The modesty of Jenner was evidenced in his original intention of submitting his observations on the cowpox in a paper addressed to the Royal Society. Doctor Baron tells us that "when the subject was laid before the president (the late Sir Joseph Banks), Jenner was given to understand that he should be cautious and prudent; that he had already gained some credit by his communications to the Royal Society and ought not to risk his reputation by presenting to the learned body anything which appeared so much at variance with established knowledge, and withal so incredible." It came forth most unostentatiously, about the end of June, 1798, dedicated to his friend Doctor Parry of Bath. Doctor Jenner visited London in the month of April of that year, and remained until July 14th. His object in this visit was to demonstrate the disease to his professional friends, but such was the distrust, or apathy, felt on the occasion, that Jenner returned to the country, without having been able to prevail on a single individual to submit to the inoculation of the virus.
The virus Jenner brought to London was consigned to the care of the late Mr. Cline, of St. Thomas's Hospital. This celebrated surgeon inserted some of it, by two punctures, into the hip of a young patient with a disease of that part of the body. This calescent mode of proceeding was adopted with the idea of exciting a counter-irritation in the diseased part. The intention was to convert the vesicles into an issue, after the progress of the cowpox had been observed. This idea was, however, abandoned. Smallpox matter was afterward inserted into this child in three places. It produced a slight inflammation on the third day, and then subsided. The child was effectually protected against the disease. Mr. Cline now became very sanguine as to the result and inoculated three other children with lymph taken from the vesicles of the child, but no evil effect ensued. The subject began to excite the attention of the profession, and all were eager to put the matter to the test of experiment. Mr. Cline urged Doctor Jenner to settle in London. He promised him ten thousand pounds a year as the result of his practice. What was his reply?
"Shall I, who even in the morning of my days, sought the lowly and sequestered paths of life, the valley, and not the mountain; shall I, now my evening is fast approaching, hold myself up as an object for fortune and for fame? Admitting it as a certainty that I obtain both, what stock should I add to my little fund of happiness? My fortune, with what flows in from my profession, is sufficient to gratify my wishes; indeed, so limited is my ambition, and that of my nearest connections, that even were I precluded from future practice I should be enabled to satisfy all my wants. As for fame, what is it? A gilded butt, forever pierced with the arrows of malignancy."
That a discovery of such importance to mankind, once divulged, should bring forth many claimants, and that its author should be subjected to virulent attacks, is easy to be conceived. Jenner, however, never thought it necessary to reply to unfounded and harsh aspersions, satisfied in the strength of his own case, and feeling the justice and truth of his own claims and position. The practice being now established, it is unnecessary even to refer to the names of the opponents of vaccination. Many mistakes, and some of a serious nature, occurred to interrupt the progress of the discovery; these had been for the most part foreseen by Jenner, and were satisfactorily explained. In a letter to a friend, Jenner says, "I will just drop a hint. The vaccine disease, in my opinion, is not a preventive of the smallpox, but the smallpox itself; that is to say, the horrible form under which the disease appears in its contagious state is, as I conceive, a malignant variety." Again: "What I have said on this vaccine subject is true. If properly conducted, it secures the constitution as much as variolous inoculation possibly can. It is the smallpox in a purer form than that which has been current among us for twelve centuries past." And, in a letter to Mr. Pruen, "I have ever considered the variola and the vaccine radically and essentially the same. As the inoculation of the former has been known to fail, in instances so numerous, it would be very extraordinary if the latter should always be exempt from failure. It would tend to invalidate my early doctrine on this point."
It is not necessary here to dwell upon the fatality of the smallpox when taken in the natural way, or to show that the mortality has been increased by the practice of inoculation, which creates an atmosphere for the constant propagation of the disease; these have been satisfactorily demonstrated in evidence before the House of Commons, and anyone may readily obtain this information. It is, however, interesting to record the names of those who, abandoning all prejudice and solicitous to promote a general good, submitted to the practice at its earliest period. Mr. Henry Hicks was the first to submit his own children to the vaccination. Lady Frances Morton (Lady Ducie) was the first personage of rank who had her child, and her only child, vaccinated. The Countess of Berkeley was instrumental in forwarding it; and the children of King William IV were vaccinated by Mr. Knight.
