3. Shortness of breath.
4. Increase or decrease of appetite, sometimes nausea, less frequently vomiting, still less diarrhœa.
5. Improvement in body nutrition generally, more complete absorption of nitrogenous food. But later on nitrogen is excreted in excess of that taken in the food.
6. Loss of weight.
7. Increase of sexual desire.
8. Menses profuse, prolonged or more frequent, rarely amenorrhœa.
9. Increased activity of the mucous membrane, kidneys and skin, which becomes moist and oily, sometimes exfoliation of the epidermis.
10. Rapid growth of the skeleton in the young with softening and bending of those bones which have to bear weight.
11. A disease closely resembling exophthalmic goitre. A cataleptic improved under large doses of Thyroid, but when the dose of 75 grs. a day was reached symptoms like those of exophthalmic goitre developed with a pulse of 160, but no glandular swelling. When the Thyroid was discontinued the catalepsy grew worse, the exophthalmic goitre better; when resumed the catalepsy better, the exophthalmic goitre worse.
A patient, while under Thyroid treatment for myxœdema, took, through a misunderstanding, in eleven days nearly 3 ounces of the dessicated Thyroid, whereupon tachycardia, pyrexia, insomnia, tremor of the limbs, polyuria, albuminuria, and glucosuria, in short, a disease similar to exophthalmic goitre developed.