181 Pharnaces attacks Eumenes of Pergamus and Ariarathes of Cappadocia.
179 Pharnaces purchases peace, ceding all his possessions in Galatia and Paphlagonia, excepting Sinope.
156 Mithridates (V) Euergetes succeeds his father.
154 He assists Attalus II of Pergamus against Prusias II of Bithynia.
149-146 During the Third Punic War, Mithridates makes alliance with Rome, supplying ships and men.
131-129 Mithridates aids Rome against Aristonicus, for which he receives Phrygia.
120 Assassination of Mithridates at Sinope. Succeeded by his son Mithridates (VI) Eupator, the Great. The Romans take Phrygia from him. In the early years of his reign he subdues many warlike tribes, and incorporates the kingdom of Bosporus in his dominions. He attempts to gain control of Cappadocia, and drives Nicomedes III of Bithynia from his throne.
88 War breaks out with Rome on account of the Bithynian succession. Mithridates overruns Asia Minor, massacring Roman citizens.
84 Mithridates makes peace with Sulla.
83 Murena invades Pontus without reason and is defeated the following year.