Jenner's discovery entailed upon him a most extensive correspondence, and obliged him frequently to travel in London. His professional engagements were not only interrupted, but almost annihilated, and his private fortune encroached upon by such circumstances. His friends urged an application to Parliament. A petition to Parliament was presented on March 17, 1802, and Mr. Addington—later, Lord Sidmouth—informed the House that he had taken the King's pleasure on the contents of the petition and that His Majesty recommended it strongly to the consideration of Parliament. A committee was appointed, of which Admiral Berkeley was the chairman. A great mass of evidence was brought forward, and many professional and other persons examined. The Duke of Clarence gave his testimony, and manifested strongly his conviction of the prophylactic powers of the vaccine disease. Much opposition was offered to the claims of Jenner. He felt this deeply, and in a letter to his friend Mr. Hicks, dated April 28, 1802, he writes: "I sometimes wish this business had never been brought forward. It makes me feel indignant to reflect that one who has, through a most painful and laborious investigation, brought to light a subject that will add to the happiness of every human being in the world, should appear among his countrymen as a supplicant for the means of obtaining a few comforts for himself and family."
The committee reported, and the House voted ten thousand pounds to Doctor Jenner. An amendment, proposing twenty thousand pounds, was lost by a majority of three! Sir Gilbert Blane, Doctor Lettsom, and others, feeling the utter inadequacy of this reward to the merits of the case, proposed to raise a fund by public subscription; but it was not carried into effect.
The Royal Jennerian Society was established in 1803, and had the King for the patron, the Queen for the patroness, and various members of the royal family and nobility for its supporters. The design of the institution was to vaccinate the poor gratuitously, and supply virus to all parts of the world. It effected great good, and reduced the number of deaths by smallpox in a very remarkable degree. But dissensions sprang up, chiefly through the conduct of the resident inoculator recommending practices contrary to the printed regulations of the society, and it was virtually dissolved in 1806.
Lord Henry Petty—later, Marquis of Lansdowne—was the chancellor of the exchequer in 1806, and on July 2d brought the subject of vaccination again before the House of Parliament. Upon this, the College of Physicians was directed to make inquiry into its state and condition, and a report was made on April 19, 1807. The report was highly satisfactory as to the advantages of the practice. On July 29th the Right Honorable Spencer Perceval,[47] being then chancellor of exchequer, called the attention of the House to it, and moved an additional grant of ten thousand pounds, when an amendment to double the sum was proposed by Mr. Edward Morris, M.P. for Newport, in Cornwall, and carried by a majority of thirteen. In 1808 the "National Vaccine Establishment" was formed, where the practice of vaccination and the supply of lymph has ever since been continued.
Foreign academies and societies enrolled Doctor Jenner in the lists of their associates, and the medical societies of his own country were not less anxious to adorn their roster with his name. In 1808 he was elected a corresponding member of the National Institute, and in 1811 was chosen an associate, in place of Doctor Mackelyne, deceased. The Empress Dowager of Russia sent him a diamond ring, accompanied by a letter in testimony of her admiration of vaccination. She had the first child vaccinated in Russia named "Vaccinoff," and fixed a pension upon it for life. The Medical Society of London presented him with a gold medal; the Physical Society of Guy's Hospital instituted a new order of members, under the title of "Honorary Associates," and named Jenner for the first; the nobility and gentry of Gloucestershire presented him with a handsome gold cup; and various other marks of consideration were bestowed upon him as testimonies to the benefits he had conferred upon mankind. He was chosen mayor of his native town; received the freedom of the corporation of Dublin; the freedom of the city of Edinburgh; and elected an honorary fellow of the Royal College of Physicians of that city. In 1813 the University of Oxford granted him a degree of Doctor in Physic, by a decree of the convocation. The diploma was presented him by Sir C. Pegge and Doctor Kidd, the professors of anatomy and chemistry. On this occasion—and a similar honor had not been conferred by the university on any man for nearly seventy years before—Doctor Jenner observed, "It is remarkable that I should have been the only one of a long line of ancestors and relations who was not educated at Oxford. They were determined to turn me into the meadows, instead of allowing me to flourish in the groves of Academus. It is better, perhaps, as it is, especially as I have arrived at your highest honors without complying with your ordinary rules of discipline." The conduct of the London College of Physicians, it is painful to remark, was not characterized by such liberality. The majority of the fellows refused to admit him without the usual examination. Many of the fellows were anxious upon the subject, but their wishes did not prevail.