In the twelfth year of his age, a stubborn, painful, and malignant ulcer, broke out upon his left thigh; which, for near five years, defeated all the art of the surgeons and physicians, and not only afflicted him with most excruciating pains, but exposed him to such sharp and tormenting applications, that the disease and remedies were equally insufferable. Then it was, that his own pain taught him to compassionate others, and his experience of the inefficacy of the methods then in use, incited him to attempt the discovery of others more certain.
He began to practise, at least, honestly, for he began upon himself; and his first essay was a prelude to his future success, for having laid aside all the prescriptions of his physicians, and all the applications of his surgeons, he at last, by tormenting the part with salt and urine, effected a cure.
That he might, on this occasion, obtain the assistance of surgeons with less inconvenience and expense, he was brought, by his father, at fourteen, to Leyden, and placed in the fourth class of the publick school, after being examined by the master: here his application and abilities were equally conspicuous. In six months, by gaining the first prize in the fourth class, he was raised to the fifth; and, in six months more, upon the same proof of the superiority of his genius, rewarded with another prize, and translated to the sixth; from whence it is usual, in six months more, to be removed to the university.
Thus did our young student advance in learning and reputation, when, as he was within view of the university, a sudden and unexpected blow threatened to defeat all his expectations.
On the 12th of November, in 1682, his father died, and left behind him a very slender provision for his widow, and nine children, of which the eldest was not yet seventeen years old.
This was a most afflicting loss to the young scholar, whose fortune was by no means sufficient to bear the expenses of a learned education, and who, therefore, seemed to be now summoned, by necessity, to some way of life more immediately and certainly lucrative; but, with a resolution equal to his abilities, and a spirit not so depressed and shaken, he determined to break through the obstacles of poverty, and supply, by diligence, the want of fortune.
He, therefore, asked, and obtained the consent of his guardians, to prosecute his studies, so long as his patrimony would support him; and, continuing his wonted industry, gained another prize.
He was now to quit the school for the university, but on account of the weakness yet remaining in his thigh, was, at his own entreaty, continued six months longer under the care of his master, the learned Winschotan, where he was once more honoured with the prize.
At his removal to the university, the same genius and industry met with the same encouragement and applause. The learned Triglandius, one of his father's friends, made soon after professor of divinity at Leyden, distinguished him in a particular manner, and recommended him to the friendship of Mr. Van Apphen, in whom he found a generous and constant patron.
He became now a diligent hearer of the most celebrated professors, and made great advances in all the sciences, still regulating his studies with a view, principally, to divinity, for which he was originally intended by his father; and, for that reason, exerted his utmost application to attain an exact knowledge of the Hebrew tongue.