers, before the sequestrum can be extracted. When a dead portion of bone, of considerable length, is exposed at its centre, whilst its extremities are entangled by the old or substitute bone, the division of the exposed part of sequestrum, by means of the cutting pliers, will often be sufficient for its removal, the cut ends being seized by the forceps, and one half removed after the other; thus the perforation or removal of any portion of the substitute will be rendered unnecessary. The instruments, and especially those for extraction, ought to be very powerful, and suited to the purpose; for in the employment of inefficient means there is much folly and cruelty. Incisions into a necrosed limb are attended with profuse hemorrhage from the enlarged and excited vessels; and in some cases it is with difficulty arrested, in consequence of retraction of the cut ends of the vessels not taking place within the condensed and indurated parts. Pressure, and an elevated position of the part, will generally be found to answer. When necrosis has been extensive, the limb must be carefully supported by the application of splints and bandage, till the process of reparation be completed, in order to prevent fracture of the recently formed substitute. This proceeding is seldom, however, necessary.

The treatment may be summed up in a very few words. Prevent the necrosis, if possible; open abscesses whenever they appear; encourage the patient to move the neighbouring joints; support the strength; remove sequestra when loose, but do not interfere till they are ascertained to be so; give the limb proper support and rest, when a large sequestrum is formed. When fracture has taken place, when the

health has been undermined, or when neighbouring joints have become diseased, amputate, in order to save the life, if it be impossible to save the limb.

It is almost superfluous to remark, that leeching and blistering are worse than useless after necrosis has occurred, however useful they may be in preventing it; and that the adoption of measures to promote the dissolution and absorption of the sequestra are glaringly absurd.

Necrosis, after amputation, was formerly frequent; but in the present improved state of this operation it is so rare as scarcely to demand separate consideration.

Such specimens as here depicted are common enough in the collections of those who have practised the old round-about operation; in fact, it is only by this painful and tedious interference of nature that a tolerable stump is formed in many of these cases. Death of a small portion will sometimes, though very rarely, follow even a very well

performed amputation, if through any mischance the recovery is slow, and wasting discharge takes place with emaciation. It happens sometimes, as when secondary hemorrhage (that is to say, bleeding after the fourth day) has taken place, that the flaps are separated by the coagula, and it may be impossible to bring the parts together and give them due support; then the muscles, wasted and shrunk, may leave the bone a little, but the exfoliation is but very trifling.

The inner shell of bone, as may be seen in the above sketch, perishes more extensively than the outer; and this arises probably from inflammation of the medullary membrane, in consequence of exposure, or, perhaps, from its being sometimes injured by the operator or assistants seizing the bone rudely to steady the stump, in order to facilitate the ligature of the vessels. In experiments on animals, the disturbance and injury of the medullary membrane is followed by internal necrosis, thickening of the outer living shell, and effusion betwixt the periosteum and bone. New bone is also furnished from the medullary canal, as is also shown in the sketch.