The hydrochloric acid and the pepsin cause the principal chemical changes in the food while in the stomach, acting alone upon the proteins. The only digestion of starches in the stomach is that continued by the saliva. The salivary digestion proceeds until the gastric juice is secreted in sufficient quantity to cause a marked acidity of the stomach contents, when the starches are passed into the intestines.

Gastric juice begins to flow into the stomach soon after eating, but it is not secreted in sufficient quantity to supersede salivary digestion for from twenty to forty-five minutes.

The result of gastric digestion of proteins is their conversion, first, into albumin, then into proteosis and, lastly, into peptone, which is protein in a more simple, soluble, and diffusible form. In the form of peptone, the proteins are in condition to be absorbed.

If the food has been properly cooked and masticated the gastric digestion will be completed in one and one-half to three hours. If not properly cooked and masticated, the stomach digestion may continue one to two hours longer. It should, however, be completed in three hours.

The most readily digested animal foods remain less time in the stomach. Meat, as a rule, is easily digested, because the action of the digestive juices of the animal has converted the starches and sugars. The white meat of chicken, being soft, is digested in a shorter time than the red or the dark meat.

Fluids leave the stomach more rapidly than solids. Seven ounces of water leave the stomach in one and one-half hours, seven ounces of boiled milk in about two hours.

The flow of gastric juice, as the flow of saliva, is governed by the nerves;—the sight, taste, and smell of food, and the attitude of mind toward it, to a certain extent, regulates its flow.

After the food has extensively accumulated, during the progress of a meal, the stomach begins a series of wave-like movements called peristaltic waves.[4] These waves work downward through the length of the stomach towards its lower opening, known as the pyloric orifice. As the food is moved down the stomach by these motions, it is thoroughly mixed with the gastric juice.

During the early stages of digestion, the sphincter muscles of the pylorus keep the lower end of the stomach closed, but, as digestion progresses, the pylorus gradually relaxes to let the digested, soluble portion of the food pass into the intestine. If the food still remains in a solid form, by reason of being improperly cooked or poorly masticated, as it touches the pylorus, these sphincter muscles, almost as if they were endowed with reasoning faculties, close, forcing the undigested mass back to be further acted upon by the gastric juice,—the solid mass is not allowed to pass until dissolved.

If the individual continues to abuse the stomach and to cause it to work overtime, it becomes exhausted and demands rest; it refuses to discharge the gastric juice in proper proportion; the peristaltic movements are weak; and food is not promptly or forcefully moved along the stomach and mixed with the gastric juice. This demand for a rest is termed Indigestion.