Hemorrhagic septicemia is a name applied to a highly fatal, infectious disease existing in various species of domestic and wild animals, from a microorganism having definite biological characters and possessing the properties of producing clearly defined and characteristic lesions.
This causal agent, Bacterium bovisepticum, belongs to the same group of cocco-bacilli as those causing chicken cholera, swine plague, and rabbit septicemia, and may be described as an ovoid, nonmotile, polar-staining bacterium with rounded ends, 1/38000 of an inch wide by 1/20000 of an inch long, sometimes seen in pairs and sometimes in chains.
Various names have been applied to this disease, and though the causative agent and the distinctive lesions are well known, it is more than likely that the affection is seldom recognized. It was described by Bollinger in 1878, and named Wild und Rinderseuche, from its having affected deer, wild boars, cattle, and horses in an epizootic which swept over Germany at that time. Before this, however, several epizootics of what was evidently the same disease had been well described, notably that which occurred in England in 1854. Since then it has occurred in epizootic and enzootic forms in many sections of Europe, Asia, Africa, and America. In this country the disease has been observed in Texas, Tennessee, New York, Minnesota, Pennsylvania, District of Columbia, South Dakota, and Wisconsin. Other names given to it are game and cattle disease, buffalo disease, barbone, pasteurellosis bovina, ghotwa, and infectious pneumoenteritis.
In earlier times it was evidently confounded with gloss anthrax, and even now it is probably mistaken in a great many instances for anthrax, blackleg, cornstalk disease, and cerebrospinal meningitis.
The disease is essentially a septicemia, or blood poisoning, and the microbic invasion occurs from inoculation probably either through abrasions of the skin or by injury to the mucous membranes from coarse fodder, etc. Moore and Smith have found in the mouths and nasal cavities of healthy animals, including cattle, bacteria belonging to this group; but these organisms proved to be nonpathogenic. As is well known, however, many pathogenic germs at times exist in a saprophytic state, and it is not hard to conceive how a microbe may cease such existence and assume parasitic or pathogenic properties when the surroundings are eminently favorable. This may be a connecting link in the etiology of sporadic outbreaks of the disease in which all other hypotheses as to its genesis seem untenable. The disease seems to occur most frequently in swampy or mucky localities or in pastures receiving the overflow from infected fields. It is said to occur usually in the spring of the year, when the melting snows and rains bring to the surface the subterranean waters from rich soils containing nitrogenous materials in which the bacteria have been existing. In a great many instances there does not seem to be any plausible explanation for an outbreak of the disease and one can only surmise as to its origin.
Symptoms.—Three forms of the disease are recognized, based upon the distribution of the lesions—the superficial, or cutaneous, the pectoral, or thoracic, and the intestinal form. The last is a usual accompaniment of the other two and may be mild or severe. Naturally the symptoms vary according to the violence of the attack and to the particular form of disease with which the animal is affected. In the superficial, or cutaneous, form the presence of a swollen tongue, throat, and dewlap, or even of the lower portion of the legs, gives us a clew to the trouble. An entire loss of appetite occurs, and in milk cows there is a diminution of the milk secretion. The temperature may be only slightly elevated, but it is usually very high. Salivation is set up by the inflammation of the mouth and pharynx. Unsuccessful efforts at eating and swallowing are made. There may be difficulty in breathing, depending on the amount of involvement of the larynx, trachea, bronchi, or lungs. There may be a blood-stained discharge from the nostrils, and the mucous membrane thereof will often show punctiform hemorrhages. The pulmonary form shows the same symptoms as croupous pneumonia, with a frequent suffocative cough and oppressed breathing, or dyspnea. When the intestines are involved the patient strains to defecate, and passes shreds of intestinal mucus along with blood-stained feces. The urine also may be tinged with blood. Finally a severe diarrhea takes place, the animal becomes correspondingly weak, and death takes place in 24 to 36 hours. Cases may die in as short a period as six to eight hours, while in the pectoral form of the disease the animal may linger six or eight days. Cases have been reported which became chronic and in which death did not take place for a month or more. In some of the cases running an acute course, symptoms of toxemia are present; there is a lack of sensation of the skin, staggering gait, trembling, eyes fixed, neck at times bent to one side, and the eyes showing a wild expression. At times the animals appear as if in pain and look around at the flanks. In the pectoral form they may stand with the forelegs wide apart in evident effort to breathe more freely. Sometimes there is a champing of the jaws and a very free flow of glairy saliva dropping from the mouth.
The prognosis is decidedly unfavorable and 80 to 90 per cent of the cases result fatally.
Lesions.—The characteristic lesions of hemorrhagic septicemia consist of hemorrhagic areas in the subcutaneous, subserous, and muscular tissues, the lymph glands, and the viscera; in fact, they are distributed more or less widely throughout the body and vary in size from a mere speck to the diameter of a half dollar or even larger. The superficial form presents itself first as a doughy tumefaction of the skin about the region of the throat, neck, dewlap, or legs, which pits on pressure. This tumefaction consists essentially of a cerogelatinous exudate into the subcutaneous and intermuscular tissues.
Bloody extravasations may take place in subcutaneous tissues in various places, but they are usually seen about the lower portion of the neck. The mucous membranes and submucous tissues of the mouth, tongue, pharynx, and larynx become involved in the process and are greatly thickened, inflamed, and infiltrated with serum. The mucous membrane becomes reddish purple, and that of the nostrils may in addition show hemorrhagic spots on its surface. The lymphatic glands in this region are also swollen and infiltrated with bloody serum. The salivary glands are pale and dry. The pectoral type, though at times existing alone, may coexist with the cutaneous form. The inflammatory edema of the mouth extends to the mucous membrane of the trachea and bronchi, producing an extensive thickening and a yellowish infiltration. The lung shows interstitial thickening from the outpouring of serum into its meshes. It may become pneumonic.