On January 5th, 1716, Wills was appointed to the colonelcy of the 3rd Regiment of the line, and on the death of Lord Cadogan was transferred in August, 1726, to that of the 1st Regiment of Foot Guards.

It was customary at all times for the King's company of the 1st Guards to fly the Royal Standard, which was carried by that company on all state occasions. It was of crimson silk throughout, with the King's cypher and crown in the middle and the arms of the three kingdoms quartered in the four corners. The staff of this standard was also more ornamented than that of the other twenty-seven companies. The lieutenant-colonel's colours were also of crimson silk throughout. These colours were renewed every seven years.

In 1723 the King went to Hanover, when a camp was formed in Hyde Park under the command of Lieut.-Colonel Wills. He had been elected M.P. for Totnes in 1714, and he represented that borough till 1741. In 1725 he was made Knight of the Bath and Privy Councillor.

In 1733, in consequence of the increase of smuggling carried on even in London, Strickland, Secretary for War, addressed a letter in the form of a warrant to the Governor of the Tower and to the officers in command of the Guards, authorizing them to furnish detachments of men to assist in securing contraband goods; and in consequence of the increase of the duties to be performed by the men of the Foot Guards, their establishment was raised in 1739 by ten men per company.

In 1740, as the political horizon on the Continent was threatening, Walpole had to choose between declaring war with Spain and resigning. He disapproved of war, but rather than resign declared it. The people of London were delighted and rang the bells in the steeples. "Ah!" said Walpole; "they are ringing the bells now; they soon will be wringing their hands." Camps, in anticipation of hostilities, were ordered to be formed in various parts of England. In March orders were conveyed to Sir Charles Wills and others to direct their officers to provide themselves with tents and everything needful for encamping, and those troops under Sir Charles were to occupy Hounslow. He superintended the formation of the camp where the whole of the Horse and Foot Guards were to assemble, and previous to departing they paraded in Hyde Park, on June 15th, under Sir Charles, who had a lieutenant-general and a major-general on the staff with him. Thence he proceeded to the encampment on the Heath marked out for the purpose.

The twenty-four companies of the 1st Guards under the command of Colonel Richard Ingoldsby, second major of the regiment, remained encamped on Hounslow from June 16th for several months—in fact, till the middle of October.

Sir Charles Wills was now filling the post of General Commander of the King's forces, but had been failing in health and strength, and soon became quite unable to take any active work; and he died on December 25th, Christmas Day, 1741, and was buried in Westminster Abbey.

He had never been married. He had purchased land at Claxton, and this and all he had he bequeathed to Field-Marshal Sir Robert Rich, Bart., of Roxhill, in Suffolk, Governor of Chelsea Hospital.