When not yet eighteen years old, he was drafted into the North Carolina militia, and accompanied Gates in his unfortunate expedition through the Carolinas. After the war was over and the family had removed to South Carolina, William resumed his studies and was graduated at Hampton Sidney College—studied theology, and was ordained pastor of Fair Forest Church, in April, 1793.

The grandfather of Thomas Smith Williamson was Thomas Williamson, and his grandmother’s maiden name was Ann Newton, a distant relative of Sir Isaac and Rev. John Newton. They were both raised in Pennsylvania, but removed first to Virginia and then to the Carolinas, where they became the owners of slaves, the most of whom were purchased at their own request to keep them from falling into the hands of hard masters.

Thus Rev. William Williamson was born into the condition of slaveholder. By both his first and second marriage also, he became the owner of others, which, by the laws of South Carolina, would have been the property of his children. For the purpose of giving them their liberty, he removed, in 1805, from South Carolina to Adams County, Ohio. Before her marriage, Mary Smith had taught a number of the young negroes to read. And of their descendants quite a number are now in Ohio. It should be remembered that the Smiths and Williamsons of the eighteenth century thought it right, under the circumstances in which they were, to buy and hold slaves, but not right to sell them. They never sold any.

Thomas Smith Williamson inherited from his father a love for the study of God’s Word, and a practical sympathy for the down-trodden and oppressed, which were ever the distinguishing characteristics of his life. He was also blessed with a godly mother and with five earnest-working Christian sisters, four of whom were older than himself. He was converted during his stay at Jefferson College, Cannonsburg, Pa., where he graduated in 1820. Soon after, he began reading medicine with his brother-in-law, Dr. William Wilson of West Union, Ohio, and, after a very full course of reading, considerable practical experience, and one course of lectures at Cincinnati, Ohio, completed his medical education at Yale, where he graduated in medicine in 1824. He settled at Ripley, Ohio, where he soon acquired an extensive practice, and April 10, 1827, was united in marriage with Margaret Poage, daughter of Col. James Poage, proprietor of the town. Perhaps no man was ever more blessed with a helpmeet more adapted to his wants than this lovely, quiet, systematic, cheerful, Christian wife, who for forty-five years of perfect harmony encouraged him in his labors.

They thought themselves happily settled for life in their pleasant home, but God had better things in store for them. His Spirit began whispering in their ears the Macedonian cry. At first, they excused themselves on account of their little ones. They felt they could not take them among the Indians, that they owed a duty to them. They hesitated. God removed this obstacle in his own way—by taking the little ones home to himself. As this was a great trial, so was it a great blessing to these parents. This was one of God’s means of so strengthening their faith that, having once decided to go, neither of them ever after for one moment regretted the decision, doubted that they were called of God to this work, or feared that their life-work would prove a failure.

In the spring of 1833, Dr. Williamson placed himself under the care of the Chillicothe Presbytery, and commenced the study of theology. In August of that year he removed with his family to Walnut Hills, and connected himself with Lane Seminary. In April, 1834, in the First Presbyterian Church of Red Oak, he was licensed to preach by the Chillicothe Presbytery.

Previous to his licensure, he had received from the American Board an appointment to proceed on an exploring tour among the Indians of the Upper Mississippi, with special reference to the Sacs and Foxes, but to collect what information he could in regard to the Sioux, Winnebagoes, and other Indians. Starting on this tour about the last of April, he went as far as Fort Snelling, and returned to Ohio in August. At Rock Island he met with some of the Sacs and Foxes, and at Prairie du Chien he first saw Dakotas, among others Mr. Joseph Renville of Lac-qui-parle. On the 18th of September he was ordained as a missionary by the Chillicothe Presbytery, in Union Church, Ross County, Ohio.

A few months afterward he received his appointment as a missionary of the A. B. C. F. M. to the Dakotas; and on the first day of April, 1835, Dr. Williamson, with his wife and one child, accompanied by Miss Sarah Poage, Mrs. Williamson’s sister, who afterward became Mrs. Gideon H. Pond, and Alexander G. Huggins and family, left Ripley, Ohio, and on the 16th of May they arrived at Fort Snelling. At this time, the only white people in Minnesota, then a part of the North-west Territory, were those connected with the military post at Fort Snelling, the only post-office within the present limits of the State; those connected with the fur-trade, except Hon. H. H. Sibley, were chiefly Canadian French, ignorant of the English language; and Messrs. Gideon H. and Samuel W. Pond, who came on their own account as lay teachers of Christ to the Indians in 1834.

While stopping there for a few weeks, Dr. Williamson presided at the organization, on the 12th of June, of the First Presbyterian Church—the first Christian church organized within the present limits of Minnesota. This was within the garrison at Fort Snelling, and consisted of twenty-two members, chiefly the result of the labors of Major Loomis among the soldiers.

Having concluded to accompany Mr. Joseph Renville, Dr. Williamson’s party embarked on the fur company’s Mackinaw boat on the 22d of June; reached Traverse des Sioux on the 30th, where they took wagons and arrived at Lac-qui-parle on the 9th of July. There, on the north side of the Minnesota River, and in sight of the “Lake that speaks,” they established themselves as teachers of the religion of Jesus.