It is probable that the matter was already mooted in 1525, a year which saw new proof of Anne's influence in the elevation of Sir Thomas Boleyn to the baronage as Lord Rochford. It is certain that it was the object of secret negotiation with the Pope in 1526. No sovereign stood higher in the favor of Rome than Henry, whose alliance had ever been ready in its distress and who was even now prompt with aid in money. But Clement's consent to his wish meant a break with the Emperor, Catharine's nephew; and the exhaustion of France, the weakness of the league in which the lesser Italian states strove to maintain their independence against Charles after the battle of Pavia, left the Pope at the Emperor's mercy. While the English envoy was mooting the question of divorce in 1526 the surprise of Rome by an imperial force brought home to Clement his utter helplessness.

It is hard to discover what part Wolsey had as yet taken in the matter, or whether as in other cases Henry had till now been acting alone, though the Cardinal himself tells us that on Catharine's first discovery of the intrigue she attributed the proposal of divorce to "my procurement and setting forth." But from this point his intervention is clear. As legate he took cognizance of all matrimonial causes, and in May, 1527, a collusive action was brought in his court against Henry for cohabiting with his brother's wife. The King appeared by proctor; but the suit was suddenly dropped. Secret as were the proceedings, they had now reached Catharine's ear; and as she refused to admit the facts on which Henry rested his case her appeal would have carried the matter to the tribunal of the Pope, and Clement's decision could hardly be a favorable one.

The Pope was now in fact a prisoner in the Emperor's hands. At the very moment of the suit Rome was stormed and sacked by the army of the Duke of Bourbon. "If the Pope's holiness fortune either to be slain or taken," Wolsey wrote to the King when the news of this event reached England, "it shall not a little hinder your grace's affairs." But it was needful for the Cardinal to find some expedient to carry out the King's will, for the group around Anne were using her skilfully for their purposes. A great party had now gathered to her support. Her uncle, the Duke of Norfolk, an able and ambitious man, counted on her rise to set him at the head of the council board; the brilliant group of young courtiers to which her brother belonged saw in her success their own elevation; and the Duke of Suffolk with the bulk of the nobles hoped through her means to bring about the ruin of the statesman before whom they trembled.

What most served their plans was the growth of Henry's passion. "If it please you," the King wrote at this time to Anne Boleyn, "to do the office of a true, loyal mistress, and give yourself body and heart to me, who have been and mean to be your loyal servant, I promise you not only the name but that I shall make you my sole mistress, remove all others from my affection, and serve you only." What stirred Henry's wrath most was Catharine's "stiff and obstinate" refusal to bow to his will. Wolsey's advice that "your Grace should handle her both gently and doulcely" only goaded Henry's impatience. He lent an ear to the rivals who charged his minister with slackness in the cause, and danger drove the Cardinal to a bolder and yet more unscrupulous device.

The entire subjection of Italy to the Emperor was drawing closer the French alliance, and a new treaty had been concluded in April. But this had hardly been signed when the sack of Rome and the danger of the Pope called for bolder measures. Wolsey was despatched on a solemn embassy to Francis to promise an English subsidy on the despatch of a French army across the Alps. But he aimed at turning the Pope's situation to the profit of the divorce. Clement was virtually a prisoner in the castle of St. Angelo; and as it was impossible for him to fulfil freely the function of a Pope, Wolsey proposed, in conjunction with Francis, to call a meeting of the college of cardinals at Avignon which should exercise the papal powers till Clement's liberation. As Wolsey was to preside over this assembly, it would be easy to win from it a favorable answer to Henry's request.

But Clement had no mind to surrender his power, and secret orders from the Pope prevented the Italian cardinals from attending such an assembly. Nor was Wolsey more fortunate in another plan for bringing about the same end by inducing Clement to delegate to him his full powers westward of the Alps. Henry's trust in him was fast waning before these failures and the steady pressure of his rivals at court, and the coldness of the King on his return in September was an omen of his minister's fall. Henry was in fact resolved to take his own course; and while Wolsey sought from the Pope a commission enabling him to try the case in his legatine court and pronounce the marriage null and void by sentence of law, Henry had determined at the suggestion of the Boleyns and apparently of Thomas Cranmer, a Cambridge scholar who was serving as their chaplain, to seek, without Wolsey's knowledge, from Clement either his approval of a divorce or, if a divorce could not be obtained, a dispensation to remarry without any divorce at all.

For some months his envoys could find no admission to the Pope; and though in December Clement succeeded in escaping to Orvieto and drew some courage from the entry of the French army into Italy, his temper was still too timid to venture on any decided course. He refused the dispensation altogether. Wolsey's proposal for leaving the matter to a legatine court found better favor; but when the commission reached England it was found to be "of no effect or authority." What Henry wanted was not merely a divorce but the express sanction of the Pope to his divorce, and this Clement steadily evaded. A fresh embassy, with Wolsey's favorite and secretary, Stephen Gardiner, at its head, reached Orvieto in March, 1528, to find, in spite of Gardiner's threats, hardly better success; but Clement at last consented to a legatine commission for the trial of the case in England. In this commission Cardinal Campeggio, who was looked upon as a partisan of the English King, was joined with Wolsey.

Great as the concession seemed, this gleam of success failed to hide from the minister the dangers which gathered round him. The great nobles whom he had practically shut out from the King's counsels were longing for his fall. The Boleyns and the young courtiers looked on him as cool in Anne's cause. He was hated alike by men of the old doctrine and men of the new. The clergy had never forgotten his extortions, the monks saw him suppressing small monasteries. The foundation of Cardinal College failed to reconcile to him the scholars of the New Learning; their poet, Skelton, was among his bitterest assailants.

The Protestants, goaded by the persecution of this very year, hated him with a deadly hatred. His French alliances, his declaration of war with the Emperor, hindered the trade with Flanders and secured the hostility of the merchant class. The country at large, galled with murrain and famine and panic-struck by an outbreak of the sweating sickness which carried off two thousand in London alone, laid all its suffering at the door of the Cardinal. And now that Henry's mood itself became uncertain Wolsey knew his hour was come. Were the marriage once made, he told the French ambassador, and a male heir born to the realm, he would withdraw from state affairs and serve God for the rest of his life. But the divorce had still to be brought about ere marriage could be made or heir be born. Henry indeed had seized on the grant of a commission as if the matter were at an end. Anne Boleyn was installed in the royal palace and honored with the state of a wife. The new legate, Campeggio, held the bishopric of Salisbury, and had been asked for as judge from the belief that he would favor the King's cause. But he bore secret instructions from the Pope to bring about if possible a reconciliation between Henry and the Queen, and in no case to pronounce sentence without reference to Rome. The slowness of his journey presaged ill; he did not reach England till the end of September, and a month was wasted in vain efforts to bring Henry to a reconciliation or Catharine to retirement into a monastery.

A new difficulty disclosed itself in the supposed existence of a brief issued by Pope Julius and now in the possession of the Emperor, which overruled all the objections to the earlier dispensation on which Henry relied. The hearing of the cause was delayed through the winter, while new embassies strove to induce Clement to declare this brief also invalid. Not only was such a demand glaringly unjust, but the progress of the imperial arms brought vividly home to the Pope its injustice. The danger which he feared was not merely a danger to his temporal domain in Italy—it was a danger to the papacy itself. It was in vain that new embassies threatened Clement with the loss of his spiritual power over England. To break with the Emperor was to risk the loss of his spiritual power over a far larger world.