SYN: Juxtaposition, neighborhood, nearness, proximity.
ANT: Distance, remoteness, separation, removal.
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KEY: Vicious.
SYN: Corrupt, faulty, defective, bad, morbid, peccant, debased, profligate, unruly, impure, depraved.
ANT: Pure, sound, perfect, virtuous, healthy.
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KEY: Vicissitude.
SYN: Change, alternation, interchange, revolution, mutation, ups and downs.
ANT: Perpetuity, stability, changelessness, immutability, fixity.