"Great about this time," says one of his biographers, "was his spiritual conflict. His natural inclination, his lively and active disposition, his father's favor, the respect of his friends and acquaintance, strongly pressed him to embrace the glory and pleasures of this world, then, as it were, courting and caressing him, in the bloom of youth, to accept them. Such a combined force seemed almost invincible; but the earnest supplication of his soul being to the Lord for preservation, He was pleased to grant such a portion of his power or spirit, as enabled him in due time to overcome all opposition, and with an holy resolution to follow Christ, whatsoever reproaches or persecutions might attend him."

About the year 1666, and when he was twenty-two years of age, his father committed to his care and management a considerable estate in Ireland, which occasioned his residence in that country. Thomas Lee, whom we have before mentioned, being at Cork, and Penn hearing that he was to be shortly at a meeting in that city, went to hear him; and by the preaching of this man, which had made some impression on his mind ten years before, he was now thoroughly and effectually established in the faith of the Friends, and afterwards constantly attended the meetings of that people. Being again at a meeting at Cork, he, with many others, was apprehended, and carried before the mayor, and, with eighteen of his associates, was committed to prison; but he soon obtained his discharge. This imprisonment was so far from terrifying, that it strengthened him in his resolution of a closer union with that people, whose religious innocence was the only crime for which they suffered. He now openly joined with the Quakers, and brought himself under the reproach of that name, then greatly ridiculed and hated. His former companions turned their caresses and compliments into bitter gibes and malignant derision.

His father, receiving information of what had passed, ordered him home; and the son readily obeyed. His deportment attested the truth of the information his father had received. He now again attempted, by every argument in his power, to move him; but finding it impossible to obtain a general compliance with the customs of the times, he would have borne with him, provided he would have taken off his hat, in the presence of the king, the duke of York, and himself.

This being proposed to the son, he desired time to consider of it. His father, supposing this to be with an intention of consulting his friends, the Quakers, assured him that he should see the face of none of them, but retire to his chamber till he could return him an answer. "Accordingly he withdrew, humbling himself before God, with fasting and supplication, to know his heavenly mind and will, and became so strengthened in his resolution, that, returning to his father, he humbly signified that he could not comply with his desire."

All endeavors proving ineffectual to shake his constancy, his father, seeing himself utterly disappointed in his hopes, again turned him out of doors. After a considerable time, his steady perseverance evincing his integrity, his father's wrath became somewhat abated, so that he winked at his return to, and continuance with, his family; and though he did not publicly seem to countenance him, yet, when imprisoned for being at meetings, he would privately use his interest to get him released. In the twenty-fourth year of his age, he became a minister among the Quakers, and continued his useful labors, inviting the people to that serenity and peace of conscience he himself witnessed, till the close of his life.

A spirit warmed with the love of God, and devoted to his service, ever pursues its main purpose; thus, when restrained from preaching, Penn applied himself to writing. The first of his publications appears to have been entitled "Truth Exalted." Several treatises were also the fruits of his solitude, particularly the one entitled "No Cross, no Crown."

In the year 1670, came forth the Conventicle Act, prohibiting Dissenters' meetings, under severe penalties. The edge of this new weapon was soon turned against the Quakers, who, not accustomed to flinch in the cause of religion, stood particularly exposed. Being forcibly kept out of their meeting-house in Grace Church street, they met as near it, in the open street, as they could: and Penn, preaching there, was apprehended, and committed to Newgate. At the next sessions of the Old Bailey, together with William Mead, he was indicted for "being present at, and preaching to, an unlawful, seditious, and riotous assembly." At his trial he made a brave defence, discovering at once both the free spirit of an Englishman and the undaunted magnanimity of a Christian, insomuch that, notwithstanding the frowns and menaces of the bench, the jury acquitted him.

Not long after this trial, and his discharge from Newgate, his father died, perfectly reconciled to his son, and left him both his paternal blessing, and an estate of fifteen hundred pounds a year. He took leave of his son with these remarkable words: "Son William, if you and your friends keep to your plain way of preaching, and keep to your plain way of living, you will make an end of the priests to the end of the world. Bury me by my mother; live all in love; shun all manner of evil; and I pray God to bless you all; and he will bless you."

In February, 1670, Penn was preaching at a meeting in Wheeler street, Spitalfields, when he was pulled down, and led out by soldiers into the street, and carried away to the Tower, by order of Sir John Robinson, lieutenant of the Tower. He was examined before Sir John and several others, and then committed, by their orders, to Newgate, for six months. Being at liberty at the expiration of that time, he soon after went to Holland and Germany, where he zealously endeavored to propagate the principles of the Quakers.

In March, 1680, he obtained from Charles II. a grant of the territory which now bears the name of Pennsylvania. This was in compensation of a crown debt due to his father. Having previously published an account of the province, inviting emigrants to accompany him thither, he set sail in June, 1682, with many friends, especially Quakers, and after a prosperous voyage of six weeks, they came within sight of the American coast. Sailing up the river Delaware, they were received by the inhabitants with demonstrations of joy and satisfaction. Having landed at Newcastle, a place mostly inhabited by the Dutch, Penn next day summoned the people to the court-house, where possession of the country was legally given him.