Duncan claims to have isolated from the bark an active principle which he called mudarin from “mudar,” the Indian name of the plant. Following the same process Flückiger was unable to obtain the substance, but did isolate 1½% of an acrid resin, soluble in ether and in alcohol; a mucilage and a bitter principle decolorized by chloroform and ether. It is probable that this is the active principle of the “Calotropis gigantea.”
Warden and Waddell in 1881 isolated a substance crystallizable in nodular masses, with the formula C17H28O, analogous to the albana of gutta-percha.
Botanical Description.—A small tree, 7–8° high, with straight stem, branched and woody. Leaves sessile, opposite, cleft at the base, oval, fleshy and woolly. Flowers lateral in simple umbels of 3 or more flowerets. Calyx 5-cleft. Corolla monopetalous, 5 acute lobes, white, of rare and beautiful form. Nectaries 5, united throughout their length with the receptacle, their bases curved like the sides of the fleur de lis.
Above the nectaries is a 5-angled crown, the extremity of the receptacle; in each angle a black anther. Two large follicles narrowed at the ends, woolly, the apex somewhat curved to one side, containing many imbricated seeds, each with a tuft of long hairs.
Habitat.—Bauang, Taal and the volcanic island of Taal. Blossoms in April.
Tylophora asthmatica, Wight. (Asclepias asthmatica, Roxb.)
Nom. Vulg.—(?)
Uses.—We are ignorant of the uses the Filipinos make of this plant. It is official in the Pharmacopœia of India, the dry powdered leaf being the part employed, and its emetic, diaphoretic and expectorant properties are well known in that country. Roxburgh has used the root as an emetic and Anderson has employed it in the same manner as ipecac in dysentery. Later the experience of Anderson was confirmed by O’Shaughnessy; though in place of the root he used the leaf, the properties of which he regards as more certain and uniform.
Dr. J. Kirkpatrick has noted that the juice of the root and its powder are used by the natives of Mysore as an emetic, and adds that he himself has used it for that purpose in a thousand cases with good results. In its effect on dysentery as well as in its emetic effect it resembles ipecacuanha. He used the powder in doses of 1.20–1.80 gr., to which he added 3–6 centigrams of tartar emetic when he desired to obtain an energetic emetic action. Like O’Shaughnessy he prefers the powdered leaves. He considers it a good substitute for ipecac, not only as an emetic, but as a remedy in asthma, dysentery and catarrhal affections; Drs. Oswald and Mooden Sheriff have made the same observations. The latter advises the administration of the juice of the plant for snake bites till vomiting is produced; then follow with diffusible stimulants.
The emetic dose of the powdered leaves is 1.20–1.80 grams, the expectorant and diaphoretic dose 10–30 centigrams. The concentrated infusion of the leaves has an acrid taste. Tannic acid, the neutral acetate of lead and caustic potash produce with it an abundant precipitate; the perchloride of iron colors it a dark green. Broughton, of Ootaemund (India), informed Hanbury and Flückiger, from whom we quote, that in 1872 he obtained a very small quantity of crystals from a large quantity of leaves. He had not enough to make an analysis, but injected a solution of the crystals into a dog with resulting vomiting and diarrhœa.