There was progress in health. Scurvy virtually disappeared as a cause of death due to the eating of more vegetables. People were cleaner when wearing cotton, which had to be washed. In 1721, free inoculations for smallpox began in England, pioneered by Lady Mary Wortley Montague, also a poet and letter writer. She led the way by having herself and her son inoculated. Theologicians denounced this practice as a diabolical interference with disease sent by Providence for the punishment of sin. Sarah Wallen Mapp was a famous bone-setter. In 1727 surgeon William Cheselden, whose master was specially licensed to perform the operation of removing stones in the hospital, reduced the death rate for removing stones due to hemorrhage, shock, and infection down to 17% by his invention of a lateral operation. He also published an anatomy book and treated certain kinds of blindness by forming an opening in the eye to serve as an artificial pupil. In 1736, Claudius Aymand conducted the first successful appendectomy.

Nutritional deficiency diseases were beginning to be understood. In 1753, James Lind, a surgeon in the navy who noted that more men died of scurvy than in battle, published his work on his dietary controlled experiment on seamen showing that oranges, lemons, limes, green food, and onions cured scurvy. He published his methods of prevention and cure of malarial fevers and his method of disinfecting ships with the smoke of wood and gunpowder. In 1761, he discovered that steam from salt water was fresh, and proposed a method of distillation to supply ships with fresh water. In 1761 Giovanni Morgagni from Italy opined that disease resulted from a breakdown of organs and tissues that was viewable on autopsy. He wrote an extensive book showing the anatomy of diseases, e.g. affections of pericardium and aorta, (e.g. aneurysm), valve diseases, ulceration, rupture, dilation, and hypertrophy. He associated clinical observation with anatomy of disease. For example, pain on the left upper chest, numbness of the left arm, and difficulty breathing occurring together with exertion were associated with dilation of the aorta and hardening of arteries, which caused delay of blood in the aorta, in the heart, and in the lung vessels. Bernoulli showed that the living human body constantly changes so that all its particles are renewed in a certain number of years. Stephen Hale described the first quantitative estimate of blood pressure and fundamental characteristics of blood circulation. In 1728, Frenchman Dr. Pierre Fauchard, the father of dentistry, recommended rubbing one's teeth and gums with a piece of sponge.

Since three out of four babies died shortly after birth, beds in hospitals for pregnant women were established starting in 1739. The next year physicians began to replace midwives. A hospital was established for abandoned foundling children in 1739 so they wouldn't die, as they usually did, in the care of parishes or workhouses or be exposed in the streets or left on door steps of the wealthy. It was besieged by women with babies in their arms. In 1762 a statute made the principles of the foundling hospital obligatory for all London parish children under six; they were to be sent to nurses outside London who were to be paid at least 2s. a week by the parish. In 1766, this was extended to all parishes, and nurses who cared for a child well for a year was given a reward of at least 10s. Also, parish children were not allowed to be apprenticed for more than seven years or until age 21 and an apprentice fee of at least 4 pounds, 2s. was to be paid to the master or mistress by the parish.

After 1740, there was a steady growth of population due to improved midwifery. William Smellie taught scientific midwifery in London from 1741 and wrote a "Treatise on Midwifery" in 1752, which had a clear explanation of the mechanism of labor. At this time there were several maternity hospitals. Forceps existed for difficult deliveries. In 1750, Dr. Cadogan wrote his book: "An Essay on the Nursing and Management of Children, which made a great improvement in the care of young children. For instance, it recommended loose clothing, no tight swaddling clothes, and a simple diet. Swaddling clothes were used to retain a baby's evacuations but produced discomfort and serious skin conditions. A hospital was founded for venereal diseases in 1746, another as an asylum for the penitent and orphaned girls who might otherwise be inclined to prostitution, and yet another for prostitutes in 1758. Coitus interruptus was widely used for birth control. There were also clandestine abortions and intentional neglect of newborns.

Melancholy was widespread. Suicides were frequent and drugs were sold for this purpose. In 1725, the mentally ill were classified as curable or incurable. There were many private asylums. A lunatic who was furiously mad and dangerous was required to be safely locked up or chained in his place of settlement. There were frequent and dangerous abuses in madhouses, so in 1774, no one was to keep or confine more than one lunatic without a license granted by the Royal College of Physicians or else forfeit 500 pounds. A Justice of the Peace and a physician inspected all madhouses to observe conditions and care of patients there. If refused admittance, the license was forfeited.

In 1712 was the last time a monarch touched a person to cure him of a malady such as scrofula.

In 1743 surgery students began to dissect corpses with their own hands to better learn anatomy. In 1744 the Company of Surgeons was separated out of the Company of Barber-Surgeons. The barbers were proscribed from performing surgery and had to have a separate corporation from the surgeons because of the ignorance and unskillfulness of barbers healing wounds, blows, and hurts e.g. by blood letting and drawing of teeth. There was a Surgeon's Hall, officers chosen by the surgeons, and bylaws. The surgeons were required to examine candidates for the position of surgeon in the king's army and navy. They were exempted from parish, ward, and leet offices, and juries. In 1752, a statute provided that the corpses of murderers were to be sent to the Surgeon's Hall to be anatomized, for the purpose of deterring murders. The penalty for rescuing the corpse of a murderer was to suffer death.

The first dispensary for the poor was established in 1769 to give free medicine and treatment to the infant poor, and then to the infants of the industrious poor.

The progress of science was seen to threaten the authority of the church. There was a general belief in God, but not much attention to Jesus. Feared to come were free thought, rationalism, and atheism. There was still a big gap between local parsons and bishops, who were educated, well-off, and related to the aristocracy. On the whole, preachers talked about morality and Christian belief. They stressed good works and benevolence. But many Protestant clergy were more concerned with their own livings than with their parishioners. They were indolent and did not set a good example of moral living.

From 1715, Freemasonry spread and swiftly provided a spiritual haven for those who believed in God and desired ritual and mysticism.