"To induce sleep, take an Orangeine powder immediately before retiring. When wakeful, an Orangeine powder will have a normalizing, quieting effect."

It is also recommended as a good thing to begin the day's work on in the morning—that is, take Orangeine night, morning and between meals!

These powders pretend to cure asthma, biliousness, headaches, colds, catarrh and grip (dose: powder every four hours during the day for a week!—a pretty fair start on the Orangeine habit), diarrhea, hay fever, insomnia, influenza, neuralgia, seasickness and sciatica.

Of course, they do not cure any of these; they do practically nothing but give temporary relief by depressing the heart. With the return to normal conditions of blood circulation comes a recurrence of the nervousness, headache, or what not, and the incentive to more of the drug, until it becomes a necessity. In my own acquaintance I know half a dozen persons who have come to depend on one or another of these headache preparations to keep them going. One young woman whom I have in mind told me quite innocently that she had been taking five or six Orangeine powders a day for several months, having changed from Koehler's powders when some one told her that the latter were dangerous! Because of her growing paleness her husband had called in their physician, but neither of them had mentioned the little matter of the nostrum, having accepted with a childlike faith the asseverations of its beneficent qualities. Yet they were of an order of intelligence that would scoff at the idea of drinking Swamp-Root.

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An Acetanilid Death Record.

This list of fatalities is made up from statements published in the newspapers. In every case the person who died had taken to relieve a headache or as a bracer a patent medicine containing acetanilid, without a doctor's prescription. This list does not include the case of a dog in Altoona, Pa., which died immediately on eating some sample headache powders. The dog did not know any better.

Mrs. Minnie Bishop, Louisville, Ky.; Oct. 16, 1903.
Mrs. Mary Cusick and Mrs. Julia Ward, of 172 Perry Street,
New York City; Nov. 27, 1903.
Fred. P. Stock, Scranton, Pa.; Dec. 7, 1903.
C. Frank Henderson, Toledo, 0.; Dec. 13, 1903.
Jacob E. Staley, St. Paul, Mich.; Feb. 18, 1904.
Charles M. Scott, New Albany, Ind.; March 15, 1904.
Oscar McKinley, Pittsburg, Pa.; April 13, 1904.
Otis Staines, student at Wabash College; April 13, 1904.
Mrs. Florence Rumsey, Clinton, la.; April 23, 1904.
Jenny McGee, Philadelphia, Pa.; May 26, 1904.
Mrs. William Mabee, Leoni, Midi.; Sept. 9, 1904.
Mrs. Jacob Friedman, of South Bend, Ind.; Oct. 19, 1904.
Miss Libbie North, Rockdale, N. Y.; Oct. 26, 1904.
Margaret Hanahan, Dayton, O.; Oct. 29, 1904.
Samuel Williamson, New York City; Nov. 21, 1904.
George Kublisch, St. Louis, Mo.; Nov. 24, 1904.
Robert Breck, St. Louis, Mo.;'Nov. 27, 1904.
Mrs. Harry Haven, Oriskany Falls, N. Y.; Jan. 17, 1905.
Mrs. Jennie Whyler, Akron, 0.; April 3, 1905.
Mrs. Augusta Strothmann, St. Louis, Mo.; June 20, 1905.
Mrs. Mary A. Bispels, Philadelphia, Pa.; July 2, 1905.
Mrs. Thos. Patterson, Huntington, W. Va.; Aug. 15, 1905.