24th. Gone abroad for his pleasure.
25th. He called on me; and the pustules having advanced properly towards maturation, I ordered him immediately to the house, where he remained perfectly well, and the pustules, which were about twenty, maturated very kindly.
27th. He took a purgative, which operated moderately. On the 28th he returned home in good health, and has continued so ever since.
CASE XI.
Two men were inoculated at the same time, the one about 40 years of age, corpulent, and subject to the rheumatism; the other between 50 and 60, very thin and healthy.
I saw both these patients on the third day, when the places of insertion were in each so very much inflamed, that I was pretty certain they would scarce have any eruption, and acquainted them with my opinion. Both made complaints of itching and uneasiness in the part; there was however this difference, the elder said he had felt a numbness and smarting from the time of inoculation, particularly the following night; that his head had been in pain, and that he had had several chilly fits: the other complained that his arms felt hot, and itched, but said he was very well. They both came to me on the sixth day, when the inflammation on the arm of the elder was considerably abated; and he said that from the time that I saw him last, he had remained free from any complaint, except a slight uneasiness at the parts infected. The incisions of the other were still in an inflamed state; he said that his head had ached, and that he was very chilly the preceding night: both these symptoms continued for two days more; but the attacks were irregular, lasted but a very short time, and there was not the least appearance of fever. The other held perfectly well, and all signs of inflammation on the arms of both soon disappeared.
They both remained several days in the same house, and kept company with others in different stages of the disease; the elder of the two was inoculated again, but without the least signs of the infection taking place, and both remain in good health.
CASE XII.
A gentlewoman turned of 50, of a corpulent habit and clear complexion, was inoculated about noon. On the following morning she informed me that the inoculated parts, and more especially one arm, had smarted very much, and felt benumbed up to the shoulder, and had been sufficiently troublesome to disturb her rest: upon inspecting the parts, they were found much inflamed, and a little elevated. These kinds of feelings were complained of that whole day, and towards night her head ached; but she had no increase of heat, or alteration in the pulse. On the third morning there was a flushing on the skin round the puncture on each arm, nearly the breadth of a sixpence; on applying the finger, it felt hard about the middle; and upon the whole, the appearances of infection were as evident as are usually observable on the 9th or 10th day. I therefore ventured to assure her, that the disease would pass over in a very slight manner, and most probably without any eruption; and the event justified my prognostic.