In Paris he had not a single acquaintance, nor did he bring with him a single introductory letter; but understanding that M. Tronchin, at that time a distinguished medical practitioner in Paris, was a native of Geneva, he thought he might consider him as in some measure a countryman. On this slender ground he waited on M. Tronchin, and what is rather surprising, and reflects great credit on both, this acquaintance, begun in so uncommon a way, soon ripened into friendship. Tronchin interested himself for his young protégée, and soon got him into the situation of physician in ordinary to the Duke of Orleans, father of him who cut so conspicuous a figure in the French revolution, under the name of M. Egalité. In this situation he devoted himself to the study of chemistry, and soon made himself known by his publications on the subject.

In 1781 he was elected a member of the Academy of Sciences of Paris: one of his competitors was M. Fourcroy. No doubt Berthollet owed his election to the influence of the Duke of Orleans. In the year 1784 he was again a competitor with M. de Fourcroy for the chemical chair at the Jardin du Roi, left vacant by the death of Macquer. The chair was in the gift of M. Buffon, whose vanity is said to have been piqued because the Duke of Orleans, who supported Berthollet's interest, did not pay him sufficient court. This induced him to give the chair to Fourcroy; and the choice was a fortunate one, as his uncommon vivacity and rapid elocution particularly fitted him for addressing a Parisian audience. The chemistry-class at the Jardin du Roi immediately became celebrated, and attracted immense crowds of admiring auditors.

But the influence of the Duke of Orleans was sufficient to procure for Berthollet another situation which Macquer had held. This was government commissary and superintendent of the dyeing processes. It was this situation which naturally turned his attention to the phenomena of dyeing, and occasioned afterwards his book on dyeing; which at the time of its publication was excellent, and exhibited a much better theory of dyeing, and a better account of the practical part of the art than any work which had previously appeared. The arts of dyeing and calico-printing have been very much improved since the time that Berthollet's book was written; yet if we except Bancroft's work on the permanent colours, nothing very important has been published on the subject since that period. We are at present almost as much in want of a good work on dyeing as we were when Berthollet's book appeared.

In the year 1785 Berthollet, at a meeting of the Academy of Sciences, informed that learned body that he had become a convert to the antiphlogistic doctrines of Lavoisier. There was one point, however, upon which he entertained a different opinion from Lavoisier, and this difference of opinion continued to the last. Berthollet did not consider oxygen as the acidifying principle. On the contrary, he was of opinion that acids existed which contained no oxygen whatever. As an example, he mentioned sulphuretted hydrogen, which possessed the properties of an acid, reddening vegetable blues, and combining with and neutralizing bases, and yet it was a compound of sulphur and hydrogen, and contained no oxygen whatever. It is now admitted that Berthollet was accurate in his opinion, and that oxygen is not of itself an acidifying principle.

Berthollet continued in the uninterrupted prosecution of his studies, and had raised himself a very high reputation when the French revolution burst upon the world in all its magnificence. It is not our business here to enter into any historical details, but merely to remind the reader that all the great powers of Europe combined to attack France, assisted by a formidable army of French emigrants assembled at Coblentz. The Austrian and Prussian armies hemmed her in by land, while the British fleets surrounded her by sea, and thus shut her out from all communication with other nations. Thus France was thrown at once upon her own resources. She had been in the habit of importing her saltpetre, and her iron, and many other necessary implements of war: these supplies were suddenly withdrawn; and it was expected that France, thus deprived of all her resources, would be obliged to submit to any terms imposed upon her by her adversaries. At this time she summoned her men of science to her assistance, and the call was speedily answered. Berthollet and Monge were particularly active, and saved the French nation from destruction by their activity, intelligence, and zeal. Berthollet traversed France from one extremity to the other; pointed out the mode of extracting saltpetre from the soil, and of purifying it. Saltpetre-works were instantly established in every part of France, and gunpowder made of it in prodigious quantity, and with incredible activity. Berthollet even attempted to manufacture a new species of gunpowder still more powerful than the old, by substituting chlorate of potash for saltpetre: but it was found too formidable a substance to be made with safety.

