Meconic acid, the peculiar acid of opium, which will be described under the head of that poison, is also probably a good antidote. Pettenkoffer correctly remarks that this acid has a great tendency to form very insoluble salts with the metallic oxides, particularly with the deutoxides, and above all when the acid is previously in union with a base which constitutes a soluble salt.[[1040]] On this account it must be a good antidote. Pettenkoffer adds, that the precipitating action of the meconates is the reason why “the operation of corrosive sublimate on the animal body is almost entirely prevented by opium.” Opium, however, cannot be safely used in such quantity as to decompose all the corrosive sublimate in a case of poisoning; for I find that an infusion of thirty-three grains is required to precipitate all which can be thrown down from a solution of five grains of the mercurial salt. I am not aware of any instances on record where poisoning with corrosive sublimate has been prevented or cured by opium given so as to decompose the salt; but a very remarkable case will be related under the head of Compound Poisoning, where the phenomena of its action were masked and altered in a singular manner. There is little doubt that the alkaline meconates must prove valuable antidotes for corrosive sublimate. At present an effectual barrier to their employment is their rarity; but they might be rendered more accessible, as a great quantity of meconate of lime, which is at present put to no use, is formed in the manufacture of muriate of morphia; and meconate of potass may easily be prepared in sufficient quantity from the meconate of lime.
It has been alleged by Dr. Buckler of Baltimore, that a mixture of gold-dust and iron filings is an effectual antidote; but Orfila denies this statement; and the fact if true would be unimportant, on account of the improbability of the materials being ever at hand in practice.[[1041]]
M. Mialhe suggested not long ago as an antidote the proto-sulphuret of iron prepared by decomposing sulphate of protoxide of iron by hydrosulphate of ammonia; and Orfila found that it is a perfect chemical antidote, which altogether prevents the poisonous action of corrosive sublimate, if administered to animals either before or immediately after the poison; but he further ascertained that the lapse of ten minutes was sufficient to render it of no use.[[1042]] It is difficult, however, to perceive why in this respect it should differ from white of egg or any other chemical antidote.
As to the old antidotes for poisoning with corrosive sublimate, such as the alkaline carbonates, the alkaline hydrosulphates, cinchona, mercury, charcoal,—Orfila has given them all a fair trial, and found them all inefficacious. It would appear, however, from a case related in a late American journal, that frequent doses of charcoal powder have much effect in soothing the bowels and allaying the inflammation after the poison is evacuated.[[1043]]
The treatment of mercurial salivation consists in exposure to a cool pure air, nourishing diet, and purgatives, if the intestinal canal is not already irritated. In some of the inflammatory affections it induces, venesection is required; in others it is hurtful. In some complaints induced by mercury, as in iritis, the poison appears to be its own antidote; for nothing checks the inflammation so soon and so certainly as mercurial salivation.
Dr. Finlay of the United States proposed to check mercurial salivation by small doses of tartar emetic frequently repeated, so as to act on the skin;[[1044]] and Mr. Daniell has recommended large doses of the acetate of lead as an effectual antidote for the same purpose.[[1045]] I have tried both of these plans several times with apparent success. In one instance particularly, where a severe salivation was threatened by the administration of six grains of calomel in three doses, and where profuse salivation, ulceration of the tongue and swelling of the face actually did commence with violence, the mercurial affection after a few days rapidly receded under the use of large doses of acetate of lead.—Dr. Klose, a German physician, says he has found iodine to possess the property of arresting the effects of mercury on the mouth.[[1046]] The iodide of potassium is generally acknowledged to be one of the best remedies for eradicating the constitutional infirmities left in many by severe courses of mercury.
A great deal might be said on the treatment of the secondary effects of poisoning with mercury. But a thorough investigation of the subject would lead to such details as would be inconsistent with the other objects of this work.
CHAPTER XV.
OF POISONING WITH COPPER
Poisoning with the salts of copper was not long ago a common accident, in consequence of the metal being much used in the fabrication of vessels for culinary and other domestic purposes, or ignorantly resorted to by confectioners and others to impart a good colour to sweetmeats and preserves. Such accidents have been materially diminished in frequency since the poisonous qualities of the metal, and the circumstances under which it is acted on by articles of food, have become known. Nevertheless they are still frequent enough. The diffusion among the common people of the knowledge of the properties of copper has also naturally led some persons to have recourse to its preparations for the purpose of self-destruction. Poisoning with copper has seldom been caused by the wilful act of another person; for the deep colour of its compounds and their strong disagreeable taste render it a difficult matter to administer them secretly. This, however, though difficult, is not impossible: whatever may be swallowed accidentally, may be also administered secretly. In 1795 a woman Inglis was tried at Aberdeen for administering sulphate of copper with intent to poison; but the charge was not proved.[[1047]] In 1842 an attempt was made at Béziers in France to poison a young woman by dissolving this salt in her coffee; but the first mouthful caused such a sense of constriction in the throat as to apprize her of something deleterious being present, and she escaped after suffering from soreness of the mouth, vomiting and cramps.[[1048]] A case of imputed poisoning with sulphate of copper has been related at page [76].