Harvey then noted a well-known clinical fact, that the more frequent or forcible the pulsations, the more speedily might the body be deprived of its blood during hemorrhage, and that it thus happens that in fainting fits and the like, when the heart beats more languidly, hemorrhages are diminished and arrested. The balance of the book is practically devoted to further demonstration and corroboration of statements already made. A study of this work of Harvey's illustrates how much respect even he and his contemporaries still showed for the authority of Galen. It shows still further how nearly Galen came to the actual truth concerning the circulation. Had the latter not adopted too many of the notions of his predecessors concerning the nature of the soul (Anima) and the spirits (Pneuma) of man, he might himself have anticipated Harvey by a thousand years, and by such announcement of a great truth have set forward physiology by an equal period. Independent and original as Harvey showed himself, he seems to have failed to get away from the notion of the vapors and spiritual nature of the blood which he had inherited from the writings of Galen and many others. Nevertheless he also alludes to this same blood as alimentive and nutritive. We must not forget, however, that this was years before Priestly's discovery of oxygen and that Harvey had, like others, no notion of the actual purpose of the lungs, believing that the purification and revivification of the blood was the office of the heart itself.
Along with its other intrinsic merits Harvey's book possesses a clear and logical arrangement, the author first disposing of the errors of antiquity, describing next the behavior of the heart in the living animal, showing its automatic pumplike structure, its alternate contractions and the other phenomena already alluded to, thus piling up facts one upon another in a manner which proved quite irresistible. The only thing that he missed was the ultimate connection between the veins and the arteries, i. e., the capillaries, which it remained for Malpighi to discover with the then new and novel microscope, which he did about 1657, showing the movement of the blood cells in the small vessels, and confirming the reality of that ultimate communication which had been held to exist. Malpighi discovered the blood corpuscles in 1665, but it remained for Leeuwenhoek, of Delft, in 1690, by using an improved instrument to demonstrate to all observers the actual movements of the circulating blood in the living animal. One historian has said that with Harvey's overthrow of the old teachings regarding the importance of the liver and of the spirits in the heart "fell the four fundamental humors and qualities" while Daremberg exclaims: "As in one of the days of the creation, chaos disappeared and light was separated from darkness."
It remains now only to briefly consider how Harvey's great discovery was received. To quote the words of one writer: "So much care and circumspection in search for truth, so much modesty and firmness in its demonstration, so much clearness and method in the development of his ideas, should have prepossessed everyone in favor of the theory of Harvey; on the contrary, it caused a general stupefaction in the medical world and gave rise to great opposition."
During the quarter of a century which elapsed after Harvey's announcement there probably was not an anatomist nor physiologist of any prominence who did not take active part in the controversy engendered by it; even the philosopher Descartes was one of the first adherents of the doctrine of the circulation, which he corroborated by experiments of his own.
Two years after the appearance of Harvey's book appeared an attack, composed in fourteen days by one Primerose, a man of Scotch descent, born and educated in France, but practising at Hull, in which he pronounced the impossibilities of surpassing the ancients or improving on the work of Riolan, who already had written in opposition to Harvey, and who was the only one to whom the latter vouchsafed an answer. It was Riolan who procured a decree of the Faculty of Paris prohibiting the teaching of Harvey's doctrine. It was this same Riolan who combated with equal violence and obstinacy the other great discovery of the age, namely,—the circulation of the lymph.
One of the earliest and fiercest adversaries of Harvey's theory was Plempius, of Louvaine, who, however, gave way to the force of argument and who finally publicly and voluntarily passed over to the ranks of its defenders in 1652, becoming one of Harvey's most enthusiastic advocates.
Harvey's conduct through the controversy was always of the most dignified character; in fact, he rarely ventured to reply in any way to his adversaries, believing in the ultimate triumph of the truths which he had enunciated. His only noteworthy reply was one addressed to Riolan, then Professor in the Paris Faculty and one of the greatest anatomists of his age, to whose opinion great value was always attached. Even in debating or arguing against him, Harvey always spoke of him with great deference, calling him repeatedly The Prince of Science. Riolan was, however, never converted, though whether he held to his previous position from obstinacy, from excess of respect for the ancients, or from envy and jealousy of his contemporary, is not known.
Another peculiar spectacle was afforded by one Parisunus, who died in 1643, a physician in Venice, who, like Harvey, had been a pupil of Fabricius of Aquapendente, who had been stigmatized by Riolan as an ignoramus in anatomy, but who joined with others in declaring that he had seen the heart beat when perfectly bloodless, and that no beating of the heart and no sounds were to be heard as Harvey had affirmed.
With the later and more minute studies into the structure and function of the heart we are not here concerned. The endeavor has been rather to place before you the sentiments, the knowledge and the habits of thought of the men of Harvey's time, with the briefest possible epitome of what they knew, or rather of how little they knew, to account for this later slavish adherence to authority by unwillingness to reason independently, or to observe natural phenomena intelligently, still less to experiment with them. It is, then, rather the brief history of an epochal discovery than an effort to trace out its far-reaching consequences that I have endeavored to give.