(2.) The membranes termed valves are so placed as to allow of the freest passage to the blood in the circle described, while they either altogether prevent or exceedingly impede its movement in any other direction.

(3.) The effect of a ligature placed around a vein and an artery, and of a puncture made above the ligature in the one vessel and below it in the other, demonstrate both the motion of the blood and the course of it. When a ligature is placed around a vein, that part of the vessel which is most distant from the heart becomes full and turgid on account of the accumulation of blood in it; while the part of the vessel which is between the ligature and the heart becomes empty and flaccid, because it has carried on its contents to the heart, and it can receive no fresh supply from the body. When, on the contrary, a ligature is placed around an artery, that portion of the vessel which lies between the ligature and the heart becomes full and turgid, and the other portion empty and flaccid. This can only be because the contents of the two vessels move in opposite directions,—from the heart to the artery, from the artery to the vein, and from the vein to the heart. At the same time, if the vein be punctured above the ligature, there will be little or no loss of blood; while if it be punctured below the ligature, the blood will continue to flow until the loss of it occasions death, which could not be unless the blood were in motion, nor unless the direction of its course were from the artery to the vein and from the vein to the heart.

(4.) If fluids be injected into the veins or arteries, whether of the dead or of the living body, they readily make their way and fill the vessels, if thrown in the direction stated to be the natural course of the circulation; but they are strongly resisted if forced in the opposite direction.

279. Such is the description, and with the exception of the first proof, such the evidence of the circulation of the blood in the human body, pretty much as it was given by the discoverer of it, the illustrious Harvey. Before the time of Harvey, a vague and indistinct conception that the blood was not without motion in the body had been formed by several anatomists. It is analogous to the ordinary mode in which the human mind arrives at discovery (chap. iii., p. 103), that many minds should have an imperfect perception of an unknown truth, before some one mind sees it in its completeness and fully discloses it. Having, about the year 1620, succeeded in completely tracing the circle in which the blood moves, and having at that time collected all the evidence of the fact, with a rare degree of philosophical forbearance, Harvey still spent no less than eight years in re-examining the subject, and in maturing the proof of every point, before he ventured to speak of it in public. The brief tract which at length he published was written with extreme simplicity, clearness, and perspicuity, and has been justly characterised as one of the most admirable examples of a series of arguments deduced from observation and experiment that ever appeared on any subject.

280. Cotemporaries are seldom grateful to discoverers. More than one instance is on record in which a man has injured his fortune and lost his happiness through the elucidation and establishment of a truth which has given him immortality. It may be that there are physical truths yet to be brought to light, to say nothing of new applications of old truths, which, if they could be announced and demonstrated to-day, would be the ruin of the discoverer. It is certain that there are moral truths to be discovered, expounded, and enforced, which, if any man had now penetration enough to see them, and courage enough to express them, would cause him to be regarded by the present generation with horror and detestation. Perhaps, during those eight years of re-examination, the discoverer of the circulation sometimes endeavoured in imagination to trace the effect which the stupendous fact at the knowledge of which he had arrived would have on the progress of his favourite science; and, it may be, the hope and the expectation occasionally arose that the inestimable benefit he was about to confer on his fellow men would secure to him some portion of their esteem and confidence. What must have been his disappointment when he found, after the publication of his tract, that the little practice he had had as a physician, by degrees fell off. He was too speculative, too theoretical, not practical. Such was the view taken even by his friends. His enemies saw in his tract nothing but indications of a presumptuous mind that dared to call in question the revered authority of the ancients; and some of them saw, moreover, indications of a malignant mind, that conceived and defended doctrines which, if not checked, would undermine the very foundations of morality and religion. When the evidence of the truth became irresistible, then these persons suddenly turned round and said, that it was all known before, and that the sole merit of this vaunted discoverer consisted in having circulated the circulation. The pun was not fatal to the future fame of this truly great man, nor even to the gradual though slow return of the public confidence even during his own time; for he lived to attain the summit of reputation.

281. It is then indubitably established that the whole blood of the body in successive streams is collected and concentrated at the heart. The object of the accumulation of a certain mass of it at this organ is to subject it to the action of a strong muscle, and thereby to determine its transmission with adequate force and precision through the different sets of capillary vessels.

282. In the accomplishment of this object the heart performs a twofold action; that of contraction and that of dilatation. The auricles contract and thereby diminish their cavities, then dilate and thereby expand them, and the one action alternates with the other. There is the like alternate contraction and dilatation of the ventricles. The first action is termed systole, the second diastole, and both are performed with force.

283. When the heart is laid open to view in a living animal, and its movements are carefully observed, it is apparent that the two auricles contract together; that the two ventricles contract together; that these motions alternate with each other, and that they proceed in regular succession. The interval between these alternate movements is, however, exceedingly short, and can scarcely be perceived when the heart is acting with full vigour; but it is evident when its action is somewhat languid.

284. When the ventricles contract, the apex of the heart is drawn upwards, and at the same time raised or tilted forwards. It is during this systole of the ventricles, and in consequence of this result of their action, that the apex of the heart gives that impulse against the walls of the chest which is felt in the natural state between the fifth and sixth ribs, and which just perceptibly precedes the pulse at the wrist.