Not surprisingly, the next people to infiltrate Big Bend were nomadic Indians adapted to desert life. Theirs was a follow-the-food economy, and they camped in caves and rock shelters close to such water sources as the Rio Grande and its tributaries, springs, and rock wells. They hunted desert animals for meat and skins, ate juniper berries, pricklypears, century plant hearts, yucca blossoms, and mesquite beans. They made baskets, nets, mats, and sandals from basketgrass and the long slim leaves of the yucca. Today, thousands of years later, remnants of these may still be found in dry caves. These prehistoric nomads also disappeared, perhaps killed or absorbed by the Jumanos, a semi-pueblo people who came to occupy the river valleys west of the park.

Cabeza de Vaca and his companions are thought to have been the first Spaniards to reach Big Bend. In 1535 they were astonished to find a farming people—probably the Jumanos at Presidio—living in actual houses at the junction of two rivers. Many years were to pass before the conquistadores scouted this far country. Driven by their lust for gold and silver and zealous to Christianize the Indians, the Spaniards ignored Big Bend because they thought this unpeopled desert held no riches. The only Indians then living in the park were the Chisos, a tribe from north central Mexico that passed its summers in the mountains north of the Rio Grande. The Spaniards had the habit of enslaving Indians to work their mines, and the Chisos retaliated by coming down from Big Bend to raid the Spaniards. In 1644 the Chisos won a great victory, but in the end, they were driven out by a new group of Indians who filtered down the Rio Grande from New Mexico. These were the Mescalero Apaches, so-called because they ate the heart of the “mescal” or century plant. So fierce and skilled in battle were they that even the Spaniards fled before them. By 1720 they dominated Big Bend, becoming known as Chisos Apaches. Regarding themselves as mountain folk, the Apaches became the most successful desert dwellers and guerrilla fighters this country has ever known. What nature did not provide they took by raiding. Belatedly the Spaniards tried to stop the raids by building forts near major Rio Grande fords. One of these, a combination mission and presidio, was built about 1770 on the Mexican side at the park’s San Vicente crossing. But the Apaches kept up the pressure, the Spaniards fled, and the fort soon lay in decay.

Strawberry pitaya cactus blossoms and articulated spines pose delicate counterpoints to sweeping desert, mountain, and canyon grandeur.

About this same time a new group of raiders, the Comanches, appeared in Big Bend. These nomadic buffalo hunters may have been the finest horsemen the world has ever seen. They ruled the south plains from Oklahoma to Texas and used Big Bend as a highroad to Mexico. For more than a hundred years, at the full of the September moon, the painted warriors crossed the Pecos and swept down past the flattopped hills and on up the long, empty, gently sloping desert floor toward the blue mountains, threading the Santiagos at Persimmon Gap where U.S. 385 now enters the park. They forded the Rio Grande at present-day Lajitas, picked Mexico clean as far south as Durango, and turned home at the end of the year. Driving captives and herds of horses and cattle northward, they probably recrossed the Rio at Paso de Chisos just to the west of Mariscal Canyon. We are told that for decades after the last Comanche left Big Bend, the great War Trail burned like a white scar across the landscape, scuffed bare by countless hooves.

Distinctive pads of pricklypear cactus make this most ubiquitous of cactuses readily recognizable across its extensive range, which encompasses Southwest deserts and the Potomac River banks near Washington, D.C.

Anglo-Americans took no interest in Big Bend until the Mexican War of 1848 fixed the border along the Rio Grande. In the 1850s, two U.S. Boundary Survey teams traveled downriver by boat and mule train, and their published reports give the first scientific look at Big Bend country and its plants and wildlife. But for the next quarter-century Big Bend belonged to the Indians, and to the U.S. troopers who pushed endless patrols across its everlasting wilderness, facing sun, thirst, alkali dust, danger, and sometimes death, for $13 a month. The Mescaleros knew the country. They knew how to use its mountains, caves, canyons, and arroyos, and where to find water, wood, grass, and game. But tracked at last into their most secret and remote retreats, nothing remained for them but the reservation. As for the Chisos Apaches, they were tricked into Mexico by a promise of asylum, only to be captured and killed or dispersed across Mexico.

Although Big Bend Indians had long used cinnabar red in their war paint and rock paintings, not until the end of the last century did commercial mining of cinnabar ore begin. To look at the ruins of Terlingua and Study Butte today, it is hard to imagine that 2,000 souls lived and worked just west of the park. Yet the Chisos Mining Company was once the world’s second largest quicksilver mine, producing 100,000 flasks of mercury between 1900 and 1941. The park’s own Mariscal Mine had a relatively short life and never really made money. All of the mines finally succumbed when the rich ore veins played out and the price of quicksilver fell. Similar fates overtook the copper, zinc, and lead mines that drew a couple thousand people to both sides of the river near present-day Boquillas. These mines were located in Mexico’s Sierra del Carmen and the ore crossed the river to the U.S. side via a steam-driven aerial tramway. Mule-drawn wagons and trucks then hauled it over the Old Ore Road to railhead at Marathon 160 kilometers (100 miles) away.