Coffee is contraindicated in hysterical and nervous persons, in children and in those who suffer with insomnia or palpitation. It counteracts sleep and coma, being very useful in poisoning by opium or its alkaloids. Its stimulant action is as rapid as that of alcohol. On several occasions it has yielded me marked results when given by stomach or by enema in cases of nervous and cardiac depression. Indeed it is a remedy that I cannot recommend too highly and each day leaves me more convinced of its therapeutic activity and certainty.
Attention has only lately been directed to the antiseptic property of coffee though we have long been availing ourselves of that property without knowing it; this is true of many other medicinal agents, indeed of all that the modern studies of bacteriology have presented to us as antifermentives and microbicides. Roasted coffee in powder form gives good results if dusted over ulcers and gangrenous sores, rapidly improving their appearance and destroying the fœtid odor. It corrects the unhygienic properties of non-potable water and therefore enters into the army and navy ration of nearly all the nations of Europe. In epidemics of disease every physician should advise its use in mild infusion as a regular beverage.
Dr. Luderitz, experimenting in the Hygienic Institute of Berlin, reported that no bacteria could resist the action of coffee in infusion. He attributed this action not only to the tannin, which is present in high percentage, but principally to the empyreumatic substances formed by the roasting. The caffeine takes no part in this action. Dr. Luderitz exposed the coffee to the open air for six days and found it free from bacteria at the end of that time. Whatever may be the explanation of its activity the fact remains that coffee is highly antiseptic, and this should be kept in mind by physicians not only because it is everywhere easily obtained and an infusion easily prepared, but because it in addition possesses the great advantage of being nontoxic.
The chemical analysis of the seed is as follows:
| Cellulose | 34.000 |
| Water | 12.000 |
| Fatty matters | 10 to 13.000 |
| Glucose, dextrin, undetermined acid | 15.500 |
| Legumin, caffeine | 10.000 |
| Chlorogenate of caffeine and potassa | 3.500 to 5.000 |
| Albuminoids | 3.000 |
| Caffeine, free | .800 |
| Essential oil, solid | .001 |
| Essential oil, liquid | .002 |
| Mineral substances | 6.697 |
Caffeine, the only one of the ingredients that interests us, was discovered by Hunge in 1821 and recognized as an alkaloid by Herzog. It also exists in tea, formerly known as “theine” which is now known to be identical with caffeine; both are expressed by the formula C8H10N2O2+H2O. It crystallizes in fine, silky needles, is colorless, odorless and slightly bitter.
It is considered a substitute for digitalis, especially valuable as a diuretic and where cerebral anemia exists. Germain See values it as a preventive medicine, acting principally upon the heart and thus preventing fatigue; with this end in view he advises its use before long marches, violent exercise and all conditions where the heart will be called upon to do a greatly increased amount of work. Dose 0.25 gram to 1 or 2 grams a day given by stomach or hypodermic injection.
Caffeine is also useful in headache, neuralgia, and asthma and as a general tonic. For the latter action it is best given in pill form, 0.02–0.04 gram a day, with the extract of cinchona or other bitter tonic.
“Etoxy-caffeine,” which is caffeine in which an atom of H has been replaced by the C2H5O, exists as white, needle-like crystals, slightly soluble in water; it is narcotic and sedative to the cerebro-spinal system. In doses of 0.24 gram it is useful in headache.
Botanical Description.—“A small tree that reaches a height of 8–9°. It grows readily in the province of Batangas without cultivation,” Blanco.