Dr. Girtanner injected a quantity of very pure oxygen gas into the jugular vein of a dog: the animal raised terrible outcries, breathed very quickly, and with great difficulty: by little and little his limbs became hard and stiff, he fell asleep, and died in the course of a few minutes afterwards. It ought here to be observed, that any of the gases, or almost any fluid, however mild, when thus suddenly introduced into the circulating system, generally, and speedily, occasions death.
On opening the chest, the heart was found more irritable than ordinary, and its external contractions and dilatations continued for more than an hour: the right auricle of the heart, which usually contains black venous blood, contained, as well as the right ventricle, a quantity of blood of a bright vermilion colour; and all the muscles of the body were found to be more than usually irritable. This experiment not only proves that the vermilion colour of the blood proceeds from oxygen, but likewise seems to show, that oxygen is the cause of excitability.
A quantity of azotic gas, which had been exposed for some time to the contact of lime water, in order to separate any carbonic acid gas it might contain, was injected into the jugular vein of a dog. The animal died in twenty seconds. Upon opening the chest, the heart was found filled with black and coagulated blood: this organ, and most of the muscles had nearly lost the whole of their irritability, for they contracted but very weakly, on the application of the strongest stimulants.
A quantity of carbonic acid gas was injected into the jugular vein of a dog: the animal became sleepy, and died in about a quarter of an hour: the heart was found filled with black and coagulated blood, and had lost the whole of its irritability; neither it, nor any of the muscles producing any contractions, upon the application of stimulants.
Humboldt likewise mentions a curious fact, which tends strongly to confirm this idea. When the excitability of the limb of a frog had been so far exhausted, by the application of zinc and silver, that it would produce no more contractions, on moistening it with oxygenated muriatic acid, the contractions were renewed.
After the excitability of the sensitive plant (mimosa pudica) had been so far exhausted, by irritation, that it ceased to contract, when further irritated, I restored this excitability, and brought it to a very high degree of irritability, by moistening the earth in which it grew with oxygenated muriatic acid. Seeds likewise vegetate more quickly when moistened with this acid, than when they are not.
In short, we shall find, first, that every thing which increases the quantity of oxygen in organized bodies, increases at the same time their excitability.
Secondly, That whatever diminishes the quantity of oxygen, diminishes the excitability.
The excitability of animals, made to breathe oxygen gas, or to take the oxygenated muriate of potash, or acid fruits, is very much increased.
On the contrary, when persons have inspired carbonic acid, or azotic gas, or have taken into the system substances which have a strong affinity for oxygen, and therefore tend to abstract it, such as hydrogen, and spirits, the excitability becomes very much diminished.