In order to show that they were sincere in their professions of interest in the spiritual welfare of the Indians, the Company determined to erect a college at Henrico "for the training up of the children of those Infidels in true Religion, moral virtue and civility".[157] The clergy of England were enthusiastic in their support of this good design, and their efforts resulted in liberal contributions from various parts of the kingdom.[158] Unfortunately, however, the money thus secured was expended in sending to the college lands a number of "tenants" the income from whose labor was to be utilized in establishing and supporting the institution.[159] As some of these settlers fell victims to disease and many others were destroyed in the massacre of 1622, the undertaking had to be abandoned, and of course all thought of converting and civilizing the savages was given up during the long and relentless war that ensued.

Even more discouraging than these failures was the hostility of the King to the cultivation of tobacco in Virginia, and his restrictions upon its importation into England. Appeals were made to him to prohibit the sale of Spanish tobacco, in order that the Virginia planters might dispose of their product at a greater profit. This, it was argued, would be the most effective way of rendering the colony prosperous and self sustaining. But James, who was still bent upon maintaining his Spanish policy, would not offend Philip by excluding his tobacco from England. Moreover, in 1621, he issued a proclamation restricting the importation of the leaf from Virginia and the Somers Isles to fifty-five thousand pounds annually.[160] This measure created consternation in Virginia and in the London Company. The great damage it would cause to the colony and the diminution in the royal revenue that would result were pointed out to James, but for the time he was obdurate.[161] Indeed, he caused additional distress by granting the customs upon tobacco to a small association of farmers of the revenue, who greatly damaged the interests of the colony. In 1622, James, realizing that his policy in regard to tobacco was injuring the exchequer, made a compromise with the Company. The King agreed to restrict the importation of Spanish tobacco to 60,000 pounds a year, and after two years to exclude it entirely. All the Virginia leaf was to be admitted, but the Crown was to receive one third of the crop, while the other two thirds was subjected to a duty of six pence a pound.[162] This agreement proved most injurious to the Company, and it was soon abandoned, but the heavy exactions of the King continued. Undoubtedly this unwise policy was most detrimental to Virginia. Not only did it diminish the returns of the Company and make it impossible for Sandys to perfect all his wise plans for the colony, but it put a decided check upon immigration. Many that would have gone to Virginia to share in the profits of the planters, remained at home when they saw that these profits were being confiscated by the King.[163]

Yet the strenuous efforts of the London Company would surely have brought something like prosperity to the colony had not an old enemy returned to cause the destruction of hundreds of the settlers. This was the sickness. For some years the mortality had been very low, because the old planters were acclimated, and few new immigrants were coming to Virginia. But with the stream of laborers and artisans that the Sandys régime now sent over, the scourge appeared again with redoubled fury. As early as January, 1620, Governor Yeardley wrote "of the great mortallitie which hath been in Virginia, about 300 of ye inhabitants having dyed this year".[164] The sickness was most deadly in the newly settled parts of the colony, "to the consumption of divers Hundreds, and almost the utter destruction of some particular Plantations".[165] The London Company, distressed at the loss of so many men, saw in their misfortunes the hand of God, and wrote urging "the more carefull observations of his holy laws to work a reconciliation".[166] They also sent directions for the construction, in different parts of the colony, of four guest houses, or hospitals, for the lodging and entertaining of fifty persons each, upon their first arrival.[167] But all efforts to check the scourge proved fruitless. In the year ending March, 1621 over a thousand persons died upon the immigrant vessels and in Virginia.[168] Despite the fact that hundreds of settlers came to the colony during this year, the population actually declined. In 1621 the percentage of mortality was not so large, but the actual number of deaths increased. During the months from March, 1621, to March, 1622, nearly twelve hundred persons perished. It was like condemning a man to death to send him to the colony. Seventy-five or eighty per cent. of the laborers that left England in search of new homes across the Atlantic died before the expiration of their first year. The exact number of deaths in 1622 is not known, but there is reason to believe that it approximated thirteen hundred.[169] Mr. George Sandys, brother of the Secretary of the London Company, wrote, "Such a pestilent fever rageth this winter amongst us: never knowne before in Virginia, by the infected people that came over in ye Abigall, who were poisoned with ... beer and all falling sick & many dying, every where dispersed the contagion, and the forerunning Summer hath been also deadly upon us."[170] Not until 1624 did the mortality decline. Then it was that the Governor wrote, "This summer, God be thanked, the Colony hath very well stood to health".[171] The dread sickness had spent itself for lack of new victims, for the immigration had declined and the old planters had become "seasoned".

