At the close of one year after the attempted surprise of Plataea by the Thebans, the belligerent parties in Greece remained in an unaltered position as to relative strength. Nothing decisive had been accomplished on either side, either by the invasion of Attica or by the flying descents round the coast of Peloponnesus. In spite of mutual damage inflicted—doubtless in the greatest measure upon Attica—no progress was yet made toward the fulfilment of those objects which had induced the Peloponnesians to go to war. Especially the most pressing among all their wishes—the relief of Potidaea—was in no way advanced; for the Athenians had not found it necessary to relax the blockade of that city, The result of the first year's operations had thus been to disappoint the hopes of the Corinthians and the other ardent instigators of war, while it justified the anticipations both of Pericles and of Archidamus.

A second devastation of Attica was resolved upon for the commencement of spring; and measures were taken for carrying it all over that territory, since the settled policy of Athens, not to hazard a battle with the invaders, was now ascertained. About the end of March or beginning of April the entire Peloponnesian force—two-thirds from each confederate city as before—was assembled under the command of Archidamus and marched into Attica. This time they carried the work of systematic destruction not merely over the Thriasian plain and the plain immediately near to Athens, as before; but also to the more southerly portions of Attica, down even as far as the mines of Laurium. They traversed and ravaged both the eastern and the western coast, remaining not less than forty days in the country. They found the territory deserted as before, all the population having retired within the walls.

In regard to this second invasion, Pericles recommended the same defensive policy as he had applied to the first; and apparently the citizens had now come to acquiesce in it, if not willingly, at least with a full conviction of its necessity. But a new visitation had now occurred, diverting their attention from the invader, though enormously aggravating their sufferings. A few days after Archidamus entered Attica, a pestilence or epidemic sickness broke out unexpectedly at Athens.

It appears that this terrific disorder had been raging for some time throughout the regions round the Mediterranean; having begun, as was believed, in Ethiopia—thence passing into Egypt and Libya, and overrunning a considerable portion of Asia under the Persian government. About sixteen years before, there had been a similar calamity in Rome and in various parts of Italy. Recently it had been felt in Lemnos and some other islands of the Aegean, yet seemingly not with such intensity as to excite much notice generally in the Grecian world: at length it passed to Athens, and first showed itself in the Piraeus. The progress of the disease was as rapid and destructive as its appearance had been sudden; while the extraordinary accumulation of people within the city and long walls, in consequence of the presence of the invaders in the country, was but too favorable to every form of contagion. Families crowded together in close cabins and places of temporary shelter—throughout a city constructed, like most of those in Greece, with little regard to the conditions of salubrity and in a state of mental chagrin from the forced abandonment and sacrifice of their properties in the country, transmitted the disorder with fatal facility from one to the other. Beginning as it did about the middle of April, the increasing heat of summer further aided the disorder, the symptoms of which, alike violent and sudden, made themselves the more remarked because the year was particularly exempt from maladies of every other description.

Of this plague—or, more properly, eruptive typhoid fever, distinct from, yet analogous to, the smallpox—a description no less clear than impressive has been left by the historian Thucydides, himself not only a spectator but a sufferer. It is not one of the least of his merits, that his notice of the symptoms, given at so early a stage of medical science and observation, is such as to instruct the medical reader of the present age, and to enable the malady to be understood and identified. The observations with which that notice is ushered in deserve particular attention. "In respect to this distemper (he says), let every man, physician or not, say what he thinks respecting the source from whence it may probably have arisen, and respecting the causes which he deems sufficiently powerful to have produced so great a revolution. But I, having myself had the distemper, and having seen others suffering under it, will state what it actually was, and will indicate in addition such other matters as will furnish any man, who lays them to heart, with knowledge and the means of calculation beforehand, in case the same misfortune should ever occur again."

