All the agents of which we have spoken, with the exception of tobacco, whose action from the first is decidedly sedative, operate partly by stimulating the frame. They cause the heart to throb more vigorously, and the blood to circulate freer, while, at the same time, they exert a peculiar action upon the nervous system. The nature of this action, it is probable, will never be satisfactorily explained. If mere stimulation were all that was wanted, drunkenness ought to be present in many cases where it is never met with. It, or more properly speaking, its symptoms, ought to exist in inflammatory fever, and after violent exercise, such as running or hard walking. Inebriating agents, therefore, with few exceptions, have a twofold action. They both act by increasing the circulation, and by influencing the nerves; and the latter operation, there can be no doubt, is the more important of the two. Having stated this general fact, it will be better to consider the cause of each individual symptom in detail.

I. Vertigo.—This is partly produced by the ocular delusions under which the drunkard labours, but it is principally owing to other causes; as it is actually greater when the eyes are shut than when they are open—these causes, by the exclusion of light, being unaccountably increased. Vertigo, from intoxication, is far less liable to produce sickness and vomiting than from any other cause; and when it does produce them, it is to a very inconsiderable degree. These symptoms, in ninety-nine cases out of a hundred, arise from the disordered state of the stomach, and not, as we have elsewhere mentioned, from the accompanying giddiness. There are, indeed, a certain class of subjects who vomit and become pale, as soon as vertigo comes over them, but such are few in number compared with those whose stomachs are unaffected by this sensation. In swinging, smoking, sailing at sea, on turning rapidly round, sickness and vomiting are apt to occur; and there seems no doubt that they proceed in a great measure from the vertigo brought on by these actions. The giddiness of drunkenness, therefore, as it very rarely sickens, must be presumed to have some characters peculiar to itself. In this, as well as in some other affections, it seems to be the consequence of a close sympathy between the brain and nerves of the stomach; and whatever affects the latter organ, or any other viscus strongly sympathizing with it, may bring it on equally with inebriating agents: calculi in the uterus or biliary ducts are illustrations of this fact. In intoxication, the giddiness is more strongly marked, because the powers both of body and mind are temporarily impaired, and the sensorium so disordered as to be unable to regulate the conduct.

A degree of vertigo may be produced by loading the stomach too rapidly and copiously after a long fast. Common food, in this instance, amounts to a strong stimulus in consequence of the state of the stomach, in which there was an unnatural want of excitement. This organ was in a state of torpor; and a stimulus which, in ordinary circumstances, would hardly have been felt, proves, in reality, highly exciting. For the same reason, objects have an unnatural luminousness when a person is suddenly brought from intense darkness to a brilliant light.

II. Double Vision.—The double vision which occurs in drunkenness may be readily accounted for by the influence of increased circulation in the brain upon the nerves of sight. In frenzy, and various fevers, the same phenomenon occurs. Every nerve is supplied with vessels; and it is conceivable that any unusual impulse of blood into the optics may so far affect that pair as to derange their actions. Whence, they convey false impressions to the brain, which is itself too much thrown off its just equilibrium to remedy, even if that under any circumstances were possible, the distorted images of the retina. The refraction of light in the tears, which are secreted more copiously than usual during intoxication, may also assist in multiplying objects to the eye.

III. Staggering and Stammering.—These symptoms are, in like manner, to be explained from the disordered state of the brain and nervous system. When the organ of sensation is affected, it is impossible that parts whose actions depend upon it can perform their functions well. The nervous fluid is probably carried to the muscles in a broken and irregular current, and the filaments which are scattered over the body are themselves directly stunned and paralyzed; hence, the insensibility to pain, and other external impressions. This insensibility extends everywhere, even to the organs of deglutition and speech. The utterance is thick and indistinct, indicating a loss of power in the lingual nerves which give action to the tongue; and the same want of energy seems to prevail in the gustatory branches which give it taste.

IV. Heat and Flushing.—These result from the strong determination of blood to the surface of the body. This reddens and tumefies the face and eyes, and excites an universal glow of heat. Blood is the cause of animal heat, and the more it is determined to any part, the greater is the quantity of caloric evolved therefrom.

V. Ringing in the Ears.—This is accounted for by the generally increased action within the head, and more particularly by the throbbing of the internal carotid arteries which run in the immediate neighbourhood of the ears.

VI. Elevation of Spirits.—The mental pleasure of intoxication is not easily explained on physiological principles. We feel a delight in being rocked gently, in swinging on a chair, or in being tickled. These undoubtedly act upon the nerves, but in what manner, it would be idle to attempt investigating. Intoxicating agents no doubt do the same thing. The mental manifestations produced by their influence depend almost entirely upon the nerves, and are, unlike the corporeal ones, in a great measure independent of vascular excitement. The power of exciting the feelings inherent in these principles, can only be accounted for by supposing a most intimate relation to subsist between the body and the mind. The brain, through the medium of its nervous branches, is the source of all this excitement. These branches receive the impressions and convey them to their fountain-head, whence they are showered like sparkling rain-drops over the mind, in a thousand fantastic varieties. No bodily affection ever influences the mind but through the remote or proximate agency of this organ. It sits enthroned in the citadel of thought, and, though material itself, acts with wizard power both upon matter and spirit. No other texture has the same pervading principle. If the lungs be diseased, we have expectoration and cough; if the liver, jaundice or dropsy; if the stomach, indigestion; but when the brain is affected, we have not merely many bodily symptoms, but severe affections of the mind; nor are such affections ever produced by any organ but through the agency of the brain. It, therefore, acts in a double capacity upon the frame, being both the source of the corporeal feelings, and of the mental manifestations. Admitting this truth, there can be little difficulty in apprehending why intoxication produces so powerful a mental influence. This must proceed from a resistless impulse being given to the brain, by virtue of the peculiar action of inebriating agents upon the nerves. That organ of the mind is suddenly endowed with increased energy. Not only does the blood circulate through it more rapidly, but an action, sui generis, is given to its whole substance. Mere increase of circulation, as we have already stated, is not sufficient: there must be some other principle at work upon its texture; and it is this principle, whatever it may be, which is the main cause of drunkenness. At first, ebriety has a soothing effect, and falls over the spirit like the hum of bees, or the distant murmur of a cascade. Then to these soft dreams of Elysium succeed a state of maddening energy and excitement in the brain. The thoughts which emanate from its prolific tabernacle, are more fervid and original than ever—they rush out with augmented copiousness, and sparkle over the understanding like the aurora borealis, or the eccentric scintillations of light upon a summer cloud. In a word, the organ is excited to a high, but not a diseased action, for this is coupled with pain, and, instead of pleasurable, produces afflicting ideas. But its energies, like those of any other part, are apt to be over-excited. When this takes place, the balance is broken; the mind gets tumultuous and disordered, and the ideas inconsistent, wavering, and absurd. Then come the torpor and exhaustion subsequent on such excessive stimulus. The person falls into drowsiness or stupor, and his mind, as well as his body, is followed by languor corresponding to the previous excitation.

Such is a slight and unsatisfactory attempt to elucidate some of the more prominent phenomena of drunkenness. Some are omitted as being too obvious to require explanation, and others have been elsewhere cursorily accounted for in different parts of the work.