History does not record an epidemic more deadly than that which swept over Virginia during these years. It is estimated that the number of those that lost their lives from the diseases native to the colony and to those brought in from the infected ships amounts to no less than four thousand.[172] When the tide of immigration was started by Sir Edwin Sandys in 1619, there were living in Virginia about nine hundred persons; when it slackened in 1624 the population was but eleven hundred. The sending of nearly five thousand settlers to Virginia had resulted in a gain of but two hundred. It is true that the tomahawk and starvation accounts for a part of this mortality, but by far the larger number of deaths was due to disease.

Yet hardly less horrible than the sickness was the Indian massacre of 1622. This disaster, which cost the lives of several hundred persons, struck terror into the hearts of every Englishman in Virginia. The colonists had not the least intimation that the savages meditated harm to them, for peace had existed between the races ever since the marriage of Rolfe and Pocahontas. Considering the protection of their palisades no longer necessary after that event, they had spread out over the colony in search of the most fertile lands. Their plantations extended at intervals for many miles along both banks of the James, and in the case of a sudden attack by the Indians it would obviously be difficult for the settlers to defend themselves or to offer assistance to their neighbors.

The apparent friendship of the Indians had created such great intimacy between the two races, that the savages were received into the homes of the white men and at times were fed at their tables.[173] At the command of the London Company itself some of the Indian youths had been adopted by the settlers and were being educated in the Christian faith. So unsuspecting were the people that they loaned the savages their boats, as they passed backward and forward, to formulate their plans for the massacre.[174]

The plot seems to have originated in the cunning brain of Opechancanough. This chief, always hostile to the white men, must have viewed with apprehension their encroachment upon the lands of his people. He could but realize that some day the swarms of foreigners that were arriving each year would exclude the Indians from the country of their forefathers. Perceiving his opportunity in the foolish security of the English and in their exposed situation, he determined to annihilate them in one general butchery.

His plans were laid with great cunning. Although thousands of natives knew of the design, no warning reached the white men until the very eve of the massacre. While Opechancanough was preparing this tremendous blow, he protested in the strongest terms his perpetual good will and love, declaring that the sky would fall before he would bring an end to the peace.[175] In order to lull the suspicions of the planters, "even but two daies before the massacre", he guided some of them "with much kindnesse through the woods, and one Browne that lived among them to learne the language", he sent home to his master. The evening before the attack the Indians came as usual to the plantations with deer, turkeys, fish, fruits and other provisions to sell.[176]

That night, however, a warning was received, which although too late to save the most remote settlements, preserved many hundreds from the tomahawk. Chanco, an Indian boy who had been adopted by an Englishman named Race, revealed the entire plot to his master. The man secured his house, and rowed away before dawn in desperate haste to Jamestown, to give warning to the Governor. "Whereby they were prevented, and at such other plantations as possibly intelligence could be given."[177]

The assault of the savages was swift and deadly. In all parts of the colony they fell upon the settlers, and those that had received no warning were, in most cases, butchered before they could suspect that harm was intended. Sometimes the Indians sat down to breakfast with their victims, "whom immediately with their owne tooles they slew most barbarously, not sparing either age or sex, man woman or childe".[178] Many were slain while working in the fields; others were trapped in their houses and butchered before they could seize their weapons. The savages, "not being content with their lives,... fell againe upon the dead bodies, making as well as they could a fresh murder, defacing, dragging, and mangling their dead carkases into many peeces".[179]