To record past facts, as a basis for rational prevision in regard to the future—the same sentiment which Thucydides mentions in his preface, as having animated him to the composition of his history—was at that time a duty so little understood that we have reason to admire not less the manner in which he performs it in practice than the distinctness with which he conceives it in theory. We infer from his language that speculation in his day was active respecting the causes of this plague, according to the vague and fanciful physics, and scanty stock of ascertained facts, which was all that could then be consulted. By resisting the itch of theorizing from one of those loose hypotheses which then appeared plausibly to explain everything, he probably renounced the point of view from which most credit and interest would be derivable at the time. But his simple and precise summary of observed facts carries with it an imperishable value, and even affords grounds for imagining that he was no stranger to the habits and training of his contemporary Hippocrates, and the other Asclepiads of Cos.

It is hardly within the province of a historian of Greece to repeat after Thucydides the painful enumeration of symptoms, violent in the extreme and pervading every portion of the bodily system, which marked this fearful disorder. Beginning in Piraeus, it quickly passed into the city, and both the one and the other was speedily filled with sickness and suffering, the like of which had never before been known. The seizures were sudden, and a large proportion of the sufferers perished after deplorable agonies on the seventh or on the ninth day. Others, whose strength of constitution carried them over this period, found themselves the victims of exhausting and incurable diarrhoea afterward; with others again, after traversing both these stages, the distemper fixed itself in some particular member, the eyes, the genitals, the hands, or the feet, which were rendered permanently useless, or in some cases amputated, even where the patient himself recovered.

There were also some whose recovery was attended with a total loss of memory, so that they no more knew themselves or recognized their friends. No treatment or remedy appearing, except in accidental cases, to produce any beneficial effect, the physicians or surgeons whose aid was invoked became completely at fault. While trying their accustomed means without avail, they soon ended by catching the malady themselves and perishing. The charms and incantations, to which the unhappy patient resorted, were not likely to be more efficacious. While some asserted that the Peloponnesians had poisoned the cisterns of water, others referred the visitation to the wrath of the gods, and especially to Apollo, known by hearers of the Iliad as author of pestilence in the Greek host before Troy. It was remembered that this Delphian god had promised the Lacedaemonians, in reply to their application immediately before the war, that he would assist them whether invoked or uninvoked; and the disorder now raging was ascribed to the intervention of their irresistible ally; while the elderly men further called to mind an oracular verse sung in the time of their youth: "The Dorian war will come, and pestilence along with it." Under the distress which suggested, and was reciprocally aggravated by these gloomy ideas, prophets were consulted, and supplications with solemn procession were held at the temples, to appease the divine wrath.

When it was found that neither the priest nor the physician could retard the spread or mitigate the intensity of the disorder, the Athenians abandoned themselves to despair, and the space within the walls became a scene of desolating misery. Every man attacked with the malady at once lost his courage—a state of depression itself among the worst features of the case, which made him lie down and die, without any attempt to seek for preservatives. And although at first friends and relatives lent their aid to tend the sick with the usual family sympathies, yet so terrible was the number of these attendants who perished, "like sheep," from such contact, that at length no man would thus expose himself; while the most generous spirits, who persisted longest in the discharge of their duty, were carried off in the greatest numbers. The patient was thus left to die alone and unheeded. Sometimes all the inmates of a house were swept away one after the other, no man being willing to go near it: desertion on the one hand, attendance on the other, both tended to aggravate the calamity. There remained only those who, having had the disorder and recovered, were willing to tend the sufferers.

These men formed the single exception to the all-pervading misery of the time—for the disorder seldom attacked anyone twice, and when it did the second attack was never fatal. Elate with their own escape, they deemed themselves out of the reach of all disease, and were full of compassionate kindness for others whose sufferings were just beginning. It was from them too that the principal attention to the bodies of deceased victims proceeded: for such was the state of dismay and sorrow that even the nearest relatives neglected the sepulchral duties, sacred beyond all others in the eyes of a Greek. Nor is there any circumstance which conveys to us so vivid an idea of the prevalent agony and despair as when we read, in the words of an eyewitness, that the deaths took place among this close-packed crowd without the smallest decencies of attention—that the dead and the dying lay piled one upon another not merely in the public roads, but even in the temples, in spite of the understood defilement of the sacred building—that half-dead sufferers were seen lying round all the springs, from insupportable thirst—that the numerous corpses thus unburied and exposed were in such a condition that the dogs which meddled with them died in consequence, while no vultures or other birds of the like habits ever came near.