Humanist grammar [secondary] schools were established in London by merchants and guilds. In 1510, the founder and dean of St. Paul's School placed its management in the hands of London "citizens of established reputation" because he had lost confidence in the good faith of priests and noblemen. The sons of the nobility, attorneys, and merchants were starting to go to grammar school now instead of being taught at home by a tutor. At school, they mingled with sons of yeomen, farmers, and tradesmen, who were usually poor. The usual age of entry was six or seven. Classical Latin and Greek were taught and the literature of the best classical authors was read. Secondary education teachers were expected to know Latin and have studied the ancient philosophers, history, and geography. The method of teaching was for the teacher to read textbooks to the class from a prepared curriculum. The students were taught in Latin and expected not to speak English in school. They learned how to read and to write Latin, to develop and amplify a theme by logical analysis, and to essay on the same subject in the narrative, persuasive, argumentative, commending, consoling, and inciting styles. They had horn books with the alphabet and perhaps a Biblical verse on them. This was a piece of wood with a paper on it held down by a sheet of transparent horn. They also learned arithmetic (solving arithmetical problems and casting accounts). Disobedience incurred flogging by teacher as well as by parents. Spare the rod and spoil the child was the philosophy. Schools now guarded the morals and behavior of students. There were two week vacations at Christmas and at Easter. Royal grammar books for English and Latin were proclaimed by Henry in 1543 to be the only grammar book authorized for students. In 1545, he proclaimed a certain primer of prayers in English to be the only one to be used by students.

The first school of humanist studies arose in Oxford with the Foundation of Corpus Christi College in 1516 by Bishop Richard Fox. It had the first permanent Reader or Professor in Greek. The Professor of Humanity was to extirpate all barbarisms by the study of Cicero, Sallust, Valerius Maximus, and Quintilian. The third Reader of Theology was to read texts of the Holy Fathers but not those of their commentators. Oxford University was granted a charter which put the greater part of the town under control of the Chancellor and scholars. The mayor of Oxford was required to take an oath at his election to maintain the privileges and customs of the university. Roman law and other Regius professorships were founded by the king at Oxford and Cambridge. Teaching of undergraduates was the responsibility of the university rather than of the colleges, though some colleges had live-in teachers as students. Most colleges were exclusively for graduate fellows, though this was beginning to change. The university took responsibility for the student's morals and behavior and tutors sometimes whipped the undergraduates. For young noblemen, a more important part of their education than going to university was travel on the continent with a tutor. This exposure to foreign fields was no longer readily available through war or pilgrimage. The purpose was practical - to learn about foreign people and their languages, countries, and courts. Knowledge of the terrain, resources, prosperity, and stability of their countries was particularly useful to a future diplomatic or political career.

The physicians of London were incorporated to oversee and govern the practice of medicine. A faculty of physicians was established at Oxford and Cambridge. A Royal College of Physicians was founded in London in 1518 by the King's physician. The College of Physicians taught more practical medicine and anatomy than the universities. Only graduates of the College of Physicians or of Oxford or Cambridge were allowed to practice medicine or surgery.

Medical texts were Hippocrates and Galen. These viewed disease as only part of the process of nature without anything divine. They stressed empiricism, experience, collections of facts, evidences of the senses, and avoidance of philosophical speculations. Hippocrates had asserted that madness was simply a disease of the brain and then Galen had agreed and advocated merciful treatment of the insane. Galen's great remedies were proper diet, exercise, massage, and bathing. He taught the importance of a good water supply and good drainage. Greek medicinal doctrines were assumed, such as that preservation of the health of the body was dependant on air, food, drink, movement and repose, sleeping and waking, excretion and retention, and the passions. It was widely known that sleep was restorative and that bad news or worry could spoil one's digestion. An Italian book of 1507 showed that post-mortem examinations could show cause of death by gallstones, heart disease, thrombosis of the veins, or abscesses. In 1540 began the practice of giving bodies of hanged felons to surgeons to dissect. This was to deter the commission of felony. There was some feeling that dissection was a sacrilege, that the practice of medicine was a form of sorcery, and that illness and disease should be dealt with by prayer and/or atonement because caused by sin, the wrath of God, or by the devil. In 1543, Flemish physician Andreas Vesalius, who had secretly dissected human corpses, published the first finely detailed description of human anatomy. In it, there was no missing rib on one side of man, and this challenged the theory of the woman Eve having been made from a rib of the man Adam. Food that was digested was thought to turn into a vapor which passed along the veins and was concreted as blood, flesh, and fat. After 1546 there was a book listing hundreds of drugs and explaining how to prepare them, but their use was by trial and error.

Students were beginning to read for the bar by their own study of the newly available printed texts, treatises, and collections of statute law and of cases, instead of listening in court and talking with attorneys.

In 1523, Anthony Fitzherbert wrote "Boke of Husbandry", which set forth the most current methods of arable farming, giving details of tools and equipment, advice on capital outlay, methods of manuring, draining, ploughing, and rick-building. It was used by many constantly, and was often carried around in the pocket. This began a new way to disseminate new methods in agriculture. He also wrote a "Boke of Surveying", which relied on the perch rod and compass dial, and gave instruction on how to set down the results of a survey. In 1533, Gemma Frisius laid down the principles of topographical survey by triangulation. This improved the quality of surveys and produced accurate plots.

Geoffrey Chaucer's "Canterbury Tales" was a popular book. Through Chaucer, London English became a national standard and the notion of "correct pronunciation" came into being.

The discoveries and adventures of Amerigo Vespucci, a Portuguese explorer, were widely read. The North and South American continents were named for him.

London merchant guilds began to be identified mainly with hospitality and benevolence instead of being trading organizations. Twelve great companies dominated city politics and effectively chose the mayor and aldermen. They were, in order of precedence, Mercers, Grocers, Drapers, Fishmongers, Goldsmiths, Skinners, Tailors, Haberdashers, Ironmongers, Salters, Vintners, and the Clothworkers (composed from leading fullers and shearmen). The leading men of these guilds were generally aldermen and the guilds acted like municipal committees of trade and manufactures. Then they superintended the trade and manufactures of London much like a government department. They were called Livery Companies and categorized their memberships in three grades: mere membership, livery membership, and placement on the governing body. Livery members were distinguished by having the clothing of the brotherhood [its livery] and all privileges, and proprietary and municipal rights, in the fullest degree. They generally had a right to a place at the Company banquets. They were invited by the governing body, as a matter of favor, to other entertainments. These liverymen were usually those who had bought membership and paid higher fees because they were richer. Their pensions were larger than those of mere members. Those with mere membership were freemen who had only the simple freedom of the trade. The masters were usually householders. The journeymen, yeomanry, bachelors were simple freemen. Most of these companies had almshouses attached to their halls for the impoverished, disabled, and elderly members and their widows and children. For instance, many members of the Goldsmiths had been blinded by the fire and smoke of quicksilver and some members had been rendered crazed and infirm by working in that trade. The freedom and rights of citizenship of the city could only be obtained through membership in a livery company.

A lesser guild, the Leathersellers, absorbed the Glovers, Pursers, and Pouchmakers. These craftsmen then became wage earners of the Leathersellers, but others of these craftsmen remained independent. Before, the Whittawyers, who treated horse, deer, and sheep hides with alum and oil, had become wage earners for the Skinners.