While the Yamassees were thus desolating the southern frontiers, the Congarees, Catawbas, and Cherokees came down in great force on the north. The southern division of the Indians in this war was computed at 6,000 bowmen, and the northern at 600 or 1,000. A company, which was sent against the northern division, was betrayed by the treachery of an Indian; the captain was slain, and his party defeated. In one place, seventy whites and about forty negroes, having bravely defended their post against the northern division, capitulated, and, after their surrender are said to have been perfidiously massacred. Flushed with their success, the Indians went on burning, murdering, and plundering. They were soon, however, met by a band of militia, raised on the emergency, and totally defeated.

The governor of South Carolina advanced with an army, and, at a place called Saltcalches, a bloody battle was fought. The Indians, uttering fearful war-cries and yells, sometimes retired behind the bushes, and then, when the English were beginning to be encouraged with the hope of success, they returned to the fight with redoubled fury. They were, however, at last wholly defeated, and driven across the Savannah River. The Yamassees, despairing of being able to expel or exterminate the whites, and cherishing a spirit of bold independence, fled to Florida, where they were afterwards troublesome to the settlements in that vicinity.

In April, 1730, a commissioner was sent to treat with the Cherokees. A general assembly of the chiefs was thereupon summoned, who swore allegiance to King George. A treaty was made, which was kept inviolate by the Indians for thirty years. In 1760, they again made war on the English. Parties of them had assisted in the expedition against Fort du Quesne. In that enterprise they were treated with coldness and neglect, and felt themselves insulted. Returning home, as many of the warriors had lost their horses, they caught and appropriated such as they found loose in the woods. The Virginians, roused by these aggressions, fell on them, killed twelve or fifteen, and took several prisoners.

The Cherokees were at once kindled into rage; they went home, and told their wrongs to their nation. The relatives of those who were slain breathed nothing but revenge. The French emissaries secretly fanned the flame, and added fresh fuel to their angry passions. The young warriors rushed down on the frontier settlements, and committed ravages on the defenceless inhabitants. They attacked the troops stationed at Fort Loudon, a portion of whom were killed, and the remainder confined within the fort. Still, the nation generally were averse to war, particularly as they heard that the English were making great preparations to attack them. They therefore sent thirty-two of their chief men to settle the difficulties in an amicable manner. The governor of North Carolina received them haughtily, and overwhelmed them with reproaches. Ouconnostota, who was considered a great warrior in the Cherokee nation, began to reply, but the governor would not hear him. This treatment greatly exasperated the Indians, who had now a new insult added to their other wrongs. The governor soon after marched for the country of the Congarees, 140 miles from Charleston, taking with him the Cherokee sachems, who were detained as prisoners, a guard being set over them. On reaching Fort George, they were shut up in a hut scarcely fit to accommodate a dozen soldiers, and were not allowed to see their friends, or even enjoy the light of day.

Here the governor opened a conference with the Indians, who had been assembled for the purpose. He had sent, among others, for Attakullakulla, or Little Carpenter, who was esteemed the wisest man in the nation, and the most attached of all to the English. By his request, Ouconnostota and two more of the chiefs were set free. Two others, who were delivered up as hostages, being put in irons, the Cherokees were alarmed and fled. Attakullakulla returned home to await the result. He was, however, soon summoned back, and finally a treaty was signed by the governor, and the head men of the Cherokees. Still, the remembrance of the treatment they had received lay deeply buried in the breasts of the Indians; and Attakullakulla, on account of his known attachment to the English, had little influence with them.

Ouconnostota, under a sense of his wrongs, was implacable and vindictive. He collected his warriors, made a fierce attack on the whites, killed fourteen men near Fort George, and besieged the garrison. He also contrived a stratagem to surprise the fort. He sent two Indian women, who were always welcome there, to decoy out the garrison; the lieutenant went forth to inquire the news, when Ouconnostota joined them, saying that he wished to see the commanding officer on important business. Accordingly, the captain, lieutenant, and ensign went out to meet him. The chief said he was going to Charleston to procure a release of prisoners, and wished a white man for a safeguard.

The request seemed reasonable, and the captain told him he should have one. No sooner was the answer returned, than Ouconnostota gave the signal agreed on, and nearly thirty guns were at once discharged on the English. The captain was killed, and the lieutenant and ensign were wounded. This treachery so exasperated the garrison, that the hostages in the fort were immediately put to death. In the evening, the Indians approached the fort, and, after firing their guns, and crying out in the Cherokee language, “Fight manfully and you shall be assisted,” they made a most furious attack, which they kept up all night. But they were so well met by the fire of the troops within the fort, that they were obliged to retire.

Disappointed in this project, they turned their rage upon the Indian traders, and massacred them. The war now became general; large parties of warriors fell on the defenceless frontiers, and cut off many families. About 200 of them attacked the fort at Ninety-Six, but were obliged to retire with loss. In the mean time an expedition was planned against the Indians; and presents were given to such Creeks, Chickasaws, and Catawbas, as joined in the war against the Cherokees. Their towns in the lower settlement were attacked and destroyed, and many of the natives slain. After this, a message was sent to Fort Loudon, requesting the commanding officers to use their best endeavours to obtain peace with the Cherokees of the upper towns. But they were unsuccessful, and an attack on the middle settlements was therefore resolved upon.