25th. No material change.

27th. Insensibility increased to coma; features shrunk; one stool passed in bed; pulse 128; skin livid, cold.

28th. Moribund; died the following day.

On examination after death (see pathology) extensive disease was found in the intestines, although, if the purging on the day of admission be excepted, not the slightest indication of it was given during life.

Case XI.

George English, æt. 25, carpenter. Admitted on the 29th day of fever, with a great degree of tenderness of the abdomen, extending especially over the hypogastric region; bowels said to be regular; pulse 90, of good strength; yet complains much of sense of debility.

30th. Pain of the abdomen continues, especially over the region of the bladder; urine passed in good quantity and freely; three stools; pulse 84.

32d. Tumour has appeared over the region of the bladder, unattended with pain; three stools; pulse 76.

33d. Hypogastrium still tumid, but without pain; other symptoms the same.

43d. No material change until this day, when he was suddenly seized with exceedingly acute pain in the region of the bladder; extreme tenderness on pressure; great restlessness, and great anxiety; vomiting of a yellow-coloured fluid; two stools; pulse 84, extremely feeble.