Most of the muscles act upon the bones, so as to produce the effects of a lever of the third kind, as it is termed by mechanics, where the power acts between the centre of motion and the weight; hence it has a mechanical disadvantage; as an instance of this, the muscle which bends the forearm, is inserted about one eighth or one tenth of the distance from the centre of motion that the hand is, where the weight or resistance is applied; hence the muscle must exert a force eight or ten times greater than the weight to be raised. But this disadvantage is amply compensated by making the limbs move with greater velocity; besides, if room had been given for the muscles to act with greater advantage, the limbs must have been exceedingly deformed and unwieldy. [1]

The muscles, in general, at least those which serve for voluntary motion, are balanced by antagonists, by means of which they are kept beyond their natural stretch. When one of two antagonists is contracted by the will, the other relaxes in order to give it play; or at least becomes overpowered by the contraction of the first. Also when one of such muscles happens to be paralytic, the other being no longer balanced, or kept on the stretch, immediately contracts to its natural length, and remains in that situation. The part to which it is fixed will, of course, be affected accordingly. If one of the muscles which move the mouth sideways be destroyed, the other immediately contracting, draws the mouth awry; and in that situation it remains. The same may be observed of the leg, the arm, and other parts. Some muscles assist one another in their action, while others have different actions; according to their shapes, the course of their fibres, and the structure of the parts they move.

According to the shape and nature of the bones to be moved, and of the motions to be performed, the muscles are either long, or short; slender, or bulky; straight, or round. Where a great motion is required, as in the leg, or arm, the muscles are long; where a small motion is necessary, they are short; for a strong motion they are thick, and for a weak one slender.

Some of the muscles are fastened to, and move bones; others cartilages, and others again other muscles, as may best suit the intention to be answered.

With respect to the bones, some are solid and flattened; others hollow and cylindrical. Every cylindrical bone is hollow, or has a cavity containing a great number of cells, filled with an oily marrow. Each of these cells is lined with a fine membrane, which forms the marrow. On this membrane, the blood vessels are spread, which enter the bones obliquely, and generally near their middle; from some branches of these vessels the marrow is secreted; while others enter the internal substance of the bones for their nourishment; and the reason why they enter the bones obliquely is, that they may not weaken them by dividing too many fibres in the same place.

The bones being made hollow, their strength is greatly increased without any addition to their weight; for if they had been formed of the same quantity of matter without any cavities, they would have been much weaker; their strength to resist breaking transversely being proportionate to their diameters, as is evident from mechanics.

All the bones, excepting so much of the teeth as are out of the sockets, and those parts of other bones which are covered with cartilages, are surrounded by a fine membrane, which on the skull is called pericranium, but in other parts periosteum. This membrane serves for the muscles to slide easily upon, and to hinder them from being lacerated by the hardness and roughness of the bones.

But though the apparatus which I have been describing is admirably contrived for the performance of motion; it would continue for ever inactive, if not animated by the nervous system.

The brain is the seat of the intelligent principle: from this organ, white, soft, and medullary threads, called nerves, are sent off to different parts of the body: some of them proceed immediately from the brain to their destined places, while the greater number, united together, perforate the skull, and enter the cavity of the backbone, forming what we call the spinal marrow, which may be regarded as a continuation of the brain. Portions of the spinal marrow pass through different apertures to all parts of the body.

We are not conscious of the impression of external objects on our body, unless there be a free communication of nerves, between the place where the impression is made and the brain. If a nerve be divided, or have a ligature put round it, sensation is intercepted.