The demand for cannon, muskets, sabres, &c., was equally urgent and equally difficult to be supplied. A committee of men of science, of which Berthollet and Monge were the leading members, was established, and by them the mode of smelting iron, and of converting it into steel, was instantly communicated, and numerous manufactories of these indispensable articles rose like magic in every part of France.

This was the most important period of the life of Berthollet. It was in all probability his zeal, activity, sagacity, and honesty, which saved France from being overrun by foreign troops. But perhaps the moral conduct of Berthollet was not less conspicuous than his other qualities. During the reign of terror, a short time before the 9th Thermidor, when it was the system to raise up pretended plots, to give pretexts for putting to death those that were obnoxious to Robespierre and his friends, a hasty notice was given at a sitting of the Committee of Public Safety, that a conspiracy had just been discovered to destroy the soldiers, by poisoning the brandy which was just going to be served out to them previous to an engagement. It was said that the sick in the hospitals who had tasted this brandy, all perished in consequence of it. Immediate orders were issued to arrest those previously marked for execution. A quantity of the brandy was sent to Berthollet to be examined. He was informed, at the same time, that Robespierre wanted a conspiracy to be established, and all knew that opposition to his will was certain destruction. Having finished his analysis, Berthollet drew up his results in a Report, which he accompanied with a written explanation of his views; and he there stated, in the plainest language, that nothing poisonous was mixed with the brandy, but that it had been diluted with water holding small particles of slate in suspension, an ingredient which filtration would remove. This report deranged the plans of the Committee of Public Safety. They sent for the author, to convince him of the inaccuracy of his analysis, and to persuade him to alter its results. Finding that he remained unshaken in his opinion, Robespierre exclaimed, "What, Sir! darest thou affirm that the muddy brandy is free from poison?" Berthollet immediately filtered a glass of it in his presence, and drank it off. "Thou art daring, Sir, to drink that liquor," exclaimed the ferocious president of the committee. "I dared much more," replied Berthollet, "when I signed my name to that Report." There can be no doubt that he would have paid the penalty of this undaunted honesty with his life, but that fortunately the Committee of Public Safety could not at that time dispense with his services.

In the year 1792 Berthollet was named one of the commissioners of the Mint, into the processes of which he introduced considerable improvements. In 1794 he was appointed a member of the Commission of Agriculture and the Arts: and in the course of the same year he was chosen professor of chemistry at the Polytechnic School and also in the Normal School. But his turn of mind did not fit him for a public teacher. He expected too much information to be possessed by his hearers, and did not, therefore, dwell sufficiently upon the elementary details. His pupils were not able to follow his metaphysical disquisitions on subjects totally new to them; hence, instead of inspiring them with a love for chemistry, he filled them with langour and disgust.

In 1795, at the organization of the Institute, which was intended to include all men of talent or celebrity in France, we find Berthollet taking a most active lead; and the records of the Institute afford abundant evidence of the perseverance and assiduity with which he laboured for its interests. Of the committees to which all original memoirs are in the first place referred, we find Berthollet, oftener than any other person, a member, and his signature to the report of each work stands generally first.

In the year 1796, after the subjugation of Italy by Bonaparte, Berthollet and Monge were selected by the Directory to proceed to that country, in order to select those works of science and art with which the Louvre was to be filled and adorned. While engaged in the prosecution of that duty, they became acquainted with the victorious general. He easily saw the importance of their friendship, and therefore cultivated it with care; and was happy afterwards to possess them, along with nearly a hundred other philosophers, as his companions in his celebrated expedition to Egypt, expecting no doubt an eclat from such a halo of surrounding science, as might favour the development of his schemes of future greatness. On this expedition, which promised so favourably for the French nation, and which was intended to inflict a mortal stab upon the commercial greatness of Great Britain, Bonaparte set out in the year 1798, accompanied by a crowd of the most eminent men of science that France could boast of. That they might co-operate more effectually in the cause of knowledge, these gentlemen formed themselves into a society, named "The Institute of Egypt," which was constituted on the same plan as the National Institute of France. Their first meeting was on the 6th Fructidor (24th of August), 1798; and after that they continued to assemble, at stated intervals. At these meetings papers were read, by the respective members, on the climate, the inhabitants, and the natural and artificial productions of the country to which they had gone. These memoirs were published in 1800, in Paris, in a single volume entitled, "Memoirs of the Institute of Egypt."