The discoverer was now set high in the estimation of mankind. Imperial Germany best of all countries rewards its benefactors. France is fascinated with adventure; Great Britain with slaughter; America with bare political battles; but Germany sees the true thing, and rewards it. Koch was immediately placed beyond want by his government, and titles and honors came without stint.
The Empire would fain have such a man at the seat of power. Dr. Koch was, in 1885, made a professor in the University of Berlin. The new chair of Hygiene was created for him, and he was made Director of the Hygienic Institute. It was in this capacity that armed with influence and authority and having the resources of the government virtually at his disposal, he directed in the great scientific work by which a bulwark against cholera was drawn almost literally across Europe, and was defended as if with the mounted soldiery of science and humanity. True enough, cholera managed to plant itself in Italy in 1886, and in Hamburg in 1892, and the plague was scattered into several German towns. But it came to Hamburg by water, not by land. It did there during the summer a dreadful work, but the battle was the Waterloo of the enemy. Not again while the present order continues will it be possible for the dreaded epidemic to get the mastery of a great German city.
It was to be anticipated that Dr. Koch's discovery of the tubercle bacillus would lead him on to the discovery of a cure for tuberculosis. Very naturally his thought on this subject was borne in the direction of inoculation. That method had been used by Pasteur and by himself in the case of other infectious diseases. Why should it not be employed in consumption? If the "domestication," so-called, of the virus of splenic fever and the use of the modified poison as an antiseptic preventive of the disease was successful, as it had been proved to be, why should this not be done with the attenuated virus of consumption?
The last five years of the ninth decade were spent by Dr. Koch in experimentation on this subject. He found that the tubercular poison might be treated in the same manner as the poison of other infectious diseases. He experimented with methods for domesticating the bacillus of consumption, and reached successful results. On the fourteenth of November, 1890, he published in a German medical magazine at Berlin a communication on a possible remedy for tuberculosis. He had prepared a sort of lymph suitable for hypodermic injection, and with this had experimented on a form of external tuberculosis called lupus. This disease is a consumption of the skin and adjacent tissues. It is a malady almost as dreadful as consumption of the lungs, but is by no means frequent in its occurrence. It is found only at rare intervals by the medical practitioner.
Dr. Koch had demonstrated that lupus is a true tuberculosis—that the germ which produces it is the same bacillus which produces consumption of the lungs. He accordingly directed his effort to cases of lupus, treating the patients with hypodermic injections which he had prepared from the modified form of the tubercular poison. He was successful in the treatment, and was able to announce, to the joy of the world, that he had discovered a cure for lupus; and the announcement went so far as to express a belief in the salutary character of the remedy in the treatment of consumption of the lungs.
Dr. Koch, however, with the usual caution of the true men of science, did not announce his tuberculin, or lymph, as a cure for pulmonary consumption. He did not even declare that it was positively a remedy for the other forms of tuberculosis, but did announce his cure of cases of lupus by the agent which he had prepared. The world, after its manner, leaped at conclusions, and the newspapers of two continents, in their usual office of disseminating ignorance, trumpeted Koch's discovery as the end of tubercular consumption.
In January of 1891, Dr. Koch published to the world the composition of his remedy. It consists of a glycerine extract prepared by the cultivation of tubercle bacilli. The lymph contains, as it were, the poisonous matter resulting from the life and activity of the tubercle bacterium. The fluid is used by hypodermic injection, and when so administered produces both a general and local reaction. The system is powerfully affected. A sense of weariness comes on. The breathing is labored. Nausea ensues; and a fever supervenes which lasts for twelve or fifteen hours. It is now known that the action of the remedy is not directly against the tubercle bacilli, but rather against the affected tissue in which they exist. This tissue is destroyed and thrown off by the agency of the lymph; being destroyed, it is eliminated and cast out, carrying with it the bacteria on which the disease depends.
The results which have followed the administration of Koch's lymph for consumption of the lungs have not met the expectation of the public; but something has been accomplished. Ignorant enthusiasm has meanwhile subsided, and scientific men in both Europe and America are pressing the inquiry in a way which promises in due time the happiest results.