It was widely known that sleep was restorative and that bad news or worry could spoil one's digestion. An Italian book of 1507 showed that post-mortem examinations could show cause of death by gallstones, heart disease, thrombosis of the veins, or abscesses. In 1540 began the practice of giving bodies of hanged felons to surgeons to dissect. This was to deter the commission of felony. There was some feeling that dissection was a sacrilege, that the practice of medicine was a form of sorcery, and that illness and disease should be dealt with by prayer and/or atonement because caused by sin, the wrath of God, or by the devil. Food that was digested was thought to turn into a vapor which passed along the veins and was concreted as blood, flesh, and fat. After 1546, there was a book listing hundreds of drugs with preparation directions, but their use and application was by trial and error.

Flemish physician Andreas Vesalius, secretly dissected human corpses, finding them hanging on public gibbets or competing with dogs for those incompletely buried in cemeteries. He begged doctors to allow him to examine the bodies of their fatal cases. He ingratiated himself with judges who determined the time and place of execution of criminals. In 1543 he published the first finely detailed description of human anatomy. In it, there was no missing rib on one side of man, and this challenged the theory of the woman Eve having been made from a rib of the man Adam.

In the 1540s, Ambroise Pare from France, a barber-surgeon who was the son of a servant, was an army surgeon. Wounds at this time were treated with boiling oil and spurting vessels were closed by being seared with a red-hot iron. After he ran out of boiling oil, he observed that the soldiers without this treatment were healing better than those with this treatment. So he advocated ceasing the practice of cauterizing wounds. He also began tying arteries with cord to stop their bleeding after amputation many other surgical techniques.

In Switzerland, Theophrastus Paracelsus, an astrologer and alchemist who later became a physician, did not believe that humor imbalance caused disease nor in treatment by bloodletting or purging. He believed that there were external causes of disease, e.g. toxic matter in food, contagion, defective physical or mental constitution, cosmic influences differing with climate and country, or affliction sent Providence. He urged that wounds be kept clean rather than given poultices. In 1530, he pioneered the application of chemistry to physiology, pathology, and the treatment of disease by starting clinical diagnosis and treatment of disease by highly specific medicines, instead of by cure-alls. For instance, he used alkalis to treat disease, such as gout, indicated by certain substances in the urine, which also started urinalysis. He perceived that syphilis was caused by contagion and used mercury to cure it. He found curative powers also in opium, sulphur, iron, and arsenic. Opium was made by drying and cooking the capsule of the poppy and was one of the few really effective early drugs. Paracelsus urged alchemists to try to prepare drugs from minerals for the relief of suffering. He claimed to acquire knowledge of cures through spiritual contacts to occult wisdom. He believed that a human being has an invisible body as well as a visible one and that it is closely attuned to imagination and the spiritual aspect of an individual. He noticed that one's attitudes and emotions, such as anger, could affect one's health. He sometimes used suggestion and signs to help a patient form mental images, which translated into cures. He saw insanity as illness instead of possession by evil spirits.

Students were beginning to read for the bar by their own study of the newly available printed texts, treatises, and collections of statute law and of cases, instead of listening in court and talking with attorneys.

In 1523, Anthony Fitzherbert wrote "Boke of Husbandry", which set forth the most current methods of arable farming, giving details of tools and equipment, advice on capital outlay, methods of manuring, draining, ploughing, and rick-building. It was used by many constantly, and was often carried around in the pocket. This began a new way to disseminate new methods in agriculture. He also wrote a "Boke of Surveying", which relied on the perch rod and compass dial, and gave instruction on how to set down the results of a survey. In 1533, Gemma Frisius laid down the principles of topographical survey by triangulation. This improved the quality of surveys and produced accurate plots.

Geoffrey Chaucer's "Canterbury Tales" was a popular book. Through Chaucer, London English became a national standard and the notion of "correct pronunciation" came into being.The discoveries and adventures of Amerigo Vespucci, a Portuguese explorer, were widely read. The North and South American continents were named for him.

London merchant guilds began to be identified mainly with hospitality and benevolence instead of being trading organizations. Twelve great companies dominated city politics and effectively chose the mayor and aldermen. They were, in order of precedence, Mercers, Grocers, Drapers, Fishmongers, Goldsmiths, Skinners, Tailors, Haberdashers, Ironmongers, Salters, Vintners, and the Clothworkers (composed from leading fullers and shearmen). The leading men of these guilds were generally aldermen and the guilds acted like municipal committees of trade and manufactures. Then they superintended the trade and manufactures of London much like a government department. They were called Livery Companies and categorized their memberships in three grades: mere membership, livery membership, and placement on the governing body. Livery members were distinguished by having the clothing of the brotherhood [its livery] and all privileges, and proprietary and municipal rights, in the fullest degree. They generally had a right to a place at the Company banquets. They were invited by the governing body, as a matter of favor, to other entertainments. These liverymen were usually those who had bought membership and paid higher fees because they were richer. Their pensions were larger than those of mere members. Those with mere membership were freemen who had only the simple freedom of the trade. The masters were usually householders. The journeymen, yeomanry, bachelors were simple freemen. Most of these companies had almshouses attached to their halls for the impoverished, disabled, and elderly members and their widows and children. For instance, many members of the Goldsmiths had been blinded by the fire and smoke of quicksilver and some members had been rendered crazed and infirm by working in that trade. The freedom and rights of citizenship of the city could only be obtained through membership in a livery company.

A lesser guild, the Leathersellers, absorbed the Glovers,
Pursers, and Pouchmakers, some of whom became wage earners of the
Leathersellers. But others of these craftsmen remained independent. The
Whittawyers, who treated horse, deer, and sheep hides with alum and
oil, had become wage earners for the Skinners.

Londoners went to the fields outside the city for recreation and games. When farmers enclosed some suburban common fields in 1514, a crowd of young men marched out to them and, crying "shovels and spades", uprooted the hedges and filled in the ditches, thus reclaiming the land for their traditional games. The last major riot in London was aroused by a speaker on May Day in 1517 when a thousand disorderly young men, mostly apprentices, defied the curfew and looted shops and houses of aliens. A duke with two thousand soldiers put it down in mid-afternoon, after which the king executed fifteen of the rioters.