With the French out of the country, and with William Pitt out of office and incapacitated by age, the Colonies began to feel the oppression of a British policy which British statesmen and British historians to-day most bitterly condemn. America's opposition to tyranny found its natural expression in the Battle of Lexington, April 19, 1775. The fires of patriotism leapt through the continent and the little settlement at Pittsburgh was quickly aflame with the national spirit. On May 16th a convention was held at Pittsburgh, which resolved that

This committee have the highest sense of the spirited behavior of their brethren in New England, and do most cordially approve of their opposing the invaders of American rights and privileges to the utmost extreme, and that each member of this committee, respectively, will animate and encourage their neighborhood to follow the brave example.

No foreign soldiers were sent over the mountains to Pittsburgh, but a more merciless foe, who would attack and harass with remorseless cruelty, was impressed into the English service, despite the horrified protests of some of her wisest statesmen. American treaties with the Indians had no force against the allurements of foreign gold, and under this unholy alliance men were burnt at the stake, women were carried away, and cabins were destroyed.

With the aim of regaining the friendship of the Indians, Congress appointed commissioners who met the tribes at Pittsburgh; and Colonel George Morgan, Indian agent, writes to John Hancock, November 8, 1776:

I have the happiness to inform you that the cloud that threatened to break over us is likely to disperse. The Six Nations, with the Muncies, Delawares, Shawanese, and Mohicans, who have been assembled here with their principal chiefs and warriors to the number of 644, have given the strongest assurance of their determination to preserve inviolate the peace and neutrality with the United States.

These amicable expectations were not realized, and General Edward Hand came to Pittsburgh the next year and planned an expedition against the Indians. Colonel Broadhead took out Hand's expedition in the summer and burned the Indian towns.

The depreciation of paper currency, or Continental money, had by this time brought the serious burden of high prices upon the people. The traders, who demanded apparently exorbitant rates for their goods, were denounced in public meetings at Pittsburgh as being "now commonly known by the disgraceful epithet of speculators, of more malignant natures than the savage Mingoes in the wilderness." This hardship grew in severity until the finances were put upon a more stable basis.

In 1781, there was demoralization and mutiny at Fort Pitt, and General William Irvine was put in command. His firm hand soon restored the garrison to obedience. The close of the war with Great Britain in that year was celebrated by General Irvine by the issue of an order at the fort, November 6, 1781, requiring all, as a sailor would say, "to splice the mainbrace." This order read as follows:

The commissioners will issue a gill of whisky, extraordinary, to the non-commissioned officers and privates, upon this joyful occasion.

The Penn family had purchased the Pittsburgh region from the Indians in 1768, and they would offer none of it for sale until 1783. Up to this time they had held the charter to Pennsylvania; but as they had maintained a steadfast allegiance to the mother country, the general assembly annulled their title, except to allow them to retain the ownership of various manors throughout the State, embracing half a million acres.